[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-333705-105":59,"doc-detail-333705-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","immunomodulatory-and-chemopreventive-effects-of-resveratrol-on-the-digestive-system-cancers-review","Immunomodulatory and Chemopreventive Effects of Resveratrol on the Digestive System Cancers - Review","","Resveratrol (RSV), a grape-derived polyphenol, is reviewed for its immunomodulatory and chemopreventive actions against digestive system cancers. RSV reduces pro-inflammatory cytokine production in peripheral blood mononuclear cells and may suppress cancer initiation, proliferation, neovascularization, and migration. Mechanisms include antioxidant activity, cell-cycle arrest, enzyme modulation, and activation of signaling pathways that can culminate in apoptosis, pyroptosis, and necroptosis observed in vitro. The review highlights the need for future clinical research.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/immunomodulatory-and-chemopreventive-effects-of-resveratrol-on-the-digestive-system-cancers-review/333705/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/immunomodulatory-and-chemopreventive-effects-of-resveratrol-on-the-digestive-system-cancers-review/333705.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What immunomodulatory effect does resveratrol have according to the review?","Question",{"text":112,"@type":113},"Resveratrol reduces the ability of peripheral blood mononuclear cells to produce pro-inflammatory cytokines such as IL-1β, IL-6, IL-1ra, and TNFα, linking immunomodulation with anti-cancer potential.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does resveratrol influence cancer development in digestive system cancers?",{"text":117,"@type":113},"The review describes inhibition of cancer initiation and progression, including effects on proliferation, neovascularization, and migration, supported by antioxidant effects, cell-cycle arrest, enzyme stimulation, and signaling pathway activation.",{"name":119,"@type":110,"acceptedAnswer":120},"What types of cell death are associated with resveratrol in vitro?",{"text":121,"@type":113},"Resveratrol is reported to induce multiple forms of cell death, including apoptosis, pyroptosis, necroptosis, and additional mechanisms observed in vitro.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333705,1790646910,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","ONCOLOGY RESEARCH 2024 32(9): 1389-1399 REVIEW  \nImmunomodulatory and chemopreventive effects of resveratrol on the digestive system cancers  \nMEIR DJALDETTI*  \nLaboratory for Immunology and Hematology Research, Rabin Medical Center, Hasharon Hospital, Petah-Tiqva, the Sackler School of Medicine, Tel-Aviv University, Ramat Aviv, 69978, Israel  \nKey words: Resveratrol (RSV), Chemoprevention, Digestive tract cancers, Immunity, Cell death, Polyphenols  \nAbstract: Resveratrol (RSV), the primary polyphenol found in grapes, has been revealed to have anti-inflammatory properties by reducing the capacity of the peripheral blood mononuclear cells to produce pro-inflammatory cytokines, including IL-1β, IL-6, IL-1ra and TNFα . Considering the close association between chronic inflammation and cancer development, RSV’s immunomodulatory properties are one way by which the polyphenol may inhibit cancer initiation, proliferation, neovascularization, and migration. Resveratrol influences the generation of microtumor environment which is one of the key factors in cancer progress. In addition to immunomodulation, RSV inhibits cancer development by expressing anti-oxidant effects, causing cell cycle arrest, stimulating the function of certain enzymes, and activating cell signaling pathways. The end outcome is one of the various forms of cell death, including apoptosis, pyroptosis, necroptosis, and more, as it has been observed in vitro. RSV has been shown to act against cancer in practically every organ, while its effects on colon cancer have been documented more frequently. It is remarkable that longer-term clinical studies that may have established the potential for this natural substance to serve as a therapeutic adjuvant to traditional anti-cancer medications were not prompted by the encouraging outcomes seen with cancer cells treated with non-toxic doses of resveratrol. The current review aims to assess the recent findings about the immunological and anti-cancer characteristics of RSV, with a particular emphasis on cancers of the  \ndigestive tract, as a challenge for future clinical research that may contribute to the better prognosis of cancer.  \nIntroduction  \nThe history of grape cultivation is estimated to be 6,000 to 8,000 old, based on archeological and seed findings [1] . The dual utilization of grapes as a delicious fruit and as a source for extensive vine production explains their widespread farming and development. Leaving apart the high commercial value of the grapes in the nutritional and vine industry, grapes consumption is associated with beneficial health virtues. Studies have shown that grapes feeding diminishes the risk of cardiovascular and skin diseases, diabetes, neurodegeneration, Alzheimer disease, obesity, and certain types of cancers [2–4] . These effects result from grapes’ high polyphenol content, of which RSV is the most significant. Plants that produced RSV were significant items in the Asian pharmacopeia, according to Venkat et al. [5] .  \n*Address correspondence to: Meir Djaldetti, [meird@clalit.org.il](meird@clalit.org.il)[ ](meird@clalit.org.il)[Received: 17 January 2024](Received: 17 January 2024); [Accepted: 23 May 2024](Accepted: 23 May 2024);  \nPublished: 23 August 2024  \nRSV has demonstrated anti-inflammatory properties by mitigating the harmful effects of reactive oxygen species (ROS), primarily hydrogen peroxide and superoxide radicals [6] . For middle-aged and older people with increased oxidative and anti-inflammatory activity, RSV plays an important role. It was shown that treatment of their peripheral blood mononuclear cells (PBMC) with RSV regulated the production of the pro-inflammatory cytokines IL-6 and TNFα [7] . RSV inhibits the activity of immune recognition receptors (TLR), such as TLR4, which stimulates the inflammatory mediators nuclear factor kappa B (NF-kB) and interferon (IFN) [8] . Given the proven impact of chronic inflammation on the onset and progression of cancer [9, 10] and the immune system’s","cbCaimGM2PBMnaD4","https://ap.wps.com/l/cbCaimGM2PBMnaD4","pdf",899170,11,"English","# Introduction\n# Resveratrol as an Immunomodulator","[{\"question\":\"What immunomodulatory effect does resveratrol have according to the review?\",\"answer\":\"Resveratrol reduces the ability of peripheral blood mononuclear cells to produce pro-inflammatory cytokines such as IL-1β, IL-6, IL-1ra, and TNFα, linking immunomodulation with anti-cancer potential.\"},{\"question\":\"How does resveratrol influence cancer development in digestive system cancers?\",\"answer\":\"The review describes inhibition of cancer initiation and progression, including effects on proliferation, neovascularization, and migration, supported by antioxidant effects, cell-cycle arrest, enzyme stimulation, and signaling pathway activation.\"},{\"question\":\"What types of cell death are associated with resveratrol in vitro?\",\"answer\":\"Resveratrol is reported to induce multiple forms of cell death, including apoptosis, pyroptosis, necroptosis, and additional mechanisms observed in vitro.\"}]","Immunomodulatory and Chemopreventive Effects of Resveratrol on the Digestive System Cancers - Review | PDF",1790003675,28]