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Transcriptomic, genomic, single-cell transcriptomic, methylation, and immune-cell infiltration analyses from The Cancer Genome Atlas were integrated to evaluate aberrant expression, prognostic value, and immune regulation links. P2RY6 was elevated in cancers, predicted poor survival, correlated with CD8+ T-cell abundance, and enabled an inflammation-based prognosis model outperforming TNM staging.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/immunological-role-and-clinical-prognostic-significance-of-p2ry6-in-lung-adenocarcinoma-a-multi-omics-studies-and-single-cell-sequencing-analysis/381782/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/immunological-role-and-clinical-prognostic-significance-of-p2ry6-in-lung-adenocarcinoma-a-multi-omics-studies-and-single-cell-sequencing-analysis/381782.png","ImageObject",300,407,{"name":92,"@type":93},"McGucket","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the primary objective of this study on P2RY6 in LUAD?","Question",{"text":112,"@type":113},"To determine the immunological role and clinical prognostic significance of P2RY6 in lung adenocarcinoma using multi-omics and single-cell sequencing analyses.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was P2RY6 expression and immune-cell involvement assessed?",{"text":117,"@type":113},"The study used TCGA transcriptomic, genomic, single-cell transcriptomic, and methylation data, with immune infiltration quantified by CIBERSORT and correlations with immune checkpoint and immune regulation genes.",{"name":119,"@type":110,"acceptedAnswer":120},"What prognostic value did the authors report for P2RY6-related modeling?",{"text":121,"@type":113},"They developed a P2RY6-related inflammation prediction model for LUAD prognosis with an AUC of 0.83, which performed significantly better than the traditional TNM staging system.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},381782,1790293680,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1236954412713,"https://us-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Wu and Dong  \nWorld Journal of Surgical Oncology (2023) 21:341 [https://doi.org/10.1186/s12957-023-03216-1](https://doi.org/10.1186/s12957-023-03216-1)  \nWorld Journal of Surgical Oncology  \n RESEARCH Open Access  \nImmunological role and clinical prognostic   significance of P2RY6 in lung adenocarcinoma: a multi-omics studies and single-cell sequencing analysis  \nHongWu1* and Xuhui Dong1  \nAbstract  \nBackground There is increasing evidence that recombinant human P2Y purinoceptor 6 (P2RY6) may be involved in inflammatory responses. However, the role of P2RY6 in lung adenocarcinoma (LUAD) remains unknown.  \nMethods We used transcriptomic, genomic, single-cell transcriptomic, and methylation sequencing data from The Cancer Genome Atlas database to analyze the aberrant status and prognostic value of P2RY6 in a variety of tumors. The LUAD single-cell sequencing dataset was used to explore the effect of P2RY6 on the tumor microenvironment. Cell-type identification by estimating relative subsets of RNA transcripts (CIBERSORT) was used to quantify immune cells in the tumor microenvironment. We also analyzed the correlation of P2RY6 with immune checkpointsand immune regulation-related genes. The correlation of between tumor mutation burden (TMB), microsatellite instability (MSI), and P2RY6 expression was also analyzed simultaneously. Tissue microarray and immunohistochemistry were employed to assess the expression of P2RY6 in internal tumor samples.  \nResults Our findings indicate that P2RY6 exhibits significantly higher expression levels in various cancer tissues, particularly in LUAD. High expression of P2RY6 was closely associated with a poor prognosis for patients, and it plays a role in regulating immune-related pathways, such as cytokine-cytokine receptor interaction. Notably, P2RY6 expression is closely linked to the abundance of CD8 + T cells. Furthermore, we have developed a P2RY6-related inflammation prediction model that demonstrates promising results in predicting the prognosis of LUAD patients, with an AUC (area under the curve) value of 0.83. This performance is significantly better than the traditional TNM staging system. Through single-cell transcriptome sequencing analysis, we observed that high P2RY6 expression is associated with increased intercellular communication. Additionally, pathway enrichment analysis revealed that P2RY6 influences antigen presentation and processing pathways within the LUAD microenvironment.  \nConclusions This study suggests that P2RY6 would be a new target for immunotherapy in LUAD. Keywords P2RY6, Lung adenocarcinoma, Immunotherapy, Pan-cancer, Clinical prognostic  \n*Correspondence:  \nHongWu [wuhong19842021@Hotmail.com](wuhong19842021@Hotmail.com)  \n1 Department of Pneumology, Yiwu Central Hospital, Zhejiang, China  \nIntroduction  \nLung cancer is currently the most prevalent form of malignancy worldwide, with the highest incidence and mortality rates [1]. It can be classified into two subtypes: small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLC accounts for 85% of all cases  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licens","cbCaii6jcWPPreMq","https://ap.wps.com/l/cbCaii6jcWPPreMq","pdf",8277014,17,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"What is the primary objective of this study on P2RY6 in LUAD?\",\"answer\":\"To determine the immunological role and clinical prognostic significance of P2RY6 in lung adenocarcinoma using multi-omics and single-cell sequencing analyses.\"},{\"question\":\"How was P2RY6 expression and immune-cell involvement assessed?\",\"answer\":\"The study used TCGA transcriptomic, genomic, single-cell transcriptomic, and methylation data, with immune infiltration quantified by CIBERSORT and correlations with immune checkpoint and immune regulation genes.\"},{\"question\":\"What prognostic value did the authors report for P2RY6-related modeling?\",\"answer\":\"They developed a P2RY6-related inflammation prediction model for LUAD prognosis with an AUC of 0.83, which performed significantly better than the traditional TNM staging system.\"}]","Immunological role and clinical prognostic significance of P2RY6 in lung adenocarcinoma - a multi-omics studies and single-cell sequencing analysis | PDF",1790247020,43]