[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-330864-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-330864-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","immunohistochemical-detection-of-mnsod-in-colon-adenocarcinoma-patients-clinical-application","Immunohistochemical detection of MnSOD in colon adenocarcinoma patients - clinical application","","Colon adenocarcinoma (COAD) is a major digestive-system malignancy with markedly different outcomes between early and advanced diagnoses, making metastasis-related risk stratification clinically urgent. The study evaluates immunohistochemical expression of manganese superoxide dismutase (MnSOD) in Polish COAD patients and correlates staining results with clinicopathological factors and overall survival. Paraffin-embedded adenocarcinoma tissues were examined, and MnSOD reactivity showed limited association with clinicopathological variables. Multivariate analysis indicated tumor differentiation grade and MnSOD expression in non-cancerous tissues as independent risk factors for worse survival, while conclusions report no link between high cancer-tissue MnSOD levels and key prognostic endpoints.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/immunohistochemical-detection-of-mnsod-in-colon-adenocarcinoma-patients-clinical-application/330864/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/immunohistochemical-detection-of-mnsod-in-colon-adenocarcinoma-patients-clinical-application/330864.png","ImageObject",300,407,{"name":42,"@type":43},"Maeve","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",6,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the main aim of the study?","Question",{"text":63,"@type":64},"To investigate immunohistochemical expression of MnSOD in colon adenocarcinoma patients and assess its prognostic significance by correlating it with clinicopathological factors and overall survival.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were MnSOD levels measured?",{"text":68,"@type":64},"Paraffin-embedded adenocarcinoma samples were evaluated immunohistochemically for MnSOD protein expression.",{"name":70,"@type":61,"acceptedAnswer":71},"Did MnSOD expression correlate with clinicopathological factors and 5-year overall survival?",{"text":72,"@type":64},"The study reports that MnSOD immunohistochemical reactivity was not correlated with clinicopathological factors, and high MnSOD levels in cancerous tissue were not associated with malignancy-related factors and 5-year overall survival.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},330864,1790500299,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":110,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":117},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","Original paper  \nImmunohistochemical detection of MnSOD in colon adenocarcinoma patients – clinical application  \nJerzy Z. Piecuch1, Marek Kucharzewski2, Grzegorz Wyrobiec3, Marlena Brzozowa-Zasada3  \n1 Department of General and Bariatric Surgery and Emergency Medicine in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland  \n2 Faculty of Health Sciences, Jan Dlugosz University of Czestochowa, Czestochowa, Poland  \n3 Department of Histology and Cell Pathology in Zabrze, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Poland  \nGastroenterology Rev 2024; 19 (2): 186–193 DOI: [https://doi.org/10.5114/pg.2024.139238](https://doi.org/10.5114/pg.2024.139238)  \nKey words: antioxidant enzyme, MnSOD, colon adenocarcinoma, oxidative stress.  \nAddress for correspondence: Dr Marlena Brzozowa-Zasada, Department of Histology and Cell Pathology, Faculty of Medical Sciences  \nin Zabrze, Medical University of Silesia in Katowice, Poland, phone: +48 32 2722842, [e-mail: marlena.brzozowa@op.pl](e-mail: marlena.brzozowa@op.pl)  \nAbstract  \nIntroduction: Colon adenocarcinoma (COAD) is one of the most frequently identified cancers of the digestive system. It is worth noting that the 5-year survival rates for patients diagnosed early are approximately 90%, whereas for patients with advanced diagnosis it is only 10% . It may indicate that metastasis is a critical cause of death for cancer patients.  \nAim: The current study investigated the immunohistochemical expression of MnSOD in individuals living in Poland, who were diagnosed as colon adenocarcinoma patients, to assess its prognostic significance by correlating its expression with the clinicopathological factors and overall survival (OS) .  \nMaterial and methods: Paraffin-embedded adenocarcinoma samples were assessed immunohistochemically for MnSOD protein. The relationship between MnSOD immunoexpression and clinicopathological factors including the 5-year overall survival (OS) were evaluated.  \nResults: Immunohistochemical expression of MnSOD protein was detected in colon adenocarcinoma samples and non-pathological samples of colon tissues. As demonstrated, the level of the MnSOD immunohistochemical reactivity was not correlated with clinicopathological factors. A multivariate analysis demonstrated that the grade of tumour differentiation and MnSOD immunoexpression in healthy tissues were independent risk factors for worse survival of patients.  \nConclusions: The high level of MnSOD immunoexpression in cancerous tissue was not associated with malignancy-related clinicopathological factors and 5-year overall survival of patients.  \nIntroduction  \nColon adenocarcinoma (COAD) is one of the most commonly diagnosed cancers of the gastrointestinal system. It is thought that more than 2.2 million new cases will be diagnosed and 1.1 million deaths will occur because of COAD by 2030. Unfortunately, despite adequate surgical therapies and chemotherapies, the 5-year survival rate of COAD patients is still poor. It is worth noting that the 5-year survival rate for patients diagnosed early is approximately 90%, whereas for patients with advanced diagnosis it is only 10% . This may indicate that metastasis is a critical cause of death for cancer patients [1–3] . Hence, there is an urgent need to identify novel prognostic biomarkers associated with metastasis, which can identify the high-risk patients  \nand facilitate the timely application of appropriate individual treatments for COAD patients.  \nIt has been widely reported that mitochondria area known source of intracellular reactive oxygen species (ROS) . Under physiological conditions they are constantly generated as by-products of aerobic metabolism in the mitochondria. During mitochondrial respiration, the tricarboxylic acid (TCA) cycle produces components with reducing properties, acting as a source for electrons. Electron transfer between mitochondrial electron transport comple","cbCaihhZVgk6o2kF","https://ap.wps.com/l/cbCaihhZVgk6o2kF","pdf",298204,"English","# Abstract\n## Introduction\n## Aim\n## Material and methods\n## Results\n## Conclusions\n# Introduction\n# Aim","[{\"question\":\"What was the main aim of the study?\",\"answer\":\"To investigate immunohistochemical expression of MnSOD in colon adenocarcinoma patients and assess its prognostic significance by correlating it with clinicopathological factors and overall survival.\"},{\"question\":\"How were MnSOD levels measured?\",\"answer\":\"Paraffin-embedded adenocarcinoma samples were evaluated immunohistochemically for MnSOD protein expression.\"},{\"question\":\"Did MnSOD expression correlate with clinicopathological factors and 5-year overall survival?\",\"answer\":\"The study reports that MnSOD immunohistochemical reactivity was not correlated with clinicopathological factors, and high MnSOD levels in cancerous tissue were not associated with malignancy-related factors and 5-year overall survival.\"}]","Immunohistochemical detection of MnSOD in colon adenocarcinoma patients - clinical application | PDF",1789990552]