[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-342551-105":59,"doc-detail-342551-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","immunosurveillance-encounters-cancer-metabolism-review-article","Immunosurveillance encounters cancer metabolism - Review article","","Tumor cells reprogram nutrient acquisition and metabolic pathways to satisfy energetic, biosynthetic, and redox requirements, while metabolic programs in immune cells support host antitumor immunity and shape leukocyte differentiation and fate. In the tumor microenvironment, metabolic imbalance in immune cells can promote immune evasion and reduce therapeutic effectiveness. Anti-tumor immunity also modulates tumor heterogeneity, aggressiveness, and metabolic reprogramming. This review integrates how metabolic crosstalk affects tumor cell immunogenicity and cancer progression.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/immunosurveillance-encounters-cancer-metabolism-review-article/342551/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/immunosurveillance-encounters-cancer-metabolism-review-article/342551.png","ImageObject",300,407,{"name":92,"@type":93},"Anda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"How do tumor metabolic reprogramming and immune cell metabolism interact during immunosurveillance?","Question",{"text":112,"@type":113},"Tumor cells and immune cells use metabolic pathways that can reinforce or impair immunity. Metabolic deregulation in immune cells within the tumor microenvironment can drive immune evasion and compromise therapies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What roles do metabolic defects play in dysfunctional immune responses against cancer?",{"text":117,"@type":113},"Defects in metabolic cascades can contribute to improper immune responses, and immunosurveillance can further feed back to reinforce these defects.",{"name":119,"@type":110,"acceptedAnswer":120},"Which therapeutic directions does the review highlight?",{"text":121,"@type":113},"It emphasizes ongoing clinical trials and new therapeutic strategies that target cellular metabolism in cancer, aiming to improve antitumor immunity and outcomes.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},342551,1790187117,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962075006959,"https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297","Review Article  \nImmunosurveillance encounters cancer metabolism  \nYu-Ming Chuang1,2,5, Sheue-Fen Tzeng 3,5, Ping-Chih Ho 1,2 ✉ & Chin-Hsien Tsai 3,4 ✉  \nAbstract  \nTumor cells reprogram nutrient acquisition and metabolic pathways to meet their energetic, biosynthetic, and redox demands. Similarly, metabolic processes in immune cells support host immunity against cancer and determine differentiation and fate of leukocytes. Thus, metabolic deregulation and imbalance in immune cells within the tumor microenvironment have been reported to drive immune evasion and to compromise therapeutic outcomes. Interestingly, emerging evidence indicates that anti-tumor immunity could modulate tumor heterogeneity, aggressiveness, and metabolic reprogramming, suggesting that immunosurveillance can instruct cancer progression in multiple dimensions. This review summarizes our current understanding of how metabolic crosstalk within tumors affects immunogenicity of tumor cells and promotes cancer progression. Furthermore, we explain how defects in the metabolic cascade can contribute to developing dysfunctional immune responses against cancers and discuss the contribution of immunosurveillance to these defects as a feedback mechanism. Finally, we highlight ongoing clinical trials and new therapeutic strategies targeting cellular metabolism in cancer.  \nKeywords Immunoediting; Immunometabolism; Cancer Evolution Subject Categories Cancer; Immunology; Metabolism  \n[https://doi.org/10.1038/s44319-023-00038-w](https://doi.org/10.1038/s44319-023-00038-w)  \nReceived 10 February 2023; Revised 2 December 2023; Accepted 12 December 2023  \nPublished online: 12 January 2024  \nIntroduction  \nUnderstanding anti-tumor immunity and immune checkpoints has fostered the development of immunotherapies, such as immune checkpoint blockade (ICB) and, more recently, chimeric antigen receptor T-cells (CAR T-cells) . However, the tumor microenvironment (TME) forms a metabolic barrier due to metabolic deregulations in tumor cells to disarm host anti-tumor immunity and current immunotherapeutic strategies (Ho and Liu, 2016; Liet al, 2019c) . Metabolic dysregulation in tumors has been known for decades and is defined as a hallmark of cancer (Hanahan, 2022) . In the past, those gained metabolic activities were considered to support unconstrained growth and anti-apoptosis in tumor cells.  \nIn addition, metastatic tumor cells with unique metabolic abilities can potentiate their colonization at the secondary site (Altea-Manzano et al, 2020; Faubert et al, 2020; Tasdogan et al, 2020) . Tumor cells have a high metabolic rate, but the tumor microenvironment often lacks proper blood flow and experiences changes in fluid pressure. Thus, it has been speculated that cells within the TME struggle to obtain nutrition and oxygen they need to survive (Heldin et al, 2004) . However, several studies indicate that tumor cells can alter their metabolism to adapt to their environment and to support their bioenergetic needs (Bergers and Fendt, 2021) . Additionally, tumor cells can change their physiological traits, such as metabolism and stemness properties, through interactions with immune and stromal cells to avoid detection by the immune system (Bayik and Lathia, 2021) . Of note, tumorderived metabolites can influence the makeup of metastatic niches and the behavior of T cells by rewiring the epigenetic landscape (Baumann et al, 2022; Chapman et al, 2020) . Therefore, it can be inferred that tumor cells can alter the metabolic state ofthe TME or adapt their metabolism to overcome unfavorable conditions, such as nutrient scarcity and immune surveillance.  \nIn this review, we discuss the effects of bidirectional metabolic crosstalk between tumor cells and infiltrating immune cells on immune suppression and metabolic adaption of cancer cells during immunosurveillance derived from the innate and adaptive arm of the immune system, with a particular focus on T cells, regulatory T cells (Tregs), and natur","cbCaidKrvwdSRI3P","https://ap.wps.com/l/cbCaidKrvwdSRI3P","pdf",3170825,18,"English","# Abstract\n# Introduction\n# Metabolic reprogramming shapes tumorigenesis\n## Intrinsic mutations drive specific nutrient dependencies during cancer progression\n## Oncogenic mutations and tumor suppression reshape metabolic demands","[{\"question\":\"How do tumor metabolic reprogramming and immune cell metabolism interact during immunosurveillance?\",\"answer\":\"Tumor cells and immune cells use metabolic pathways that can reinforce or impair immunity. Metabolic deregulation in immune cells within the tumor microenvironment can drive immune evasion and compromise therapies.\"},{\"question\":\"What roles do metabolic defects play in dysfunctional immune responses against cancer?\",\"answer\":\"Defects in metabolic cascades can contribute to improper immune responses, and immunosurveillance can further feed back to reinforce these defects.\"},{\"question\":\"Which therapeutic directions does the review highlight?\",\"answer\":\"It emphasizes ongoing clinical trials and new therapeutic strategies that target cellular metabolism in cancer, aiming to improve antitumor immunity and outcomes.\"}]","Immunosurveillance encounters cancer metabolism - Review article | PDF",1790047094,45]