[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-461694-105":59,"doc-detail-461694-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","impact-of-cytokine-genes-on-tmd-and-qol-in-construction-workers","Impact of Cytokine Genes on TMD and QoL in Construction Workers","","Temporomandibular disorders (TMD) involve orofacial pain, restricted mouth opening, and inflammatory processes mediated by interleukins. Genetic polymorphisms in interleukin-related genes may therefore influence both TMD occurrence and oral health-related quality of life (OHRQoL). This cross-sectional study evaluated 230 male construction workers using RDC/TMD, and measured OHRQoL with OHIP-14. DNA from saliva assessed IL1B and IL6 polymorphisms by real-time PCR, with statistical testing at alpha=5%.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/impact-of-cytokine-genes-on-tmd-and-qol-in-construction-workers/461694/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/impact-of-cytokine-genes-on-tmd-and-qol-in-construction-workers/461694.png","ImageObject",300,407,{"name":92,"@type":93},"CatatanPagi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the study’s main goal regarding TMD and quality of life?","Question",{"text":113,"@type":114},"To assess how genetic polymorphisms in cytokine-encoding genes relate to oral health-related quality of life in individuals with TMD.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were TMD and OHRQoL evaluated in the construction workers?",{"text":118,"@type":114},"TMD was assessed using RDC/TMD, and OHRQoL was measured with the OHIP-14 questionnaire.",{"name":120,"@type":111,"acceptedAnswer":121},"Which genetic polymorphisms were analyzed, and how were they tested?",{"text":122,"@type":114},"IL1B (rs1143627, rs1143629) and IL6 (rs1800795, rs1800796) polymorphisms were evaluated using DNA extracted from saliva with real-time PCR.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},461694,1791028744,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},962090894170,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Brazilian Dental Journal. Volume 36 (2025), e25-6581 [http://dx.doi.org/10.1590/0103-644020256581](http://dx.doi.org/10.1590/0103-644020256581)  \nISSN 0103-6440   \nImpact of Cytokine Genes on TMD and QoLin Construction Workers  \nAndré Miquilussi Moreira1, Samantha Schaffer Pugsley Baratto2, Débora Cristina Cardozo Bueno1, Gisele Maria Correr3, Cristiano Miranda de Araujo1,4, Christian Kirschneck5, Bianca CavalcanteLeão1, Erika Calvano Küchler5, Flares Baratto-Filho1,4, Michelle Nascimento Megerx1.  \nTemporomandibular disorders (TMD) include changes related to the presence of orofacial pain, limited mouth opening, and inflammatory issues. These inflammatory issues are related to interleukins, which are inflammatory mediators. Thus, the presence of genetic polymorphisms in genes that encode interleukins could impact TMD. Therefore, this cross-sectional study aimed to assess the impact of genetic polymorphisms in the genes encoding interleukinson the oral health-related quality of life (OHRQoL) of individuals with TMD. A total of 230 male construction workers were evaluated regarding the presence of TMD with or without pain, as well as changes in the temporomandibular joint (TMJ), using the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) . OHRQoL was assessed using the 14-item Oral Health Impact Profile (OHIP-14) . DNA extracted from saliva was used to evaluate the genetic polymorphisms in IL1B (rs1143627 and rs1143629) and IL6 (rs1800795 and rs1800796) using real-time polymerase chain reaction. Student's t-test or ANOVA was used for statistical analysis (alpha=5%) . An association between OHIP-14 and TMD was observed (p\u003C0 .05) . Individuals’ heterozygous AG in rs1143629 showed increased values in domains 2 (physical pain) and 4 (physical disability) compared to AA homozygotes (p=0 .035; p=0 .042, respectively) . Individuals homozygous for the C allele at rs1800796 demonstrated higher values in domain 7 (handicap) compared to heterozygous CG and homozygous GG individuals (p=0 .007) . In conclusion, our study supported the hypothesis that TMD and genetic polymorphisms associated with inflammatory disorders are associated with OHRQoL.  \n1 School of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil.  \n2 School of Dentistry, UniDomBosco University Center, Curitiba, Paraná, Brazil.  \n3 Department of Restorative Dentistry, Federal University of Paraná, Curitiba, Paraná, Brazil.  \n4 School of Dentistry University of Joinville, Joinville, Santa Catarina, Brazil.  \n5 Department of Orthodontics, University Hospital Bonn, Medical Faculty, Welschnonnenstr. 17, 53111, Bonn, Germany.  \nCorrespondence: Flares Baratto-Filho. School of Dentistry, Tuiuti University of Paraná, Curitiba, Paraná, Brazil. Padre Ladislau Kula St., 395 - 82010-210-Phone: +55 41 3331-7700. E-mail: [fbaratto1@gmail.com](fbaratto1@gmail.com)  \nKey Words: Temporomandibular joint disorders; Interleukin-1 beta; Interleukin-6; Quality of life; Genetics  \nIntroduction  \nTemporomandibular disorders (TMDs) encompass a heterogeneous group of musculoskeletal conditions affecting the temporomandibular joint (TMJ), masticatory muscles, and associated structures. Characterized by symptoms such as orofacial pain, joint noises, and restricted jaw movement, TMDs can significantly impair essential functions such as chewing and speech (1, 2) . Consequently, these disorders often have a detrimental impact on an individual's Oral Health-Related Quality of Life (OHRQoL), affecting psychological well-being and social functioning (3-5) . The etiology of TMDs is multifactorial, involving a complex interplay of biological, psychosocial, and environmental factors, including genetic predispositions (2) .  \nA standardized assessment is essential for both clinical management and research consistency. To this end, the Research Diagnostic Criteria (RDC/TMD) provides a validated dual-axis system. Axis I focuses on the clinical diagnosis of physical conditions based ","cbCaipf1mvnAumNr","https://ap.wps.com/l/cbCaipf1mvnAumNr","pdf",642692,11,"English","# Introduction\n## Temporomandibular disorders and OHRQoL\n## Standardized diagnosis with RDC/TMD\n## OHIP-14 patient-reported outcomes\n## Inflammation and cytokines in TMD\n## Genetic polymorphisms and individual susceptibility","[{\"question\":\"What is the study’s main goal regarding TMD and quality of life?\",\"answer\":\"To assess how genetic polymorphisms in cytokine-encoding genes relate to oral health-related quality of life in individuals with TMD.\"},{\"question\":\"How were TMD and OHRQoL evaluated in the construction workers?\",\"answer\":\"TMD was assessed using RDC/TMD, and OHRQoL was measured with the OHIP-14 questionnaire.\"},{\"question\":\"Which genetic polymorphisms were analyzed, and how were they tested?\",\"answer\":\"IL1B (rs1143627, rs1143629) and IL6 (rs1800795, rs1800796) polymorphisms were evaluated using DNA extracted from saliva with real-time PCR.\"}]","Impact of Cytokine Genes on TMD and QoL in Construction Workers | PDF",1790762173,28]