[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330256-105":59,"doc-detail-330256-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","hypoxia-promotes-metastasis-by-relieving-mir-598-3p-restricted-glycolysis-in-gastric-cancer","Hypoxia promotes metastasis by relieving miR-598-3p-restricted glycolysis in gastric cancer","","The activation of glycolysis, particularly when cancer reprograms energy metabolism, is increasingly viewed as a key cancer feature. Yet how glycolysis becomes enhanced in metastatic gastric cancer cells under normal oxygen remains unclear. MicroRNAs shape malignant behaviors in gastric cancer, but their roles in hypoxia-driven metabolic switching and the ensuing metastasis are incompletely defined. Hypoxia-induced miR-598-3p downregulation increases RMP and IGF1r, driving glycolysis and promoting metastasis. Restoring miR-598-3p or treating with R406 suppresses metastasis in vitro and in vivo. miR-598-3p depletion shifts glucose metabolism from oxidative phosphorylation to glycolysis, worsening malignancy, suggesting a therapeutic target in miR-598-3p-high gastric cancers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hypoxia-promotes-metastasis-by-relieving-mir-598-3p-restricted-glycolysis-in-gastric-cancer/330256/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hypoxia-promotes-metastasis-by-relieving-mir-598-3p-restricted-glycolysis-in-gastric-cancer/330256.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What role does hypoxia play in metastatic gastric cancer cells?","Question",{"text":112,"@type":113},"Hypoxia creates a microenvironment that supports cancer progression by promoting metabolic adaptation, including a shift toward glycolysis that benefits metastatic behavior.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is miR-598-3p connected to glycolysis under hypoxic conditions?",{"text":117,"@type":113},"Hypoxia downregulates miR-598-3p, which mechanistically leads to upregulation of RMP and IGF1r, thereby promoting glycolysis.",{"name":119,"@type":110,"acceptedAnswer":120},"What evidence shows that miR-598-3p restoration or R406 suppresses metastasis?",{"text":121,"@type":113},"Overexpressing miR-598-3p or using R406 suppresses metastasis of gastric cancer cells in both in vitro experiments and in vivo models.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330256,1790190677,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","Zhou et al. Journal of Translational Medicine (2024) 22:283  \n[https://doi.org/10.1186/s12967-024-04957-7](https://doi.org/10.1186/s12967-024-04957-7)  \nJournal of Translational Medicine  \n RESEARCH Open Access  \nHypoxia promotes metastasis by relieving miR-598-3p-restricted glycolysis in gastric  \ncancer  \nWei Zhou1†, Mengyuan Tang1,2†, Dan He1, Yi Shen1, Ziwei Huang1, Wenxin Xia1, Zhiyun Wu1, Wenxiang Wei3, Hui Zheng1,4, Qi Wang5*, Weifeng Shi1* and Jingting Jiang5*  \nAbstract  \nThe activation of glycolysis, particularly in the context of reprogrammed energy metabolism, is increasingly recognized as a significant characteristic of cancer. However, the precise mechanisms by which glycolysis is promoted in metastatic gastric cancer cells under normal oxygen conditions remain poorly understood. MicroRNAs (miRNAs) play a crucial role in the development of malignant phenotypes in gastric cancer. Nevertheless, our understanding of the specific involvement of miRNAs in hypoxia-induced metabolic shifting and the subsequent metastatic processes is limited. Hypoxia-induced downregulation of miR-598-3p mechanistically leads to the upregulation of RMP and IGF1r, thereby promoting glycolysis. Either overexpression of miR-598-3p or R406 treatment effectively suppresses the metastasis of gastric cancer cells both in vitro and in vivo. Collectively, the depletion of miR-598-3p alters glucose metabolism from oxidative phosphorylation to glycolysis, thereby exacerbating the malignancy of gastric cancer cells. The present findings indicate a potential target for the development of therapeutics against gastric cancers with increased miR-598-3p expression.  \nKeywords Glucose metabolism, Metastasis, Hypoxia, microRNAs, Gastric cancer  \n†Wei Zhou and Mengyuan Tang contributed equally to this study. Qi Wang, Weifeng Shi and Jingting Jiang both corresponding authors.  \n*Correspondence: Qi Wang [wangqi88@suda.edu.cn](wangqi88@suda.edu.cn)[ ](wangqi88@suda.edu.cn)Weifeng Shi [swf67113@163.com](swf67113@163.com)[ ](swf67113@163.com)Jingting Jiang [jiangjingting@suda.edu.cn](jiangjingting@suda.edu.cn)  \n1 Department of Clinical Laboratory, The Third Affiliated Hospital of Soochow University, ChangZhou 213003, Jiangsu, China  \n2 Department of Immunology, Soochow University, SuZhou 215004, Jiangsu, China  \n3 Department of Cell Biology, Soochow University, SuZhou 215004, Jiangsu, China  \n4 Institutes of Biology and Medical Science (IBMS), Soochow University, SuZhou 215004, Jiangsu, China  \n5 Department of Biological Treatment, The Third Affiliated Hospital of Soochow University, ChangZhou 213003, Jiangsu, China  \nIntroduction  \nGastric cancer and other solid tumors have the common characteristics of fast growth and metastasis. However, the rapid growth of gastric cancer often outpaces the development of functional blood vessels, and there is frequently insufficient O2 supplementation in the regions of cancer [1–3] . Therefore, tumor cells exist in a hypoxic microenvironment, which is a fundamental solid tumor microenvironment feature. The ability of cancer cell to adjust their glucose metabolism from oxidative phosphorylation to glycolysis is in response to the hypoxic microenvironment, a metabolic adaptation that confers significant benefits such as enhanced energy production and heightened activity of intermediates in various metabolic pathways. The continuous production of acidic lactate alters the tumor microenvironment, therefore impairing tumor immune responses  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, u","cbCaivsXkuu8adfn","https://ap.wps.com/l/cbCaivsXkuu8adfn","pdf",2941386,16,"English","# Abstract\n# Keywords\n# Introduction\n## Hypoxia and metabolic adaptation in gastric cancer\n## Glycolytic gene upregulation under hypoxia\n## Oncogenic cooperation and mechanistic motivation","[{\"question\":\"What role does hypoxia play in metastatic gastric cancer cells?\",\"answer\":\"Hypoxia creates a microenvironment that supports cancer progression by promoting metabolic adaptation, including a shift toward glycolysis that benefits metastatic behavior.\"},{\"question\":\"How is miR-598-3p connected to glycolysis under hypoxic conditions?\",\"answer\":\"Hypoxia downregulates miR-598-3p, which mechanistically leads to upregulation of RMP and IGF1r, thereby promoting glycolysis.\"},{\"question\":\"What evidence shows that miR-598-3p restoration or R406 suppresses metastasis?\",\"answer\":\"Overexpressing miR-598-3p or using R406 suppresses metastasis of gastric cancer cells in both in vitro experiments and in vivo models.\"}]","Hypoxia promotes metastasis by relieving miR-598-3p-restricted glycolysis in gastric cancer | PDF",1789987910]