[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-382557-105":59,"doc-detail-382557-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","impact-of-exosome-therapy-on-pancreatic-cancer-and-its-progression","Impact of exosome therapy on pancreatic cancer and its progression","","Pancreatic cancer is an aggressive disease with poor outcomes driven by limited early identification, rapid progression, surgical challenges, and insufficient effectiveness of existing oncologic therapies. Reliable imaging methods or biomarkers for accurately classifying and predicting tumor behavior are lacking. Exosomes, extracellular vesicles, contribute to progression, metastasis, and chemoresistance, and are supported as potential biomarkers. Their molecular cargo—including proteins, nucleic acids, and miRNAs—may guide prognostic grading. This review summarizes exosome components, secretion, isolation, functions in pancreatic cancer, and discusses exosomal miRNAs and their promise for precise clinical treatment.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/impact-of-exosome-therapy-on-pancreatic-cancer-and-its-progression/382557/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/impact-of-exosome-therapy-on-pancreatic-cancer-and-its-progression/382557.png","ImageObject",300,407,{"name":92,"@type":93},"\tCallum ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",18,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is early detection of pancreatic cancer difficult, according to the abstract?","Question",{"text":113,"@type":114},"It cites low rates of early identification, fast progression, difficulties after surgery, and the ineffectiveness of current therapies, with no imaging techniques or biomarkers that can accurately identify, categorize, or predict tumor behavior.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What role do exosomes play in pancreatic cancer progression and treatment response?",{"text":118,"@type":114},"Exosomes are described as extracellular vesicles involved in progression, metastasis, and chemoresistance. Their components can regulate tumor growth, metastasis, and angiogenesis.",{"name":120,"@type":111,"acceptedAnswer":121},"How might exosomes be used as biomarkers for pancreatic cancer?",{"text":122,"@type":114},"The abstract states that exosomes have been verified as potential biomarkers for management, including their molecular cargo such as proteins, DNA, mRNA, microRNA, long non-coding RNA, and exosomal miRNAs for prognosis and grading.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},382557,1790464407,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},137451211410,"https://ap-avatar.wpscdn.com/avatar/2000bb0a9246f588df?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786362646172706240","Medical Oncology (2023) 40:225  \n[https://doi.org/10.1007/s12032-023-02101-x](https://doi.org/10.1007/s12032-023-02101-x)  \nImpact of exosome therapy on pancreatic cancer and its progression  \nMohamed El‑Tanani1,2,3 · Hamdi Nsairat1 · Ismail I. Matalka3,4 · Alaa A. A. Aljabali5 · Vijay Mishra6 · Yachana Mishra7 · Gowhar A. Naikoo8 · Sai Raghuveer Chava9 · Nitin B. Charbe10 · Murtaza M. Tambuwala11  \nReceived: 25 April 2023 / Accepted: 19 May 2023 / Published online: 5 July 2023 © The Author(s) 2023  \nAbstract  \nPancreatic cancer, one of the most aggressive tumors, has a dismal prognosis because of the low rates of early identification, fast progression, difficulties following surgery, and the ineffectiveness of current oncologic therapies. There are no imaging techniques or biomarkers that can accurately identify, categorize, or predict the biological behavior of this tumor. Exosomes are extracellular vesicles that play a crucial rule in the progression, metastasis, and chemoresistance of pancreatic cancer. They have been verified to be potential biomarkers for pancreatic cancer management. Studying the role of exosomes in pancreatic cancer is substantial. Exosomes are secreted by most eukaryotic cells and participated in intercellular communication. The components of exosomes, including proteins, DNA, mRNA, microRNA, long non-coding RNA, circular RNA, etc., play a crucial role in regulating tumor growth, metastasis, and angiogenesis in the process of cancer development, and can be used as a prognostic marker and/or grading basis for tumor patients. Hereby, in this concise review, we intend to summarize exosomes components and isolation, exosome secretion, function, importance of exosomes in the progression of pancreatic cancer and exosomal miRNAs as possible pancreatic cancer biomarkers. Finally, the application potential of exosomes in the treatment of pancreatic cancer, which provides theoretical supports for using exosomes to serve precise tumor treatment in the clinic, will be discussed.  \nKeywords Exosomes · Pancreatic cancer · Intercellular communication · Biomarkers · Folfirinox · Gemcitabine  \n*  \n*  \n1  \n2  \n3  \n4  \n5  \nMohamed El-Tanani  \n[m.tanani@ammanu.edu.jo](m.tanani@ammanu.edu.jo)  \nMurtaza M. Tambuwala[mtambuwala@lincoln.ac.uk](mtambuwala@lincoln.ac.uk)  \nPharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al–Ahliyya Amman University, Amman 19328, Jordan  \nInstitute of Cancer Therapeutics, University of Bradford, Bradford BD7 1DP, West Yorkshire, UK  \nRas Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, UAE  \nDepartment of Pathology and Microbiology, Faculty of Medicine, Jordan University of Science and Technology, Irbid 22110, Jordan  \nDepartment of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Yarmouk University, P.O. Box 566, Irbid 21163, Jordan  \n6 School of Pharmaceutical Sciences, Lovely Professional University, Phagwara 144411, India  \n7 Department of Zoology, School of Bioengineering and Biosciences, Lovely Professional University, Phagwara 144411, India  \n8 Department of Mathematics and Sciences, College of Arts and Applied Sciences, Dhofar University, PC 211, Salalah, Oman  \n9 Department of Chemistry, Texas A&M University, Kingsville, TX, USA  \n10 Department of Pharmaceutics, College of Pharmacy, Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, FL, USA  \n11 Lincoln Medical School, University of Lincoln, Brayford Pool Campus, Lincoln LN6 7TS, UK  \nIntroduction  \nPancreatic cancer is the sixth worst cancer in the world, according to statistics [1] . The most prevalent form of the disease is pancreatic ductal adenocarcinoma (PDAC) . If pancreatic surgery is performed and the cancer has not spread, pancreatic cancer patients diagnosed in the United Kingdom have a 7–25% probability of surviving five years [2] . Despite the fact that surgery has been shown to prolong life, only 20% of PDAC patients with respectable ","cbCaigsmDQ97oX9O","https://ap.wps.com/l/cbCaigsmDQ97oX9O","pdf",1355690,15,"English","# Abstract\n# Introduction\n# Components and isolation","[{\"question\":\"Why is early detection of pancreatic cancer difficult, according to the abstract?\",\"answer\":\"It cites low rates of early identification, fast progression, difficulties after surgery, and the ineffectiveness of current therapies, with no imaging techniques or biomarkers that can accurately identify, categorize, or predict tumor behavior.\"},{\"question\":\"What role do exosomes play in pancreatic cancer progression and treatment response?\",\"answer\":\"Exosomes are described as extracellular vesicles involved in progression, metastasis, and chemoresistance. Their components can regulate tumor growth, metastasis, and angiogenesis.\"},{\"question\":\"How might exosomes be used as biomarkers for pancreatic cancer?\",\"answer\":\"The abstract states that exosomes have been verified as potential biomarkers for management, including their molecular cargo such as proteins, DNA, mRNA, microRNA, long non-coding RNA, and exosomal miRNAs for prognosis and grading.\"}]","Impact of exosome therapy on pancreatic cancer and its progression | PDF",1790250994,38]