[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-362091-105":59,"doc-detail-362091-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","impact-of-the-ecm-on-the-mechanical-memory-of-cancer-cells-review","Impact of the ECM on the Mechanical Memory of Cancer Cells - Review","","Besides genomic and proteomic analyses of bulk and individual cancer cells, cancer research increasingly relies on mechanical analysis. During oncogenic evolution, mechanical inputs can be stored as epigenetic-like mechanical memory, enabling versatile encoding of malignant traits and faster responses than mutation-only clonal selection. Mechanical memory is proposed to store complex features such as metastatic phenotypes, therapy resistance, and cancer–environment interactions across multiple biological levels. This review focuses on how the ECM shapes mechanical memory during metastatic spread and how shared mechanisms can guide dynamic assessment of tumor malignant potency.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/impact-of-the-ecm-on-the-mechanical-memory-of-cancer-cells-review/362091/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/impact-of-the-ecm-on-the-mechanical-memory-of-cancer-cells-review/362091.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main role of mechanical memory in cancer metastasis according to the review?","Question",{"text":112,"@type":113},"Mechanical memory in cell–matrix interactions is proposed to significantly influence events across the metastatic cascade.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How can knowledge of mechanical memory improve cancer therapy?",{"text":117,"@type":113},"Improved tumor therapy may be achieved by combining inhibitors targeting altered tumor-matrix mechanics (e.g., increased stiffness) with established drugs that better reach the site of action.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is dynamic assessment of mechanical memory important for predicting tumor malignant potency?",{"text":121,"@type":113},"Shared mechanical-memory mechanisms across cancer types suggest a universal phenomenon, but predicting individual potency requires assessing these mechanisms dynamically rather than relying only on static information.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},362091,1791123302,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Review  \nImpact of the ECM on the Mechanical Memory of Cancer Cells Claudia Tanja Mierke   \nAcademic Editor: Alexander  \nE. Kalyuzhny  \nReceived: 9 October 2025  \nRevised: 24 October 2025  \nAccepted: 28 October 2025  \nPublished: 30 October 2025  \nCitation: Mierke, C.T. Impact of the ECM on the Mechanical Memory of Cancer Cells. Cells 2025, 14, 1707 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cells14211707  \nCopyright: © 2025 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \nFaculty of Physics and Earth System Sciences, Peter Debye Institute of Soft Matter Physics, Biological Physics Division, Leipzig University, 04103 Leipzig, Germany; [claudia.mierke@uni-leipzig.de](claudia.mierke@uni-leipzig.de)  \nHighlights  \nWhat are the main findings?  \n• Mechanical memory in the cell-matrix interactions appears to play a significant role at various levels in the metastatic cascade in cancer.  \n• The effect of mechanical memory influences the effectiveness of therapeutic approaches in cancer.  \nWhat is the implication of the main finding?  \n• Knowledge of mechanical memory can lead to improved tumor therapy by combining inhibitors of the altered mechanical properties of the tumor matrix, such as increased stiffness, with established drugs that can better reach the site of action.  \n• Common mechanical memory mechanisms of different types of cancer point to a universal phenomenon and as such need to be assessed in a dynamic manner to precisely predict the individual malignant potency of tumors.  \nAbstract  \nBesides genomic and proteomic analyses of bulk and individual cancer cells, cancer research focuses on the mechanical analysis of cancers, such as cancer cells. Throughout the oncogenic evolution of cancer, mechanical inputs are stored as epigenetic memory, which ensures versatile coding of malignant characteristics and a quicker response to external environmental influences in comparison to solely mutation-based clonal evolutionary mechanisms. Cancer’s mechanical memory is a proposed mechanism for how complex details such as metastatic phenotypes, treatment resistance, and the interaction of cancers with their environment could be stored at multiple levels. The mechanism appears to be similar to the formation of memories in the brain and immune system like epigenetic alterations in individual cells and scattered state changes in groups of cells. Carcinogenesis could therefore be the outcome of physiological multistage feedback mechanisms triggered by specific heritable oncogenic alterations, resulting in a tumor-specific disruption of the integration of the target site/tissue into the overall organism. This review highlights and discusses the impact of the ECM on cancer cells’ mechanical memory during their metastatic spread. Additionally, it demonstrates how the emergence of a mechanical memory of cancer can give rise to new degrees of individuality within the host organism, anda connection to the cancer entity is established by discussing a connection to the metastasis cascade. The aim is to identify common mechanical memory mechanisms of different types of cancer. Finally, it is emphasized that efforts to identify the malignant potency of tumors should go way beyond sequencing approaches and include a functional diagnosis of cancer physiology and a dynamic mechanical assessment of cancer cells.  \nKeywords: environmental mechanical cues; mechanical memory; viscoelasticity; stiffness; epigenetics; mechanobiology; deformability; traction forces  \n1. Introduction to Mechanical Memory  \nThe physical migration to and invasion of cancer cells of targeted tissue sides during cancer metastasis represents a clear sign of malignant cancer p","cbCaivvZ5jrFwFGf","https://ap.wps.com/l/cbCaivvZ5jrFwFGf","pdf",9743380,54,"English","# Highlights\n## What are the main findings?\n## What is the implication of the main finding?\n# Abstract\n# 1. Introduction to Mechanical Memory\n# 2. The Amount of Mechanical Memory Is Impacted by the Intensity and Length of the Mechanical Stress","[{\"question\":\"What is the main role of mechanical memory in cancer metastasis according to the review?\",\"answer\":\"Mechanical memory in cell–matrix interactions is proposed to significantly influence events across the metastatic cascade.\"},{\"question\":\"How can knowledge of mechanical memory improve cancer therapy?\",\"answer\":\"Improved tumor therapy may be achieved by combining inhibitors targeting altered tumor-matrix mechanics (e.g., increased stiffness) with established drugs that better reach the site of action.\"},{\"question\":\"Why is dynamic assessment of mechanical memory important for predicting tumor malignant potency?\",\"answer\":\"Shared mechanical-memory mechanisms across cancer types suggest a universal phenomenon, but predicting individual potency requires assessing these mechanisms dynamically rather than relying only on static information.\"}]","Impact of the ECM on the Mechanical Memory of Cancer Cells - Review | PDF",1790146445,136]