[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-413327-105":59,"doc-detail-413327-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","identification-of-prothrombin-belgrade-variant-in-a-mexican-american-family-with-recurrent-deep-vein-thrombosis","Identification of Prothrombin Belgrade Variant in a Mexican-American Family with Recurrent Deep Vein Thrombosis","","A rare prothrombin variant (c.1787G>A, p.Arg596Gln), also called the prothrombin Belgrade variant, is linked to increased thrombosis predisposition through resistance to antithrombin. In this case report, the first described heterozygous occurrence in a Mexican-American family is presented, alongside recurrent early-onset venous thromboembolism despite negative standard hypercoagulable studies. Findings suggest that comprehensive genetic thrombophilia testing should be considered in recurrent VTE with strong personal and/or family history but negative routine evaluations, especially in understudied ethnic backgrounds.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/identification-of-prothrombin-belgrade-variant-in-a-mexican-american-family-with-recurrent-deep-vein-thrombosis/413327/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/identification-of-prothrombin-belgrade-variant-in-a-mexican-american-family-with-recurrent-deep-vein-thrombosis/413327.png","ImageObject",300,407,{"name":92,"@type":93},"mieayamfan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the prothrombin Belgrade variant discussed in the report?","Question",{"text":112,"@type":113},"It is a rare F2 gene variant (c.1787G>A, p.Arg596Gln) associated with increased thrombosis risk through antithrombin resistance.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What were the standard hypercoagulable study results in the affected individuals?",{"text":117,"@type":113},"The affected individuals had negative results on standard hypercoagulable testing despite a history of early-onset and recurrent venous thromboembolism.",{"name":119,"@type":110,"acceptedAnswer":120},"Why do the authors recommend comprehensive genetic thrombophilia testing?",{"text":121,"@type":113},"They suggest it can identify prothrombin variants linked to antithrombin resistance, particularly when routine studies are negative but personal and/or family history strongly suggests inherited thrombophilia.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},413327,1790812528,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52,"preview_page_count":4},962090893677,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","THIEME  \nArticle published online: 2025-12-22  \nCase Report  \n1  \nIdentification of Prothrombin Belgrade Variant in a Mexican–American Family with Recurrent Deep Vein Thrombosis  \nÉmile Moura Coelho da Silva1,2 Natalie Montanez 1 Miguel Escobar 1  \n1 Gulf States Hemophilia and Thrombophilia Center, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States  \n2 Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, United States  \nTH Open 2025;9:a27665989 .  \nAddress for correspondence Émile Moura Coelho da Silva, MS, 7000 Fannin Street, Suite 750, Houston, TX 77007, United States  \n(e-mail: [emilemouraa@gmail.com](emilemouraa@gmail.com)).  \nAbstract  \nKeywords  \n► F2 gene variant  \n► prothrombin  \n► thrombophilia  \n► venous thromboembolism  \nA rare prothrombin variant (c.1787G >A, p.Arg596Gln), also known as the prothrombin Belgrade variant, has been associated with an increased predisposition to thrombosis through resistance to antithrombin. This variant has been previously reported in individuals from Serbia, Japan, China, and India. In this case report, we described the first reported case of heterozygosity for the prothrombin Belgrade variant in a Mexican–American family. Affected individuals had negative results on standard hypercoagulable studies; however, they exhibited a history of early-onset and recurrent venous thromboembolism (VTE) . Although rare, the prothrombin Belgrade variant—and other prothrombin variants associated with antithrombin resistance—may be underrecognized in patients with recurrent thrombotic events, particularly among individuals from ethnic backgrounds not previously associated with this variant. These findings support the consideration of comprehensive genetic thrombophilia testing, including full sequencing of the prothrombin gene, in patients with negative standard hypercoagulable studies but a strong personal and/or family history of VTE.  \nIntroduction  \nVenous thromboembolism (VTE) affects approximately 1 in 1,000 individuals annually.1 While VTE is multifactorial in origin, a hereditary cause should be suspected in patients with early-onset VTE (typically before age 40 or 50), a strong family history, recurrent episodes, or thrombosis in unusual locations, such as the central nervous system.2 Standard hereditary thrombophilia evaluation includes testing for protein S, protein C, antithrombin deficiency, and the factor V Leiden and prothrombin G20210A variants.3 However, additional genetic variants associated with thrombosis risk have been identified, including several variants in theprothrombin (F2 ) gene that confer antithrombin resis-  \nreceived  \nAugust 20, 2025 accepted after revision December 5, 2025  \nDOI [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.1055/a-2766-5989.](10.1055/a-2766-5989.)[ ](10.1055/a-2766-5989.)[ISSN](ISSN 2512-9465.)[ 2512-9465.](ISSN 2512-9465.)  \ntance.4–6 One such variant is the prothrombin Belgrade (c. 1787G>A, p.Arg596Gln), previously reported in individuals from Serbia, Japan, China, and India.4,7–9 We report the first known case of this variant in a Mexican–American family with a history of recurrent VTE.  \nThis study was conducted in accordance with the principles of the Declaration of Helsinki. As the work consists of case reports and does not constitute systematic research on human subjects, it was exempt from Institutional Review Board review, and individual informed consent was formally waived. Nevertheless, informed consent was obtained from two of the three participants; the third participant could not be reached despite multiple attempts.  \n© 2025 . The Author(s) .  \nThis is an open access article published by Thieme under the terms of the Creative Commons Attribution License, permitting unrestricted use, distribution, and reproduction so long as the original work is properly cited.([https://creativecommons.org/licens","cbCaibhPcZNR4eHq","https://ap.wps.com/l/cbCaibhPcZNR4eHq","pdf",203897,"English","# Abstract\n# Introduction\n## Venous thromboembolism and hereditary risk assessment\n# Case Summaries\n## Case 1","[{\"question\":\"What is the prothrombin Belgrade variant discussed in the report?\",\"answer\":\"It is a rare F2 gene variant (c.1787G\\u003eA, p.Arg596Gln) associated with increased thrombosis risk through antithrombin resistance.\"},{\"question\":\"What were the standard hypercoagulable study results in the affected individuals?\",\"answer\":\"The affected individuals had negative results on standard hypercoagulable testing despite a history of early-onset and recurrent venous thromboembolism.\"},{\"question\":\"Why do the authors recommend comprehensive genetic thrombophilia testing?\",\"answer\":\"They suggest it can identify prothrombin variants linked to antithrombin resistance, particularly when routine studies are negative but personal and/or family history strongly suggests inherited thrombophilia.\"}]","Identification of Prothrombin Belgrade Variant in a Mexican-American Family with Recurrent Deep Vein Thrombosis | PDF",1790594458]