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Consecutive PCI patients (2014–2021) were compared across LVEDP ≤14 mm Hg, 15–20 mm Hg, and >20 mm Hg groups, with supplemental analysis by LV ejection fraction among LVEDP >20 mm Hg patients.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/impact-of-left-ventricular-end-diastolic-pressure-on-percutaneous-coronary-intervention-outcomes/434225/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/impact-of-left-ventricular-end-diastolic-pressure-on-percutaneous-coronary-intervention-outcomes/434225.png","ImageObject",300,407,{"name":42,"@type":43},"Connor ","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-04","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",14,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the study’s primary outcome measure?","Question",{"text":63,"@type":64},"The primary outcome was all-cause mortality at 1 year after PCI.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were patients grouped by LVEDP?",{"text":68,"@type":64},"Patients were compared across three LVEDP categories: ≤14 mm Hg, 15–20 mm Hg, and >20 mm Hg.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the results show about mortality with higher LVEDP?",{"text":72,"@type":64},"Higher LVEDP was associated with increased 1-year all-cause mortality, with the highest mortality observed in the LVEDP >20 mm Hg group.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},434225,1791033220,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":116,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},687207022233,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Journal of the Society for Cardiovascular Angiography & Interventions 4 (2025) 104017  \nOriginal Research  \nImpact of Left Ventricular End-Diastolic Pressure on Percutaneous Coronary Intervention Outcomes  \nMatthew Siano, MD a, Yash Jobanputra, MD a, Angelo Oliva, MD a, b,  \nSamantha Sartori, PhD a, Kenneth Smith, MPH a, Harleen Kaur, BA a, Joseph Sweeny, MD a, George D. Dangas, MD, PhD a, Roxana Mehran, MD a, Annapoor na S. Kini, MD a, Samin K. Sharma, MD a, *  \na Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, New York; b Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy  \n| A B S T R A C T |\n| --- |\n| Background: Left ventricular end-diastolic pressure (LVEDP) is associated with adverse outcomes following percutaneous coronary intervention (PCI) for acute coronary syndrome (ACS) . We evaluated the impact of LVEDP on outcomes in patients with chronic coronary syndrome or ACS undergoing PCI. Methods: Consecutive patients undergoing PCI between 2014 and 2021 were included. Patients with LVEDP ≤14 mm Hg were compared to those with LVEDP 15 to 20 mm Hg and LVEDP >20 mm Hg. The primary outcome was all-cause mortality at 1 year. A supplemental analysis was conducted in patients with LVEDP >20 mm Hg according to left ventricular ejection fraction.\u003Cbr>Results: There were significant differences in baseline characteristics between patients with LVEDP ≤14 mm Hg (n = 10,547), LVEDP 15 to 20 mm Hg (n = 5011), and LVEDP >20 mm Hg (n = 1621) . Patients with LVEDP >20 mm Hg had the highest prevalence of comorbidities and complexity of coronary artery disease. Compared to patients with LVEDP ≤14 mm Hg, increased all-cause mortality was observed in patients with LVEDP 15 to 20 mm Hg (3.0% vs 1.6%; adjusted hazard ratio [aHR], 1.47; 95% CI, 1.15-1.87; P = .002) and LVEDP >20 mm Hg (7.6% vs 1.6%, aHR, 3.00; 95% CI, 2.31-3.90; P \u003C .001) at 1 year. Inpatients with LVEDP >20 mm Hg, a left ventricular ejection fraction \u003C40% was associated with increased 1-year all-cause mortality (11.4% vs 2.8%; aHR, 2.71; 95% CI, 1.36-5.37; P = .004) .\u003Cbr>Conclusions: In a population of patients with chronic coronary syndrome and ACS undergoing PCI, elevated LVEDP was associated with increased mortality at 1 year. Systolic dysfunction was associated with higher mortality in patients with LVEDP >20 mm Hg. |\n\nIntroduction  \nLeft ventricular end-diastolic pressure (LVEDP) is an important marker of left ventricular function, which is routinely measured during cardiac catheterization. Primarily determined by chamber compliance, it provides information on left ventricular filling conditions and diastolic function.1 The LVEDP is related to left ventricular systolic function, as reduced myocardial contractility affects the end-diastolic pressure-volume relationship, resulting in an upward shift of the pressure-volume loop and end-diastolic pressure point.1 It also sharesan inverse physiologic relationship with myocardial perfusion, which is determined by the diastolic pressure gradient between the aorta and  \nleft ventricle.2 The LVEDP can be elevated in numerous chronic conditions, such as concentric hypertrophy from hypertension or aortic stenosis, and restrictive or infiltrative cardiomyopathy.1 It is dynamic and can be elevated in the setting of acute myocardial ischemia, where diastolic dysfunction has been shown to precede systolic dysfunction,3 whether induced with rapid atrial pacing4 or from ST-segment elevation myocardial infarction (STEMI), in which it has been evaluated as a prognostic marker.5  \nLeft ventricular end-diastolic pressure has been associated with adverse outcomes following percutaneous coronary intervention (PCI) for STEMI or acute coronary syndrome (ACS) in most,2,5–10 but not all,11, 12 studies. Although prior work has examined outcomes  \nAbbreviations: ACS, acute coronary syndrome; CCS, chronic coronary syndrome; LVEDP, left ventricular end-diastolic p","cbCaim5is7UbZD2R","https://ap.wps.com/l/cbCaim5is7UbZD2R","pdf",2544840,"English","# Abstract\n# Introduction\n# Materials and methods\n## Study population and design","[{\"question\":\"What was the study’s primary outcome measure?\",\"answer\":\"The primary outcome was all-cause mortality at 1 year after PCI.\"},{\"question\":\"How were patients grouped by LVEDP?\",\"answer\":\"Patients were compared across three LVEDP categories: ≤14 mm Hg, 15–20 mm Hg, and \\u003e20 mm Hg.\"},{\"question\":\"What did the results show about mortality with higher LVEDP?\",\"answer\":\"Higher LVEDP was associated with increased 1-year all-cause mortality, with the highest mortality observed in the LVEDP \\u003e20 mm Hg group.\"}]","Impact of Left Ventricular End-Diastolic Pressure on Percutaneous Coronary Intervention Outcomes | PDF",1790667946,23]