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Public datasets and cell line analyses assessed FANCG expression, alongside MTT and migration assays to evaluate cellular function. Co-expressed genes and enrichment analyses explored biological relevance, while qPCR quantified hub gene expression. FANCG upregulation aligned with aggressive clinical features and poorer survival.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/identification-of-fancg-as-a-prognostic-factor-for-prostate-cancer/366105/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/identification-of-fancg-as-a-prognostic-factor-for-prostate-cancer/366105.png","ImageObject",300,407,{"name":92,"@type":93},"Rizky","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the purpose of studying FANCG in prostate cancer?","Question",{"text":112,"@type":113},"To determine the role of the FANCG gene in prostate cancer and evaluate FANCG as a prognostic biomarker.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was FANCG expression measured in the study?",{"text":117,"@type":113},"FANCG expression was assessed using publicly available datasets and cell lines, with quantitative real-time PCR used to quantify hub gene expression.",{"name":119,"@type":110,"acceptedAnswer":120},"What relationship did FANCG expression show with clinical outcomes?",{"text":121,"@type":113},"Higher FANCG mRNA expression correlated with higher serum PSA, advanced pathological stage, higher Gleason score, and shorter overall and disease-free survival.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},366105,1790625393,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Gao et al.  \nEuropean Journal of Medical Research (2025) 30:602 [https://doi.org/10.1186/s40001-025-02877-w](https://doi.org/10.1186/s40001-025-02877-w)  \nEuropean Journal of Medical Research  \n RESEARCH Open Access  \nIdentification of FANCG as a prognostic factor for prostate cancer  \nWenlong Gao1†, Peng Liu2†, Han Xinyue1, Yuanjie Niu2* and Wu Yi1*  \nAbstract  \nBackground To ascertain role of the fanconi anemia complementation group G (FANCG) gene in prostate cancer (PCa) and the suitability of the FANCG gene as a prognostic biomarker for PCa.  \nMethods We assessed the expression of FANCG using an analysis of publicly available data sets and cell lines. Physiological functioning of the cells was evaluated through MTT assays and migration assays. Co-expressed genes and enrichment analysis were conducted to probe the biological significance of FANCG in PCa. Quantitative real-time polymerase chain reaction (qPCR) was utilized to detect the expression levels of hub genes (MCM7, MCM5, POLD1, POLA2, LIG1) associated with FANCG.  \nResults We observed a significant upregulation of FANCG expression in PCa patients and cell lines. Furthermore, immunohistochemical analysis demonstrated markedly higher FANCG protein expression in PCa tissues compared to non-cancerous PCa tissues. Downregulation of FANCG significantly inhibited cell proliferation and migration potential. Evaluation of FANCG-related hub genes (MCM7, MCM5, POLD1, POLA2, and LIG1) revealed their close association with cell cycle-related signaling pathways. Upregulation of FANCG mRNA expression in PCa tissues significantly correlated with high serum PSA levels, advanced pathological stage, high Gleason score, shorter overall survival time, and shorter disease-free survival time.  \nConclusions This study suggests that FANCG likely plays a pivotal role in PCa progression. In addition, increased FANCG expression may serve as an indicator of poor disease-free survival and an adverse prognosis for PCa patients. Keywords Prostate cancer, Fanconi anemia complementation group G, Prognostic factor, Bioinformatics  \nBackground  \nProstate cancer (PCa) ranks among the most prevalent malignancies affecting men on a global scale, with an estimated 1.4 million new cases annually [1]. The high incidence of prostate cancer, along with issues related  \n†Wenlong Gao and Peng Liu contributed equally to this paper.  \n*Correspondence:  \nYuanjie Niu [yuanjieniuo1@outlook.com](yuanjieniuo1@outlook.com)[ ](yuanjieniuo1@outlook.com)WuYi  \n[wuy6250@163.com](wuy6250@163.com)  \n1 Department of Urology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China  \n2 Nankai University, Tianjin 300211, China  \nto overtesting and suboptimal treatment outcomes, places a significant burden on patients and society as a whole [2, 3]. While the precise etiology of prostate cancer remains elusive, its development is understood to result from intricate interactions involving genetic, environmental, and lifestyle factors [1]. Recent advances in high-throughput sequencing technology have shed light on the genetic heterogeneity of tumors, revealing highrisk genetic factors associated with various solid tumors, including prostate cancer.  \nNonetheless, the mechanisms underlying tumorigenesis and progression have yet to be fully elucidated. The intricate genetic heterogeneity of prostate cancer presents diagnostic and therapeutic challenges. Therefore, the analysis of sequencing data to identify effective tumor  \n© The Author(s) 2025, corrected publication 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Comm","cbCaiaPgEkR7oTV6","https://ap.wps.com/l/cbCaiaPgEkR7oTV6","pdf",2159389,11,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusions\n# Background","[{\"question\":\"What was the purpose of studying FANCG in prostate cancer?\",\"answer\":\"To determine the role of the FANCG gene in prostate cancer and evaluate FANCG as a prognostic biomarker.\"},{\"question\":\"How was FANCG expression measured in the study?\",\"answer\":\"FANCG expression was assessed using publicly available datasets and cell lines, with quantitative real-time PCR used to quantify hub gene expression.\"},{\"question\":\"What relationship did FANCG expression show with clinical outcomes?\",\"answer\":\"Higher FANCG mRNA expression correlated with higher serum PSA, advanced pathological stage, higher Gleason score, and shorter overall and disease-free survival.\"}]","Identification of FANCG as a prognostic factor for prostate cancer | PDF",1790163839,28]