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Because multi-cancer early detection (MCED) shows higher sensitivity for poor-prognosis cancers and because cancer burden is greater in deprived groups, MCED programmes may deliver larger relative gains. The study models differential MCED benefits by deprivation level at varying participation levels across England.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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question does the study address about MCED screening?","Question",{"text":63,"@type":64},"It estimates whether the mortality and late-stage diagnosis benefits of an MCED screening programme differ across socioeconomic deprivation groups in England and how those benefits change with participation levels.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were the benefits of screening modelled?",{"text":68,"@type":64},"The interception multi-cancer screening model was applied to cancer incidence and survival data to estimate reductions in late-stage diagnoses and cancer mortality across 24 cancer types, by deprivation group.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the results show about the size of benefits across deprivation levels?",{"text":72,"@type":64},"Modelled benefits were largest in the most deprived group at every participation level, with reductions in late-stage diagnoses and cancer mortality declining as screening participation 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multi-cancer early detection test by socioeconomic group in England  \nRebecca Smittenaar, 1 Samantha L Quaife,2 Christian von Wagner  ,3 Thomas Higgins,4 Earl Hubbell, 5 Lennard Lee6  \n► Additional supplemental material is published online only. To view, please visit the journal online ([https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.1136/jech-2023-220834](10.1136/jech-2023-220834)) .  \n1GRAIL Bio UK Ltd, a subsidiary of GRAIL, LLC, London, UK 2Queen Mary University of London, London, UK 3University College London, London, UK  \n4National Cancer Registration and Analysis Service, Leeds, UK 5GRAIL, LLC, Menlo Park, California, USA  \n6NHS England, London, UK  \nCorrespondence to  \nDr Rebecca Smittenaar, GRAIL Bio UK, a subsidiary of GRAIL, LLC, London NW1 2DA, UK; [csmittenaar@](csmittenaar@grailbio.com)[grailbio.com](csmittenaar@grailbio.com)  \nReceived 11 May 2023 Accepted 10 February 2024 Published Online First  \n1 March 2024  \n© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.  \nTo cite: Smittenaar R, Quaife SL, von Wagner C, et al. J Epidemiol Community Health 2024;78:345–353 .  \nABSTRACT  \nBackground Cancer burden is higher and cancer screening participation is lower among individuals living in more socioeconomically deprived areas of England, contributing to worse health outcomes and shorter life expectancy. Owing to higher multi-cancer early detection (MCED) test sensitivity for poor-prognosis cancers and greater cancer burden in groups experiencing greater deprivation, MCED screening programmes may have greater relative benefits in these groups. We modelled potential differential benefits of MCED screening between deprivation groups in England at different levels of screening participation.  \nMethods We applied the interception multi-cancer screening model to cancer incidence and survival data made available by the National Cancer Registration and Analysis Service in England to estimate reductions in late-stage diagnoses and cancer mortality from an MCED screening programme by deprivation group across 24 cancer types. We assessed the impact of varying the proportion of people who participated in annual screening in each deprivation group on these estimates.  \nResults The modelled benefits of an MCED screening programme were substantial: reductions in late-stage diagnoses were 160 and 274 per 100 000 persons in the least and most deprived groups, respectively. Reductions in cancer mortality were 60 and 99 per 100 000 persons in the least and most deprived groups, respectively. Benefits were greatest in the most deprived group at every participation level and were attenuated with lower screening participation. Conclusions For the greatest possible population benefit and to decrease health inequalities, an MCED implementation strategy should focus on enhancing equitable, informed participation, enabling equal participation across all socioeconomic deprivation groups.  \nTrial registration number NCT05611632 .  \nINTRODUCTION  \nIn England, the difference in life expectancy between those living in the most and least deprived areas is approximately 8 years for women and 10 years for men.1 Cancer burden is one contributing factor, with an estimated 16 800 extra cancer cases each year attributable to deprivation, and a 16–19% gap in the incidence rate between groups experiencing the most and least deprivation.2 Some cancers, including bladder, breast, colon, rectal, ovarian and prostate cancers and melanoma, are diagnosed at a later stage in groups with higher deprivation.3  \nThe National Health Service (NHS) delivers nationally organised and quality-assured  \n\n| WHAT IS ALREADY KNOWN ON THIS TOPIC |\n| --- |\n| ⇒ Multi-cancer early detection (MCED)-based screening has the potential to substantially reduce late-stage cancer diagnosis and morta","cbCaiqXAEJwQquWU","https://ap.wps.com/l/cbCaiqXAEJwQquWU","pdf",1258146,"English","# ABSTRACT\n## Background\n## Methods\n## Results\n## Conclusions\n# INTRODUCTION\n# WHAT IS ALREADY KNOWN ON THIS TOPIC\n# WHAT THIS STUDY ADDS\n# HOW THIS STUDY MIGHT AFFECT RESEARCH, PRACTICE OR POLICY","[{\"question\":\"What question does the study address about MCED screening?\",\"answer\":\"It estimates whether the mortality and late-stage diagnosis benefits of an MCED screening programme differ across socioeconomic deprivation groups in England and how those benefits change with participation levels.\"},{\"question\":\"How were the benefits of screening modelled?\",\"answer\":\"The interception multi-cancer screening model was applied to cancer incidence and survival data to estimate reductions in late-stage diagnoses and cancer mortality across 24 cancer types, by deprivation group.\"},{\"question\":\"What did the results show about the size of benefits across deprivation levels?\",\"answer\":\"Modelled benefits were largest in the most deprived group at every participation level, with reductions in late-stage diagnoses and cancer mortality declining as screening participation decreased.\"}]","Impact of screening participation on modelled mortality benefits of a multi-cancer early detection test by socioeconomic group in England | PDF",1790002200,23]