[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-381112-105":59,"doc-detail-381112-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","impact-of-the-cancer-cell-secretome-in-driving-breast-cancer-progression","Impact of the Cancer Cell Secretome in Driving Breast Cancer Progression","","Breast cancer is a complex, heterogeneous malignancy driven by accumulated genetic and epigenetic alterations in breast epithelial cells. Despite advances in detection and therapy, it remains the most prevalent cancer in women worldwide. Extracellular cues surrounding tumor cells, shaped by a protein network termed the secretome, are closely linked to disease onset, progression, metastasis, and immune evasion. Secretome-driven pathway modulation and tumor microenvironment remodeling also contribute to pre-metastatic niche formation and therapy resistance.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/impact-of-the-cancer-cell-secretome-in-driving-breast-cancer-progression/381112/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/impact-of-the-cancer-cell-secretome-in-driving-breast-cancer-progression/381112.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the role of the cancer cell secretome in breast cancer progression?","Question",{"text":113,"@type":114},"The secretome promotes tumorigenesis by modulating growth-associated signaling, reshaping the tumor microenvironment, supporting pre-metastatic niche formation, and facilitating immunosurveillance evasion.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does the secretome contribute to metastasis in breast cancer?",{"text":118,"@type":114},"Secretome components influence metastatic properties by interacting with elements of the tumor microenvironment and promoting conditions favorable for spread.",{"name":120,"@type":111,"acceptedAnswer":121},"Why is the secretome considered an attractive target for breast cancer therapy?",{"text":122,"@type":114},"Targeting secretome constituents may address therapy resistance and can reveal new molecular pathways and specific targets to enable more innovative treatments.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},381112,1790380038,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","cancers   \nReview  \nImpact of the Cancer Cell Secretome in Driving Breast Cancer Progression  \nSyazalina Zahari , Saiful Effendi Syafruddin  and M. Aiman Mohtar *  \nCitation: Zahari, S.; Syafruddin, S.E.; Mohtar, M.A. Impact of the Cancer Cell Secretome in Driving Breast Cancer Progression. Cancers 2023, 15, 2653. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)cancers15092653  \nAcademic Editors: Enrico Cassano and Filippo Pesapane  \nReceived: 14 April 2023  \nRevised: 4 May 2023  \nAccepted: 4 May 2023  \nPublished: 8 May 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nUKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia,  \nKuala Lumpur 56000, Malaysia; [p111431@siswa.ukm.edu.my](p111431@siswa.ukm.edu.my) (S.Z.); [effendisy@ppukm.ukm.edu.my](effendisy@ppukm.ukm.edu.my) (S.E.S.)  \n* [Correspondence: m.aimanmohtar@ppukm.ukm.edu.my](Correspondence: m.aimanmohtar@ppukm.ukm.edu.my)  \nSimple Summary: Breast cancer is a complex disease that remains a significant public health challenge. The breast cancer cells secrete various substances collectively known as the secretome, which include proteins, lipids, and nucleic acids that contribute to the growth and spread of breast cancer. The secretome plays a crucial role in the development and progression of breast cancer by modifying signaling pathways and creating an environment supporting cancer growth while evading the immune system. Additionally, the secretome is responsible for the development of resistance to cancer drugs, making it a significant challenge for effective treatment. Therefore, understanding the role of the secretome in breast cancer is essential for developing innovative therapies. This review provides insights into the impact of the secretome on breast cancer progression and its interactions with the tumor microenvironment, and explores potential therapeutic opportunities targeting the secretome components. By identifying specific molecules and signaling pathways involved in the secretome, new targets for therapeutic intervention can be identified, which can ultimately improve outcomes for breast cancer patients.  \nAbstract: Breast cancer is a complex and heterogeneous disease resulting from the accumulation of genetic and epigenetic alterations in breast epithelial cells. Despite remarkable progress in diagnosis and treatment, breast cancer continues to be the most prevalent cancer affecting women worldwide. Recent research has uncovered a compelling link between breast cancer onset and the extracellular environment enveloping tumor cells. The complex network of proteins secreted by cancer cells and other cellular components within the tumor microenvironment has emerged as a critical player in driving the disease's metastatic properties. Specifically, the proteins released by the tumor cells termed the secretome, can significantly influence the progression and metastasis of breast cancer. The breast cancer cell secretome promotes tumorigenesis through its ability to modulate growthassociated signaling pathways, reshaping the tumor microenvironment, supporting pre-metastatic niche formation, and facilitating immunosurveillance evasion. Additionally, the secretome has been shown to play a crucial role in drug resistance development, making it an attractive target for cancer therapy. Understanding the intricate role of the cancer cell secretome in breast cancer progression will provide new insights into the underlying mechanisms of this disease and aid in the development of more innovative therapeutic interventions. Hence, this review provides a nuanced analysis of the impact of the cancer cell secretome on ","cbCaim3oBPNC7siX","https://ap.wps.com/l/cbCaim3oBPNC7siX","pdf",1291877,17,"English","# Introduction\n## Breast cancer heterogeneity and clinical burden\n## Secretome and tumor microenvironment interactions\n# Therapeutic implications","[{\"question\":\"What is the role of the cancer cell secretome in breast cancer progression?\",\"answer\":\"The secretome promotes tumorigenesis by modulating growth-associated signaling, reshaping the tumor microenvironment, supporting pre-metastatic niche formation, and facilitating immunosurveillance evasion.\"},{\"question\":\"How does the secretome contribute to metastasis in breast cancer?\",\"answer\":\"Secretome components influence metastatic properties by interacting with elements of the tumor microenvironment and promoting conditions favorable for spread.\"},{\"question\":\"Why is the secretome considered an attractive target for breast cancer therapy?\",\"answer\":\"Targeting secretome constituents may address therapy resistance and can reveal new molecular pathways and specific targets to enable more innovative treatments.\"}]","Impact of the Cancer Cell Secretome in Driving Breast Cancer Progression | PDF",1790243645,43]