[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-372711-105":59,"doc-detail-372711-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","igfbp2-alteration-contributes-to-prostate-cancer-progression-by-modulating-prostate-stroma-activation","IGFBP2 alteration contributes to prostate cancer progression by modulating prostate stroma activation","","Insulin-like growth factor binding protein-2 (IGFBP2) is a secreted regulator of IGF activity and is highly expressed in prostate cancer, yet its molecular roles in tumor progression remain unclear. This study analyzes IGFBP2 expression in prostate cancer cells and stromal fibroblasts and evaluates functional consequences of IGFBP2 knockdown or supplementation. Reduced stromal IGFBP2 increases reactive stroma activation and promotes pro-tumor cytokine secretion via TGF-β upregulation, thereby enhancing malignant progression.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/igfbp2-alteration-contributes-to-prostate-cancer-progression-by-modulating-prostate-stroma-activation/372711/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/igfbp2-alteration-contributes-to-prostate-cancer-progression-by-modulating-prostate-stroma-activation/372711.png","ImageObject",300,407,{"name":92,"@type":93},"Aldword","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does IGFBP2 play in prostate cancer progression according to the study?","Question",{"text":112,"@type":113},"IGFBP2 is implicated as a regulatory factor in activating the prostate stromal microenvironment. The study links altered stromal IGFBP2 to more aggressive prostate cancer progression through cytokine changes mediated by TGF-β.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Do IGFBP2 treatment with siRNAs or recombinant protein directly affect tumor cell growth and invasiveness?",{"text":117,"@type":113},"No. Tumor cell growth and invasiveness were not directly affected by IGFBP2 siRNAs or recombinant IGFBP2 in the reported results.",{"name":119,"@type":110,"acceptedAnswer":120},"How does decreased stromal IGFBP2 influence the prostate stroma and tumor-supporting signaling?",{"text":121,"@type":113},"Lower IGFBP2 expression increases prostate stromal fibroblast activation and elevates pro-tumorigenic cytokines, including IL-6, IL-8, IP10, and CCL5. This effect is attributed to upregulation of TGF-β.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},372711,1790528825,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},2336478940917,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Huang et al. Cell Communication and Signaling (2025) 23:408  \n[https://doi.org/10.1186/s12964-025-02414-6](https://doi.org/10.1186/s12964-025-02414-6)  \nCell Communication and Signaling  \nBRIEF REPORT Open Access  \nIGFBP2 alteration contributes to prostate cancer progression by modulating prostate stroma activation  \nMingguo Huang 1,2*, Shintaro Narita 1, Hiromi Sato 1, Yuya Sekine 1, Mizuki Kobayashi 1, Soki Kashima 1, Ryohei Yamamoto 1, Atsushi Koizumi 1, Taketoshi Nara 1, Kazuyuki Numakura 1, Mitsuru Saito 1, Hiroshi Nanjo 1, Takayuki Ikezoe2 and Tomonori Habuchi 1  \nAbstract  \nBackground Insulin-like growth factor (IGF) binding protein-2 (IGFBP2) is a secretory protein that modulate the activity of IGFs. It is highly expressed in various cancers such as prostate cancer (PCa), in which it may play a controversial role in tumor progression, however, the molecular mechanisms of IGFBP2 in PCa progression remain unclear.  \nMethods In this study, we examined the expression pattern and role of IGFBP2 in PCa cells and the stroma during prostate tumor cell progression.  \nResults IGFBP2 was highly expressed in LNCaP cells and prostate stromal fibroblasts (PrSC) and was mainly secreted by PrSCs. Tumor cell growth and invasiveness were not directly affected by treatment with IGFBP2 siRNAs (siIGFBP2) or recombinant IGFBP2 (rIGFBP2) . However, decreased expression of IGFBP2 significantly increased PrSC activation and the secretion of pro-tumorigenic cytokines IL-6, IL-8, IP10, and CCL5 through upregulation ofTGF-β, which subsequently enhanced prostate tumor cell progression. Clinically, low expression of stromal IGFBP2 was associated with a high reactive prostate stroma, advanced PCa progression, and increased IGFBP2 levels in the serum. Conclusion Here, we provide mechanistic evidence that IGFBP2 act as a critical regulatory factor in the activation of prostate stromal microenvironment and contributes to aggressive PCa progression.  \nKeywords Insulin-like growth factor binding protein-2, IGFBP2, Prostate stromal cells, Prostate cancer  \n*Correspondence:  \nMingguo Huang  \n[huangmg0319@yahoo.co.jp](huangmg0319@yahoo.co.jp)  \n1Department of Urology, and Department of Clinical Pathology, Akita 11 University Graduate School of Medicine, 1-1-1 Hondo, Akita  \n010-8543, Japan  \n2Department of Hematology, Fukushima Medical University, Fukushima, Japan  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creati](http://creati)[vecommons.org/l](vecommons.org/l)icenses/by-nc-nd/4.0/.  \nHuang et al. Cell Communication and Signaling (2025) 23:408  \nIntroduction  \nProstate cancer (PCa) is one of the most common cancers and a leading cause of cancer-related deaths in the United States and Japan [1, 2]. Prostate stromal fibroblasts (PrSC) are a critical component of the prostate stroma and have emerged as a key factor in the formation of the reactive PCa microenvironment and tumor progression through crosstalk with adjacent cancer cells and the secretion of proinflammatory cytokines or growth factors [3]. Alpha smooth m","cbCair0lxsvSYCEA","https://ap.wps.com/l/cbCair0lxsvSYCEA","pdf",1695718,"English","# Abstract\n# Introduction\n## IGFBP2 and reactive prostate stroma\n# Materials and methods","[{\"question\":\"What role does IGFBP2 play in prostate cancer progression according to the study?\",\"answer\":\"IGFBP2 is implicated as a regulatory factor in activating the prostate stromal microenvironment. The study links altered stromal IGFBP2 to more aggressive prostate cancer progression through cytokine changes mediated by TGF-β.\"},{\"question\":\"Do IGFBP2 treatment with siRNAs or recombinant protein directly affect tumor cell growth and invasiveness?\",\"answer\":\"No. Tumor cell growth and invasiveness were not directly affected by IGFBP2 siRNAs or recombinant IGFBP2 in the reported results.\"},{\"question\":\"How does decreased stromal IGFBP2 influence the prostate stroma and tumor-supporting signaling?\",\"answer\":\"Lower IGFBP2 expression increases prostate stromal fibroblast activation and elevates pro-tumorigenic cytokines, including IL-6, IL-8, IP10, and CCL5. This effect is attributed to upregulation of TGF-β.\"}]","IGFBP2 alteration contributes to prostate cancer progression by modulating prostate stroma activation | PDF",1790195187,25]