[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332767-105":59,"doc-detail-332767-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","identification-of-fibrosis-associated-biomarkers-in-heart-failure-and-human-cancers","Identification of fibrosis-associated biomarkers in heart failure and human cancers","","Heart failure and cancer share common risk factors and pathophysiological pathways, particularly fibrosis, making biomarker discovery and therapeutic target identification essential. RNA sequencing from heart failure patients was used to screen 12 fibrosis-related genes. Public datasets validated dysregulation patterns, while functional enrichment analyses clarified involved biological processes. Gene expression profiles and prognostic relevance were evaluated across multiple cancer types, including relationships with cancer-associated fibroblasts.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/identification-of-fibrosis-associated-biomarkers-in-heart-failure-and-human-cancers/332767/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/identification-of-fibrosis-associated-biomarkers-in-heart-failure-and-human-cancers/332767.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are fibrosis-related biomarkers important for both heart failure and cancers?","Question",{"text":112,"@type":113},"Because heart failure and cancer share common risk factors and fibrotic pathophysiological mechanisms, identifying biomarkers and therapeutic targets can guide treatment in both conditions.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were fibrosis-associated genes identified and validated?",{"text":117,"@type":113},"RNA sequencing data from heart failure patients were analyzed to identify 12 genes linked to myocardial fibrosis, followed by validation using public datasets and functional enrichment analyses.",{"name":119,"@type":110,"acceptedAnswer":120},"Which genes were highlighted as dysregulated and potentially prognostic across cancers?",{"text":121,"@type":113},"FMOD, POSTN, LTBP2, COL1A1, COL8A1, ASPN, and HBB showed significant dysregulation in heart failure tissues and were implicated across multiple cancer types with associations to prognosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332767,1791420336,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Hou et al. Journal of Translational Medicine (2024) 22:1042  \n[https://doi.org/10.1186/s12967-024-05759-7](https://doi.org/10.1186/s12967-024-05759-7)  \nJournal of Translational Medicine  \nRESEARCH Open Access  \nIdentification of fibrosis-associated biomarkers in heart failure and human cancers  \nCan Hou2†, Junyu Huo2†, Si Yan2, Fei Sun 1* and Xiaoyu Yang2*  \nAbstract  \nBackground Heart failure (HF) and cancer share common risk factors and pathophysiological mechanisms, including fibrosis. Identifying biomarkers and therapeutic targets for both conditions is crucial.  \nMaterials and methods RNA sequencing data from HF patients were analyzed to identify 12 genes associated with myocardial fibrosis. Validation was performed using public datasets, and functional enrichment analyses were conducted. Gene expression patterns and prognostic value in various cancers were assessed.  \nResults Fibromodulin (FMOD), Periostin (POSTN), Latent Transforming Growth Factor Beta Binding Protein 2 (LTBP2), Collagen Type I Alpha 1 Chain (COL1A1), Collagen Type VIII Alpha 1 Chain (COL8A1), Asporin (ASPN), and Hemoglobin Subunit Beta (HBB) showed significant dysregulation in heart failure tissues and were implicated in multiple cancer types. Pan-cancer analysis revealed associations between these genes and prognosis. Correlations with cancerassociated fibroblasts were also observed.  \nConclusion FMOD, POSTN, LTBP2, COL1A1, COL8A1, ASPN, and HBB are potential biomarkers for HF and cancer with fibrotic microenvironments. Targeting fibrosis may offer novel therapeutic approaches. Further validation and mechanistic studies are needed. This study contributes to understanding HF and cancer at the molecular level and suggests personalized treatment strategies.  \nKeywords Heart failure, Cancer-associated fibroblasts, Bioinformatics analysis, Cardiovascular diseases  \n†Can Hou and Junyu Huo contributed equally to this  \nwork. Corresponding Author: Fei Sun, Email: [sunfei@njmu.edu](sunfei@njmu.edu).  \ncn; Xiaoyu Yang, [Email: jsczyxy@163.com](Email: jsczyxy@163.com)  \n*Correspondence: Fei Sun [sunfei@njmu.edu.cn](sunfei@njmu.edu.cn)[ ](sunfei@njmu.edu.cn)Xiaoyu Yang [jsczyxy@163.com](jsczyxy@163.com)  \n1Department of Radiotherapy, The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University, Changzhou,  \nJiangsu Province 213000, China  \n2Department of Cardiovascular Medicine, The First People’s Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province 213000, China  \nIntroduction  \nHeart failure (HF) is a global health issue that continues to be a significant contributor to mortality, morbidity, and diminished quality of life. HF is characterized by cardiac remodeling, typically resulting from conditions such as hypertension, myocardial infarction (MI), myocarditis, or heart valve diseases. Alcoholic cardiomyopathy, a consequence of chronic alcohol consumption leading to chamber dilatation, myofibrillar disorganization, interstitial fibrosis, and diminished myocardial contractility, presents as an additional cause of HF [1]. Moreover, Lipopolysaccharide (LPS) from Gram-negative bacteria and the apelinergic system play crucial roles in HF [2, 3].  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the artic","cbCaiiFmoSj1jrFK","https://ap.wps.com/l/cbCaiiFmoSj1jrFK","pdf",4809618,16,"English","# Abstract\n# Background\n# Materials and methods\n# Results\n# Conclusion\n# Keywords\n# Introduction","[{\"question\":\"Why are fibrosis-related biomarkers important for both heart failure and cancers?\",\"answer\":\"Because heart failure and cancer share common risk factors and fibrotic pathophysiological mechanisms, identifying biomarkers and therapeutic targets can guide treatment in both conditions.\"},{\"question\":\"How were fibrosis-associated genes identified and validated?\",\"answer\":\"RNA sequencing data from heart failure patients were analyzed to identify 12 genes linked to myocardial fibrosis, followed by validation using public datasets and functional enrichment analyses.\"},{\"question\":\"Which genes were highlighted as dysregulated and potentially prognostic across cancers?\",\"answer\":\"FMOD, POSTN, LTBP2, COL1A1, COL8A1, ASPN, and HBB showed significant dysregulation in heart failure tissues and were implicated across multiple cancer types with associations to prognosis.\"}]","Identification of fibrosis-associated biomarkers in heart failure and human cancers | PDF",1789999429]