[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-371061-105":59,"doc-detail-371061-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","impact-of-essential-and-toxic-trace-elements-on-cervical-premalignant-lesions-research-findings","Impact of Essential and Toxic Trace Elements on Cervical Premalignant Lesions - Research findings","","Cervical intraepithelial neoplasia (CIN) represents a spectrum of precancerous cervical lesions in which timely detection and intervention are essential to prevent progression to invasive cervical cancer. The study quantifies trace elements in cervical tissue from patients diagnosed with CIN 2 and CIN 3 (n=60) and compares results with healthy control samples from the same cohort (n=60). Essential elements showed increased concentrations alongside toxic elements, suggesting involvement in CIN pathophysiological processes and supporting further mechanistic research.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/impact-of-essential-and-toxic-trace-elements-on-cervical-premalignant-lesions-research-findings/371061/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/impact-of-essential-and-toxic-trace-elements-on-cervical-premalignant-lesions-research-findings/371061.png","ImageObject",300,407,{"name":92,"@type":93},"dhado","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main objective of this study on CIN?","Question",{"text":113,"@type":114},"To determine the levels of essential and toxic trace elements in cervical tissue samples from patients with CIN 2 and CIN 3, and compare them with control samples.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were trace element concentrations measured?",{"text":118,"@type":114},"Concentrations of trace elements were determined using inductively coupled plasma–mass spectrometry (ICP-MS).",{"name":120,"@type":111,"acceptedAnswer":121},"What key differences were found between CIN tissues and controls?",{"text":122,"@type":114},"CIN 2 and CIN 3 tissues had significantly higher concentrations of several essential trace elements (Cr, Co, Se, Mo) and toxic trace elements (Be, Ni, Cd) compared with controls.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},371061,1790429562,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909893218464,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Article  \nImpact of Essential and Toxic Trace Elements on Cervical Premalignant Lesions  \nJovana Koci´c 1, Nebojša Zeˇcevi´c 1,2, Jovana Jagodi´c 3,*, Dejan Mihajlovi´c 4, Marko Dzuverovi´c 1, Nenad Pavlovi´c 1, Jelena Kotur-Stevuljevi´c 5, Dragan Manojlovi´c 3 and Aleksandar Stojsavljevi´c 6  \nAcademic Editor: Randolph C. Elble  \nReceived: 29 September 2025  \nRevised: 28 November 2025  \nAccepted: 5 December 2025  \nPublished: 9 December 2025  \nCitation: Koci´c, J.; Zeˇcevi´c, N.; Jagodi´c, J.; Mihajlovi´c, D.;  \nDzuverovi´c, M.; Pavlovi´c, N.;  \nKotur-Stevuljevi´c, J.; Manojlovi´c, D.; Stojsavljevi´c, A. Impact of Essential and Toxic Trace Elements on Cervical Premalignant Lesions. Biomedicines 2025, 13, 3015. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/biomedicines13123015](10.3390/biomedicines13123015)  \n[Copyright:](Copyright:) © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Clinic for Gynecology and Obstetrics “Narodni Front”, Kraljice Natalije 62, 11000 Belgrade, Serbia; [gasicjovana@gmail.com](gasicjovana@gmail.com) (J.K.); [nebojsa.zecevic1@gmail.com](nebojsa.zecevic1@gmail.com) (N.Z.); [dzuverovic.marko@gmail.com](dzuverovic.marko@gmail.com) (M.D.); [nenadpavlovic8822@gmail.com](nenadpavlovic8822@gmail.com) (N.P.)  \n2 Faculty of Medicine, University of Belgrade, Doktora Suboti´ca 8, 11000 Belgrade, Serbia  \n3 Faculty of Chemistry, University of Belgrade, Studentski Trg 12-16, 11000 Belgrade, Serbia; [manojlo@chem.bg.ac.rs](manojlo@chem.bg.ac.rs)  \n4 Clinical Hospital Center Kosovska Mitrovica, Anri Dinana 10, 38220 Kosovska Mitrovica, Serbia; [dejan.mihajlovic@med.pr.ac.rs](dejan.mihajlovic@med.pr.ac.rs)  \n5 Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11000 Belgrade, Serbia; [jkotur@pharmacy.bg.ac.rs](jkotur@pharmacy.bg.ac.rs)  \n6 Innovative Centre, Faculty of Chemistry, University of Belgrade, Studentski Trg 12-16, 11000 Belgrade, Serbia; [aleksandars@chem.bg.ac.rs](aleksandars@chem.bg.ac.rs)  \n* [Correspondence: jovanaj@chem.bg.ac.rs](Correspondence: jovanaj@chem.bg.ac.rs)  \nAbstract  \nBacground/Objectives: Cervical intraepithelial neoplasia (CIN) comprises a range of precancerous cervical lesions, and timely detection and intervention are essential to avert the development to invasive cervical cancer. Our previous study showed specific elemental alterations in the serum of patients with diagnosed CIN. In this study, we aimed to determine the levels of trace elements (Be, Cr, Mn, Co, Ni, Cu, Zn, Se, Cd, Tl, Pb, Rb, Sr, Mo, Th, and U) in more valuable materials, cervical tissue samples collected from patients diagnosed with CIN 2 and 3 (n = 60) . Methods: The control group consisted of healthy, pathologically unaltered samples from the same patients (n = 60) . The concentrations of all trace elements were determined using inductively coupled plasma–mass spectrometry (ICP-MS) . Key demographic and clinical data were statistically analyzed in the context of trace element levels in cervical tissues. Results: We discovered that CIN 2 and CIN 3 tissues had significantly higher concentrations of essential trace elements Cr, Co, Se, and Mo, and toxic trace elements Be, Ni, and Cd compared to controls. The findings of this study highlight the differences in trace element concentrations in CIN tissue samples compared to controls. Conclusions: The presented results suggest the possible role of trace elements in the pathophysiological processes that lead to neoplasms in cervical tissues. The results provide initial and pivotal insight into the trace element concentrations in CIN tissues, which could aid further studies regarding cervical neoplasms and their pathogenesis.  \nKeywords: cervical intraepithelial neo","cbCaiq9WkpDAwZJu","https://ap.wps.com/l/cbCaiq9WkpDAwZJu","pdf",375514,"English","# Abstract\n## Objectives\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What is the main objective of this study on CIN?\",\"answer\":\"To determine the levels of essential and toxic trace elements in cervical tissue samples from patients with CIN 2 and CIN 3, and compare them with control samples.\"},{\"question\":\"How were trace element concentrations measured?\",\"answer\":\"Concentrations of trace elements were determined using inductively coupled plasma–mass spectrometry (ICP-MS).\"},{\"question\":\"What key differences were found between CIN tissues and controls?\",\"answer\":\"CIN 2 and CIN 3 tissues had significantly higher concentrations of several essential trace elements (Cr, Co, Se, Mo) and toxic trace elements (Be, Ni, Cd) compared with controls.\"}]","Impact of Essential and Toxic Trace Elements on Cervical Premalignant Lesions - Research findings | PDF",1790191154,28]