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The program highlights molecular and cellular mechanisms behind immune dysfunction and inflammaging, including macrophage senescence and pro-inflammatory phenotypes that contribute to chronic inflammation and fibrosis across aging and metabolic disease. 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It also emphasizes age-related chronic inflammation, termed inflammaging.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which cellular mechanisms are highlighted as drivers of immune dysfunction?",{"text":117,"@type":113},"It highlights molecular and cellular mechanisms underlying immune dysfunction and inflammaging, including macrophages that can enter cellular senescence and adopt pro-inflammatory phenotypes.",{"name":119,"@type":110,"acceptedAnswer":120},"How does metabolism relate to immune aging in the session?",{"text":121,"@type":113},"The session explores cross-talk between metabolism and immune processes during aging, linking metabolic and immune changes to inflammation and dysfunction.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},423665,1790794536,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81,"preview_page_count":4},962084931830,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","244 Innovation in Aging, 2025, Vol. 9, No. S2  \ncells during aging, and how this impacts tissue inflammation during aging. Dr. Duygu Ucar (The Jackson Laboratory) will present systems-level and single-cell genomic approaches that reveal molecular signatures of immune aging, including how biological sex, infection history, and epigenetic remodeling shape immune responsesand vaccine efficacy across aging. Dr. Seokjo Kang (Cedars-Sinai Medical Center) will conclude by examining molecular mechanisms controlling microglial aging, including sex-specific differences in microglial gene expression, metabolism, and function, and how these changes contribute to neuroinflammation and cognitive decline. Together, these talks will explore cutting-edge approaches and recent discoveries in molecular and cellular biology, metabolism, and computational fields to enhance our understanding of immune aging and its systemic effects on the aging process. The session will also showcase emerging therapeutic strategies aimed at rejuvenating the immune system and extending health span.  \nSESSION 2277 (BIOLOGICAL SCIENCES  \nINVITED SYMPOSIUM)   \nAbstract citation ID: igaf122.817  \nIMMUNOLOGICAL ASPECTS OF AGING  \nChair: Anthony Covarubbias  \nThe immune system undergoes significant changes and dysregulation during aging, leading to immune cell exhaustion and senescence, impaired tissue homeostasis, age-related chronic inflammation (inflammaging), and decreased pathogen immunity.This session will focus on the immunological aspects of aging and highlight new insights into the molecular and cellular mechanisms that drive immune dysfunction and inflammaging. Dr.Anthony J. Covarrubias (UCLA) will chair this session and also discuss recent discoveries that macrophages can undergo cellular senescence, adopting pro-inflammatory phenotypes that promote chronic inflammation and fibrosis in aging and metabolic disease. Dr. Emily Goldberg (UCSF) will explore the cross-talk between metabolism and immune","cbCaiaMIYwTma5ug","https://ap.wps.com/l/cbCaiaMIYwTma5ug","pdf",264251,"English","# Immunological Aspects of Aging\n## Immune dysregulation during aging\n## Molecular and cellular mechanisms of immune dysfunction\n## Macrophage senescence and pro-inflammatory phenotypes\n## Metabolism–immune cross-talk\n## Systemic effects and therapeutic strategies","[{\"question\":\"What immune changes occur during aging in this symposium?\",\"answer\":\"The symposium describes immune exhaustion and senescence, dysregulated immune function, impaired tissue homeostasis, and reduced pathogen immunity. It also emphasizes age-related chronic inflammation, termed inflammaging.\"},{\"question\":\"Which cellular mechanisms are highlighted as drivers of immune dysfunction?\",\"answer\":\"It highlights molecular and cellular mechanisms underlying immune dysfunction and inflammaging, including macrophages that can enter cellular senescence and adopt pro-inflammatory phenotypes.\"},{\"question\":\"How does metabolism relate to immune aging in the session?\",\"answer\":\"The session explores cross-talk between metabolism and immune processes during aging, linking metabolic and immune changes to inflammation and dysfunction.\"}]","Immunological Aspects of Aging - Invited Symposium | PDF",1790631634]