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The piece discusses results from a referenced bibliometric review covering 1999-2023 publications, focusing on publication counts, journals, study origins by country and scientific centers, and ongoing clinical trials. It also summarizes epidemiological trends and interprets etiological factors, outlines conservative chemotherapy approaches, and reviews management of resectable, locally advanced, and unresectable disease. 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Hellenic Society for Gastrointestinal Oncology, 354 Iera Odos, Chaidari 12461, Attica, Greece  \nManousos M Konstadoulakis, Second Department of Surgery, University of Athens School of Medicine, Aretaieion Hospital, Athens 11528, Attica, Greece  \nApostolos E Papalois, Unit of Surgical Research and Training, Second Department of Surgery, University of Athens, School of Medicine, Aretaieion Hospital, Athens 11528, Attica, Greece  \nCorresponding author: Apostolos E Papalois, DPhil, Visiting Professor, Unit of Surgical Research and Training, Second Department of Surgery, University of Athens, School of Medicine, Aretaieion Hospital, 76 Vas Sophias Avenue, Athens 11528, Attica, Greece.  \n[apostolospapalois@gmail.com](apostolospapalois@gmail.com)  \nAbstract  \nIn this editorial, we comment on the article entitled “Advances and key focus areas in gastric cancer immunotherapy: A comprehensive scientometric and clinical trial review (1999-2023),” which was published in the recent issue of the World Journal of Gastroenterology. We focused on the results of the authors’ bibliometric analysis concerning gastric cancer immunotherapy, which they analyzed in depth by compiling the relevant publications of the last 20 years. Before that, we briefly describe the most recent data concerning the epidemiological parameters of gastric cancer (GC) in different countries, attempting to give an interpretation based on the etiological factors involved in the etiopathogenesis of the neoplasm. We then briefly discuss the conservative treatment (chemotherapy) of the various forms of this malignant neoplasm. We describe the treatment of resectable tumors, locally advanced neoplasms, and unresectable (advanced) cases. Special attention is given to modern therapeutic approaches with emphasis on immunotherapy, which seems to be the future of GC treatment, especially in combination with chemotherapy. There is also a thorough analysis of the results of the study under review in terms of the number of scientific publications, the countries in which the studies were conducted, the authors, and the scientific centers of origin, as well asthe clinical studies in progress. Finally, an attempt is made to draw some conclusions and to point out possible future directions.  \nKey Words: Gastric cancer; Chemotherapy; Immunotherapy; Immune checkpoint inhibitors; Bibliometrics; Scientometrics  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 779 February 28, 2024  Volume 30  Issue 8   \nTriantafillidis JK et al. Gastric cancer and immunotherapy  \n©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Gastric cancer (GC) remains a major cause of morbidity and mortality worldwide. Conservative treatment in the form of chemotherapy has recently mad","cbCaibATjs8JQc0O","https://ap.wps.com/l/cbCaibATjs8JQc0O","pdf",962952,16,"English","# Editorial\n## Immunotherapy overview and future directions\n## Bibliometric review summary (1999-2023)\n## Epidemiology, risk factors, and treatment landscape\n## Clinical and scientific trial outlook","[{\"question\":\"What is the main purpose of this editorial?\",\"answer\":\"To comment on a referenced review and assess current status and future perspectives of gastric cancer immunotherapy, emphasizing both bibliometric findings and clinical trial directions.\"},{\"question\":\"Which aspects of the bibliometric study does the editorial focus on?\",\"answer\":\"The editorial highlights publication volume and types, journals, countries of origin, scientific centers, and the status of clinical studies in progress.\"},{\"question\":\"How does the editorial position immunotherapy within gastric cancer treatment?\",\"answer\":\"Immunotherapy is presented as a major and likely future approach, especially when combined with chemotherapy, across multiple disease stages.\"}]","Immunotherapy of gastric cancer - Present status and future perspectives | PDF",1790001566]