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Methods: Narrative review using PubMed to identify evidence-based analyses and trials from inception to September 1, 2022, with emphasis on guideline-referenced studies. Results: Smoking correlates with worse prostate features and affects recurrence and cancer-specific mortality; it is strongly linked to bladder cancer and poorer outcomes; it is associated with renal tumorigenesis, higher grade/stage, and higher recurrence; and it is linked to UTUC tumorigenesis and advanced disease with reduced survival. Conclusion: Smoking is associated with more aggressive urologic cancers and recurrence; the protective role of cessation remains unclear but likely beneficial.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/impact-of-smoking-on-urologic-cancers-a-snapshot-of-current-evidence/378914/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/impact-of-smoking-on-urologic-cancers-a-snapshot-of-current-evidence/378914.png","ImageObject",300,407,{"name":92,"@type":93},"River Wang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-02","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Which urologic cancers are examined in the review?","Question",{"text":113,"@type":114},"The paper focuses on prostate, bladder, renal, and upper tract urothelial cancer (UTUC).","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What evidence links smoking to prostate cancer outcomes?",{"text":118,"@type":114},"Multiple studies associate smoking with higher Gleason score, higher tumor stage, and extracapsular invasion, with evidence suggesting roles in biochemical recurrence and cancer-specific mortality.",{"name":120,"@type":111,"acceptedAnswer":121},"How does the review describe the role of smoking cessation?",{"text":122,"@type":114},"The role of smoking cessation is still unclear, but it appears to provide some protective effect; the review highlights the opportunity for urologists to encourage cessation practices.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},378914,1790246663,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099514067438,"https://ap-avatar.wpscdn.com/avatar/100002539ee87300030?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780474512215547542","World Journal of Urology (2023) 41:1473–1479  \n[https://doi.org/10.1007/s00345-023-04406-y](https://doi.org/10.1007/s00345-023-04406-y)  \nImpact of smoking on urologic cancers: a snapshot of current evidence  \nRaj Kumar1 · Richard Matulewicz2 · Andrea Mari3 · Marco Moschini4 · Saum Ghodoussipour5 · Benjamin Pradere6 · Michael Rink7 · Riccardo Autorino8 · Mihir M. Desai1 · Inderbir Gill1 · Giovanni E. Cacciamani1  \nReceived: 27 September 2022 / Accepted: 6 April 2023 / Published online: 24 April 2023 © The Author(s) 2023  \nAbstract  \nPurpose The purpose of this paper is to present evidence regarding the associations between smoking and the following urologic cancers: prostate, bladder, renal, and upper tract urothelial cancer (UTUC) .  \nMethods This is a narrative review. PubMed was queried for evidence-based analyses and trials regarding the associations between smoking and prostate, bladder, renal, and UTUC tumors from inception to September 1, 2022. Emphasis was placedon articles referenced in national guidelines and protocols.  \nResults Prostate—multiple studies associate smoking with higher Gleason score, higher tumor stage, and extracapsular invasion. Though smoking has not yet been linked to tumorigenesis, there is evidence that it plays a role in biochemical recurrence and cancer-specific mortality. Bladder—smoking is strongly associated with bladder cancer, likely due to DNA damage from the release of carcinogenic compounds. Additionally, smoking has been linked to increased cancer-specific mortality and higher risk of tumor recurrence. Renal—smoking tobacco has been associated with tumorigenesis, higher tumor grade and stage, poorer mortality rates, and a greater risk of tumor recurrence. UTUC—tumorigenesis has been associated with smoking tobacco. Additionally, more advanced disease, higher stage, lymph node metastases, poorer survival outcomes, and tumor recurrence have been linked to smoking.  \nConclusion Smoking has been shown to significantly affect most urologic cancers and has been associated with more aggressive disease, poorer outcomes, and tumor recurrence. The role of smoking cessation is still unclear, but appears to provide some protective effect. Urologists have an opportunity to engage in primary prevention by encouraging cessation practices.  \nKeywords Smoking · Urologic oncology · Tumor recurrence · Smoking cessation  \n* Giovanni E. Cacciamani [giovanni.cacciamani@med.usc.edu](giovanni.cacciamani@med.usc.edu)  \n1 The Catherine and Joseph Aresty Department of Urology, USC Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, USA  \n2 Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center, New York, NY, USA  \n3 Department of Urology, Careggi Hospital, University of Florence, Florence, Italy  \n4 Department of Urology, La Croix du Sud Hospital,  \n31130 Quint Fonsegrives, France  \n5 Bladder and Urothelial Cancer Program, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA  \n6 Department of Urology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria  \n7 Department of Urology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany  \n8 Division of Urology, Department of Surgery, Virginia Commonwealth University, Richmond, VA, USA  \nIntroduction  \nThe association between smoking tobacco and urologic cancers has been extensively studied. While it is well known that smoking is among the leading predisposing factors for bladder cancer, prostate cancer, renal cancer, and upper tract urothelial cancer (UTUC) [1–4], the impact of smoking tobacco can be manifold as it may affect several stages in cancer therapy. In addition to tumorigenesis, smoking may also lead to poor surgical outcomes, prolonged recovery periods, increased complication rate, poor response to chemotherapy, and potentially have an impact on recurrence [5–8] . Studies and publications regarding urologic cancersand smoking have gradually been on ","cbCaidfBn2Odq0bA","https://ap.wps.com/l/cbCaidfBn2Odq0bA","pdf",527835,"English","# Introduction\n## Smoking as a risk factor for urologic cancers\n## Evolving tobacco consumption methods and emerging evidence\n## Role of urologists in smoking cessation\n# Purpose\n# Methods\n# Results\n## Prostate cancer\n## Bladder cancer\n## Renal cancer\n## Upper tract urothelial cancer (UTUC)\n# Conclusion\n# Keywords","[{\"question\":\"Which urologic cancers are examined in the review?\",\"answer\":\"The paper focuses on prostate, bladder, renal, and upper tract urothelial cancer (UTUC).\"},{\"question\":\"What evidence links smoking to prostate cancer outcomes?\",\"answer\":\"Multiple studies associate smoking with higher Gleason score, higher tumor stage, and extracapsular invasion, with evidence suggesting roles in biochemical recurrence and cancer-specific mortality.\"},{\"question\":\"How does the review describe the role of smoking cessation?\",\"answer\":\"The role of smoking cessation is still unclear, but it appears to provide some protective effect; the review highlights the opportunity for urologists to encourage cessation practices.\"}]","Impact of smoking on urologic cancers - a snapshot of current evidence | PDF",1790233259,18]