[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-326726-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-326726-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","hypothyroidism-and-hyperthyroidism-related-to-gynecologic-cancers-a-nationwide-population-based-cohort-study","Hypothyroidism and hyperthyroidism related to gynecologic cancers - a nationwide population-based cohort study","","Nationwide retrospective cohort research evaluates risks of hyperthyroidism and hypothyroidism in relation to site-specific gynecologic cancers among women in Taiwan. Using the Taiwan National Health Insurance Research Database, the study follows participants from January 1, 2000 to December 31, 2018 and estimates incidence and hazard ratios with Cox proportional hazards models. Results indicate hyperthyroidism is associated with a reduced gynecologic cancer risk, while hypothyroidism shows a slightly increased risk, suggesting an association with thyroid function level.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/hypothyroidism-and-hyperthyroidism-related-to-gynecologic-cancers-a-nationwide-population-based-cohort-study/326726/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/hypothyroidism-and-hyperthyroidism-related-to-gynecologic-cancers-a-nationwide-population-based-cohort-study/326726.png","ImageObject",300,407,{"name":42,"@type":43},"Logic","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main purpose of the nationwide cohort study?","Question",{"text":63,"@type":64},"To assess the risks of hyperthyroidism and hypothyroidism related to gynecologic cancers in women.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which gynecologic cancer sites were examined?",{"text":68,"@type":64},"Endometrial cancer, uterine corpus cancer, and ovarian cancer.",{"name":70,"@type":61,"acceptedAnswer":71},"How did thyroid dysfunction relate to gynecologic cancer risk?",{"text":72,"@type":64},"Women with hyperthyroidism showed a significantly reduced risk, whereas women with hypothyroidism had a slightly increased risk.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},326726,1790109519,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":123,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nHypothyroidism and hyperthyroidism related to gynecologic cancers:  \na nationwide population‑based cohort study  \nJohn Hang Leung1, Shyh‑Yau Wang2, Henry W. C. Leung 3*, Teng‑Shun Yu4 & Agnes L. F. Chan 5*  \nThe purpose of this study was to assess the risks of hyperthyroidism and hypothyroidism related to gynecological cancers. Population‑based retrospective cohort study. We conducted a cohort study using the Taiwan National Health Insurance Research Database to explore hyperthyroidism and hypothyroidism associated with site‑specific gynecologic cancers in women from January 1, 2000 to December 31, 2018. The examined gynecologic cancers included endometrial (EC), uterine corpus cancer (UC), and ovarian cancer (OC). The incidence and hazard ratios were quantified using Cox proportional hazards models. The incidence of developing gynecological (Gyn) cancers in the hyperthyroid and hypothyroid women was 0.29 and 0.44 per 1000 person‑years, which was 0.86 fold lower and 1.13 fold higher than that in the comparison cohort (p \u003C 0.001) . Compared with patients aged 20–40 years, patients in older age groups had a lower and higher risk of developing Gyn cancers (for hyperthyroid, 40–65 years: adjusted hazard ratio (aHR) = 0.82; > 65 years: aHR = 0.94; for hypothyroid, adjusted hazard ratio (aHR) = 1.26; > 65 years: aHR = 1.38) . Compared with the non‑ hypothyroid women and non‑hyperthyroid women beyond 6 years of follow‑up, hypothyroid and hyperthyroid women showed decreased risk of Gyn cancers. Medication treatment for hyperthyroid and hypothyroid disease did not showed significant association in subgroup analyses (aHR = 0.99 and 0.80, respectively) . Our results show that women with hyperthyroidism have a significantly reduced risk of gynecological cancers, whereas women with hypothyroidism have a slightly increased risk of gynecological cancers suggesting an association between thyroid function level and risk of gynecological cancers.  \nGynecological cancers are a major public health problem worldwide, with an estimated 1.3 million new cases diagnosed and over 6.7 million deaths in 20201. In Taiwan, the three highest incidence rates in 2019 were endometrial cancer (corpus uteri) ovarian cancer and cervix uteri. The crude incidence rate in 2020 were 25.51 per 100,000 (endometrial cancer), 15.34 per 100,000 (ovarian cancer) and 12.08 per 100,000 (cervix uteri cancer)2. The incidence and mortality rates are continuously increasing and tend to be younger. Therefore Taiwan’s National Health Service recommends that gynecological cancer cases should be detected early and selected appropriate cancer treatment strategies to prolong survival2.  \nEndometrial cancer (EC) is one of the most common gynecological cancer and is highly related to the endocrine system. Epidemiological studies reported that risk factors for EC may relate to metabolic syndrome, obesity,  \n1Department of Obstetrics and Gynecology, Ditmanson Medical Foundation Chia-Yi Christian Hospital, No. 539, Zhongxiao Road, East Dist., Chiayi 60002, Taiwan. 2Department of Radiology, An-Nan Hospital, China Medical University, No. 66, Sec. 2, Changhe Rd., Annan Dist., Tainan, Taiwan. 3Department of Radiation Oncology, An-Nan Hospital, China Medical University, No. 66, Sec. 2, Changhe Rd., Annan Dist., Tainan, Taiwan. 4Management Office for Health Data, Clinical Trial Research Center, China Medical University Hospital, No. 2, Yude Road, North District, Taichung 40447, Taiwan. 5Department of Pharmacy, An-Nan Hospital, China Medical University, No. 66, Sec. 2, Changhe Rd., Annan Dist., Tainan 709, Taiwan.* email: [070506@tool.caaumed.org.tw](070506@tool.caaumed.org.tw); [bigeyefong@gmail.com](bigeyefong@gmail.com);  \n[agnes.lf@gmail.com](agnes.lf@gmail.com)  \n[www. nature.com/scientificreports/](www. nature.com/scientificreports/)  \ndiabetes, hypertension, younger age at menarche, late age at menopause, infer","cbCaiiRZIS3ERk7w","https://ap.wps.com/l/cbCaiiRZIS3ERk7w","pdf",1050943,"English","# Study purpose and design\n## Data source and cohort period\n## Cancer sites analyzed\n## Statistical analysis\n## Key findings and interpretation","[{\"question\":\"What is the main purpose of the nationwide cohort study?\",\"answer\":\"To assess the risks of hyperthyroidism and hypothyroidism related to gynecologic cancers in women.\"},{\"question\":\"Which gynecologic cancer sites were examined?\",\"answer\":\"Endometrial cancer, uterine corpus cancer, and ovarian cancer.\"},{\"question\":\"How did thyroid dysfunction relate to gynecologic cancer risk?\",\"answer\":\"Women with hyperthyroidism showed a significantly reduced risk, whereas women with hypothyroidism had a slightly increased risk.\"}]","Hypothyroidism and hyperthyroidism related to gynecologic cancers - a nationwide population-based cohort study | PDF",1789975201,25]