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PJS polyps were compared with familial adenomatous polyposis (FAP) and sporadic polyps using pathology and gene expression profiling, alongside paracancerous tissues or colon cancers. Results show PJS polyps resemble cancer immune microenvironments, with elevated CD80 expression and myeloid accumulation, especially MDSCs.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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the study objective regarding PJS polyps?","Question",{"text":63,"@type":64},"The study assessed the suitability of PJS polyps for immunotherapy and aimed to identify shared immune-evasion mechanisms between PJS polyps and cancers.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were immune cells and immune checkpoint genes evaluated?",{"text":68,"@type":64},"Polyps were analyzed using pathological and gene expression profiling to characterize infiltrating immune cells and measure the expression of immune checkpoint genes.",{"name":70,"@type":61,"acceptedAnswer":71},"What key immune features were found in PJS polyps?",{"text":72,"@type":64},"PJS polyps showed a closer resemblance to cancer tissues’ immune microenvironment, including higher CD80 expression and increased accumulation of myeloid cells, particularly 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ARTICLE  \nImmune profiling of premalignant lesions in patients with Peutz‐Jeghers syndrome  \nZhongyue Liu1,2 | Boda Wu3 | Xiaoliu Shi4,5 | Junfeng Zhou6 | Hui Huang4 | Zhihong Li 1,7 | Mei Yang1,7   \n1Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China  \n2Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China  \n3Department of Gastroenterology, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China  \n4Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China  \n5Department of Gastroenterology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China  \n6Endoscopic Medical Center, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China  \n7Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China  \nCorrespondence  \nMei Yang and Zhihong Li, The Second Xiangya Hospital, Central South University, 139 Middle Renmin Road, Changsha, Hunan 410011, China.  \nEmail: [yangmei23@csu.edu.cn](yangmei23@csu.edu.cn) and [lizhihong@csu.edu.cn](lizhihong@csu.edu.cn)  \nFunding information  \nNational Natural Science Foundation of China, Grant/Award Number: 82172500; Natural Science Foundation of Hunan Province, Grant/ Award Number: 2021JJ30971  \nAbstract  \nBackground: Peutz‐Jeghers syndrome (PJS), is a rare autosomal dominant hereditary disease characterized by an elevated risk of various cancers. Serine/Threonine Kinase 11 (STK11) gene is a major tumor suppressor crucial for immune evasion with and beyond tumorigenic cells. It has garnered increasing attention in the realm of oncology treatment, particularly in the context of immunotherapy development. Objective: This study aimed to assess the suitability of polyps obtained from individuals with PJS, resulting from germline STK11 deficiency, for immunotherapy. Additionally, we seek to identify potential shared mechanisms related to immune evasion between PJS polyps and cancers. To achieve this, we examined PJS polyps alongside familial adenomatous polyposis (FAP) and sporadic polyps.  \nMethods: Polyps were compared among themselves and with either the paracancerous tissues or colon cancers. Pathological and gene expression profiling approaches were employed to characterize infiltrating immune cells and assess the expression of immune checkpoint genes.  \nResults: Our findings revealed that PJS polyps exhibited a closer resemblance to cancer tissues than other polyps in terms of their immune microenvironment. Notably, PJS polyps displayed heightened expression of the immune checkpoint gene CD80 and an accumulation of myeloid cells, particularly myeloid‐derived suppressor cells (MDSCs).  \nConclusion: The findings suggest an immunobiological foundation for the increased cancer susceptibility in PJS patients, paving the way for potential immune therapy applications in this population. Furthermore, utilizing PJS as a model may facilitate the exploration of immune evasion mechanisms, benefiting both PJS and cancer patients.  \nKEYWORDS  \nCD80, colorectal cancer, CRC, genetic, immunogenicity, MDSC, PJS, polyposis, premalignant lesion, STK11  \n\n| Zhongyue Liu and Boda Wu contributed equally. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.\u003Cbr>© 2024 The Author(s). United European Gastroenterology Journal published by Wiley Periodicals LLC on behalf of United European Gastroenterology. |\n\n338 - United European Gastroenterol J. 2025;13:338–348. wi[leyonlinelibrary.com/journal/ueg2](leyonlinelibrary.com/journal/ueg2","cbCais72SzZSiyno","https://ap.wps.com/l/cbCais72SzZSiyno","pdf",3121191,11,"English","# Abstract\n## Background\n## Objective\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What was the study objective regarding PJS polyps?\",\"answer\":\"The study assessed the suitability of PJS polyps for immunotherapy and aimed to identify shared immune-evasion mechanisms between PJS polyps and cancers.\"},{\"question\":\"How were immune cells and immune checkpoint genes evaluated?\",\"answer\":\"Polyps were analyzed using pathological and gene expression profiling to characterize infiltrating immune cells and measure the expression of immune checkpoint genes.\"},{\"question\":\"What key immune features were found in PJS polyps?\",\"answer\":\"PJS polyps showed a closer resemblance to cancer tissues’ immune microenvironment, including higher CD80 expression and increased accumulation of myeloid cells, particularly MDSCs.\"}]","Immune profiling of premalignant lesions in patients with Peutz-Jeghers syndrome | PDF",1790000336,28]