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Methods use a retrospective analysis of patients with at least two PHQ-9 scores in a 12-month window (Jan 2022–Dec 2023) on one regional campus, assessing response at 12 and 24 weeks.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/impact-of-a-collaborative-care-program-on-depression-outcomes-a-real-world-retrospective-analysis/363376/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/impact-of-a-collaborative-care-program-on-depression-outcomes-a-real-world-retrospective-analysis/363376.png","ImageObject",300,407,{"name":92,"@type":93},"supergirl","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main objective of this study?","Question",{"text":113,"@type":114},"To evaluate depression outcomes within a collaborative care program integrating behavioral health and palliative care at an academic cancer center.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was depression response defined and measured?",{"text":118,"@type":114},"Depression response was defined as a 50% reduction in PHQ-9 scores, assessed at 12 and 24 weeks.",{"name":120,"@type":111,"acceptedAnswer":121},"How did the outcomes compare with collaborative care randomized controlled trials (RCTs)?",{"text":122,"@type":114},"The study observed depression response rates comparable to those reported in RCTs of collaborative care for individuals with cancer.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},363376,1790460740,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962088121634,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Palliative and Supportive Care  \nImpact of a collaborative care program on depression outcomes: A real-world  \n[cambridge.org/pax](cambridge.org/pax)  \nOriginal Article  \n*These authors are regarded as co-first authors.  \nCite this article: Wu CC, Ketron A, Pirl W, Lally K, Cubbison C, Yusufov M (2026) Impact of a collaborative care program on depression outcomes: A real-world retrospective analysis. Palliative and Supportive Care 24, e57, 1–6 .  \n[https://doi.org/10.1017/S1478951526101709](https://doi.org/10.1017/S1478951526101709)  \nReceived: 6 January 2026  \nRevised: 6 January 2026  \nAccepted: 18 January 2026  \nKeywords:  \nCancer care; collaborative care; depression; integrated care; CoCM  \nCorresponding author: Carrie C. Wu;  \nEmail: [carriewumd@gmail.com](carriewumd@gmail.com)  \n© The Author(s), 2026 . Published by Cambridge University Press. This is an Open Access article, distributed under the terms of the Creative Commons AttributionNonCommercial-NoDerivatives licence ([http://](http://)[ ](http://)[creativecommons.org/licenses/by-nc-nd/4.0](creativecommons.org/licenses/by-nc-nd/4.0)), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use and/or adaptation of the article.  \nretrospective analysis  \nCarrie C. Wu, M. D.1 , 2 ,3 , * , Adam Ketron, M. D., PH. D.1 , 2 ,3 , *, William Pirl, M. D., MPH.4 , Kate Lally, M. D.1 , 2 ,5 , Caroline Cubbison, M. D.1 , 2 and Miryam Yusufov, PH. D.1 , 2  \n1 Department of Supportive Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; 2 Harvard Medical School, Boston, MA, USA; 3 Department of Psychiatry, Brigham and Women’s Hospital, Boston, MA, USA; 4 Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York City, NY, USA and 5 Division of Palliative Medicine, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA  \nAbstract  \nObjectives. Randomized controlled trials (RCTs) of the Collaborative Care Model demonstrate strong evidence for effectively managing depression in a stepped-care approach across diverse patient populations. Despite alignment with the American Society of Clinical Oncology guidelines, which recommend a stepped-care approach for managing depression and anxiety in cancer patients, implementation of collaborative care in cancer centers remains limited and sparse real-world data exist. The Supportive Oncology Collaborative, a program integrating behavioral health and palliative care, was developed at an NCI-designated academic cancer center. This study aims to evaluate depression outcomes within this collaborative care program. Methods. A retrospective analysis was conducted on patients with at least 2 Patient Health Questionnaire-9 (PHQ-9) scores recorded within a 12-month period between January 2022 and December 2023 at 1 regional campus. Depression response, defined as a 50% reduction in PHQ-9 scores, was assessed at 12 and 24 weeks. Response rates were compared to those reported in RCTs of collaborative care.  \nResults. Mean PHQ-9 scores were 17 .3 at baseline (n = 47), 11 . 1 at 12 weeks (n = 43), and 10.1 at 24 weeks (n = 22) . Depression response rates were 34.9% at 12 weeks (n = 43) and 54.5% at 24 weeks (n = 22) .  \nSignificance of results. We observed depression response rates comparable to those reported in RCTs of collaborative care in individuals with cancer. However, the high proportion of missing data highlights the difficulty of tracking outcomes in real-world clinical settings and the need for further evaluation and strategies to improve data completeness.  \nIntroduction  \nDepression is a major source of morbidity affecting daily functioning and quality of life in the general (i.e., nononcology) population. An estimated 8.4% of U.S. adults suffer from depression, ","cbCaibLLpjGgZEY1","https://ap.wps.com/l/cbCaibLLpjGgZEY1","pdf",750278,"English","# Abstract\n## Objectives\n## Methods\n## Results\n## Significance of results\n# Introduction","[{\"question\":\"What is the main objective of this study?\",\"answer\":\"To evaluate depression outcomes within a collaborative care program integrating behavioral health and palliative care at an academic cancer center.\"},{\"question\":\"How was depression response defined and measured?\",\"answer\":\"Depression response was defined as a 50% reduction in PHQ-9 scores, assessed at 12 and 24 weeks.\"},{\"question\":\"How did the outcomes compare with collaborative care randomized controlled trials (RCTs)?\",\"answer\":\"The study observed depression response rates comparable to those reported in RCTs of collaborative care for individuals with cancer.\"}]","Impact of a collaborative care program on depression outcomes: A real-world retrospective analysis | PDF",1790150998,15]