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Methods: Retrospective international multicentre comparison of non-therapeutic laparotomy versus no surgery and versus resection. Results: No significant survival reduction versus non-surgical care; resection showed better outcomes.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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of a non-therapeutic laparotomy in patients with locally advanced pancreatic cancer treated with induction (m)FOLFIRINOX  \nPublished in:  \nBritish Journal of Surgery  \nPublication status and date:  \nPublished: 01/03/2024  \nDOI (link to publisher):  \n10.1093/bjs/znae033  \nDocument Version  \nPublisher's PDF, also known as Version of record  \nDocument License/Available under:  \nCC BY  \nCitation for the published version (APA):  \nTheijse, R. T. , Stoop, T. F. , Janssen, Q. P. , Prakash, L. R. , Katz, M. H. G. , Doppenberg, D. , Tzeng, C. W. D. , Wei, A. C. , Zureikat, A. H. , Koerkamp, B. G. , & Besselink, M. G. (2024) . Impact of a non-therapeutic laparotomy in patients with locally advanced pancreatic cancer treated with induction (m)FOLFIRINOX: Trans-Atlantic Pancreatic Surgery (TAPS) Consortium  \nstudy. British Journal of Surgery, 111(3), Article znae033 . [https://doi.org/10.1093/bjs/znae033](https://doi.org/10.1093/bjs/znae033)  \nLink to publication on the EUR Research Information Portal  \nTerms and Conditions of Use  \nExcept as permitted by the applicable copyright law, you may not reproduce or make this material available to any third party without the prior written permission from the copyright holder(s) . Copyright law allows the following uses of this material without prior permission:  \n• you may download, save and print a copy of this material for your personal use only;  \n• you may share the EUR portal link to this material.  \nIn case the material is published with an open access license (e.g. a Creative Commons (CC) license), other uses may be allowed. Please check the terms and conditions of the specific license.  \nTake-down policy  \nIf you believe that this material infringes your copyright and/or any other intellectual property rights, you may request its removal by contacting us at the following email address: [openaccess.library@eur.nl. Please](openaccess.library@eur.nl. Please) provide us with all the relevant information, including the reasons why you believe any of your rights have been infringed. In case of a legitimate complaint, we will make the material inaccessible and/or remove it from the website.  \nBJS, 2024, znae033  \n[https://doi.org/10.1093/bjs/znae033](https://doi.org/10.1093/bjs/znae033)  \nOriginal Article  \nImpact of a non-therapeutic laparotomy in patients with locally advanced pancreatic cancer treated with induction (m)FOLFIRINOX: Trans-Atlantic Pancreatic Surgery (TAPS) Consortium study  \nRutger T. Theijse1,2, Thomas F. Stoop1,2,3 , Quisette P. Janssen4, Laura R. Prakash5, Matthew H. G. Katz5 , Deesje Doppenberg1,2, Ching-Wei D. Tzeng5, Alice C. Wei6 , Amer H. Zureikat7, Bas Groot Koerkamp4  and Marc G. Besselink1,2,*  on behalf of the Trans-Atlantic Pancreatic Surgery (TAPS) Consortium  \n1Department of Surgery, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands 2Cancer Center Amsterdam, Amsterdam, The Netherlands  \n3Division of Surgical Oncology, Department of Surgery, University of Colorado, Aurora, Colorado, USA 4Department of Surgery, Erasmus MC Cancer Institute, Rotterdam, The Netherlands  \n5Department of Surgical Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA 6Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA  \n7Division of Surgical Oncology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA  \n*Correspondence to: Marc G. Besselink, Department of Surgery, Amsterdam UMC, location University of Amsterdam, De Boelelaan 1117 (ZH-7F18), Amsterdam, 1081 HV, The Netherlands ([e-mail: m.g.besselink@amsterdamUMC.nl](e-mail: m.g.besselink@amsterdamUMC.nl))  \nPresented to the following international congresses: Pancreas Club, Chicago, IL, USA, May 2023; and Society for Surgery of the Alimentary Tract (SSAT), Chicago, IL, USA, May 2023.  \nAbstract  \nBackground: Surgery in selected patients with locally advanced pancreatic","cbCaiaenNHfVo8qp","https://ap.wps.com/l/cbCaiaenNHfVo8qp","pdf",318381,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What clinical problem does the study address?\",\"answer\":\"The study evaluates oncological consequences when patients with locally advanced pancreatic cancer undergo induction (m)FOLFIRINOX but end up with a non-therapeutic laparotomy because curative resection is not possible.\"},{\"question\":\"How was the research conducted and what groups were compared?\",\"answer\":\"A retrospective international multicentre design compared patients receiving non-therapeutic laparotomy with patients not undergoing surgery and with patients undergoing resection.\"},{\"question\":\"What were the key findings regarding survival?\",\"answer\":\"Non-therapeutic laparotomy was not associated with reduced overall survival compared with no surgery, while patients who underwent resection had longer overall survival and higher 5-year survival rates.\"}]","Impact of a non-therapeutic laparotomy in patients with locally advanced pancreatic cancer treated with induction (m)FOLFIRINOX - study | PDF",1789463641,25]