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While clinical benefits are reported, persistent concern remains that HBOT may affect cancer progression. This retrospective study evaluated safety and clinical outcomes in patients with active or previously treated solid tumors undergoing at least five HBOT sessions, tracking recurrence, metastasis, and mortality.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hyperbaric-oxygen-therapy-for-managing-cancer-treatment-complications-a-safety-evaluation/371352/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hyperbaric-oxygen-therapy-for-managing-cancer-treatment-complications-a-safety-evaluation/371352.png","ImageObject",300,407,{"name":92,"@type":93},"Rowan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What patient population was included in the safety evaluation of HBOT?","Question",{"text":112,"@type":113},"The study retrospectively analyzed patients with solid tumors who underwent at least five HBOT sessions, including individuals with active or previously treated cancers.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was HBOT safety assessed in relation to cancer outcomes?",{"text":117,"@type":113},"HBOT-related complications were monitored throughout treatment, and clinical outcomes including recurrence, metastasis, and mortality were recorded during follow-up.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find regarding tumor progression, recurrence, and metastasis?",{"text":121,"@type":113},"No HBOT-related complications were observed, and no significant evidence indicated that HBOT contributed to tumor progression, recurrence, or metastasis in the studied cohort.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},371352,1790535195,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},1099514067415,"https://ap-avatar.wpscdn.com/avatar/100002539d78ffe74a7?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779092875211072502","Article  \nHyperbaric Oxygen Therapy for Managing Cancer Treatment Complications: A Safety Evaluation  \nKubra Canarslan Demir 1, Ahmet Ugur Avci 2, Munire Kubra Ozgok Kangal 1, Berrin Ceylan 2, Selcen Yusra Abayli 1, Ismail Ozler 3 and Kerim Bora Yilmaz 3,4, *  \nAcademic Editor: Enrico Mario Camporesi  \nReceived: 28 December 2024  \nRevised: 13 February 2025  \nAccepted: 19 February 2025  \nPublished: 22 February 2025  \nCitation: Canarslan Demir, K.; Avci, A.U.; Ozgok Kangal, M.K.; Ceylan, B.; Abayli, S.Y.; Ozler, I.; Yilmaz, K.B. Hyperbaric Oxygen Therapy for Managing Cancer Treatment Complications: A Safety Evaluation.  \nMedicina 2025, 61, 385. [https://](https://)[ ](https://)[doi.org/10.3390/medicina61030385](doi.org/10.3390/medicina61030385)  \n[Copyright:](Copyright:) © 2025 by the authors. Published by MDPI on behalf of the Lithuanian University of Health Sciences. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Department of Undersea and Hyperbaric Medicine, Gulhane Research and Training Hospital, University of Health Sciences, 06010 Ankara, Turkey; [drcanarslan@hotmail.com](drcanarslan@hotmail.com) (K.C.D.);  \n[kubra_ozgk@hotmail.com](kubra_ozgk@hotmail.com) (M.K.O.K.)  \n2 Department of Aerospace Medicine, Gulhane Research and Training Hospital, University of Health Sciences, 06010 Ankara, Turkey  \n3 Department of General Surgery, Gulhane Research and Training Hospital, University of Health Sciences, 06010 Ankara, Turkey  \n4 Department of Medical and Surgical Research, Institute of Health Sciences, Hacettepe University, 06010 Ankara, Turkey  \n* Correspondence: [kerimbora.yilmaz@sbu.edu.tr; Tel./Fax: +90-(505)-2543897](kerimbora.yilmaz@sbu.edu.tr; Tel./Fax: +90-(505)-2543897)  \nAbstract: Background and Objectives: Hyperbaric oxygen therapy (HBOT) has shown promise in managing complications due to cancer treatments, particularly those related to radiotherapy and surgery. Despite its clinical benefits, concerns persist regarding its potential to influence cancer progression. This study aimed to evaluate the safety and clinical outcomes of HBOT in patients with active or previously treated solid tumors. Methods: A retrospective analysis was conducted on patients with solid tumors who underwent at least five HBOT sessions. Comprehensive data, including patient demographics, cancer type, total number of HBOT sessions, imaging findings, and clinical outcomes (recurrence, metastasis, and mortality), were collected. Descriptive statistics and the relationship between the number of HBOT sessions and long-term cancer outcomes were analyzed. Results: This study included 45 patients (median age: 64 years; 60% male) who received a median of 27 HBOT sessions. At initiation, 27.9% of the patients were classified as cured, 53.5% were in remission, and 18.6% had active cancer. Over a median follow-up period of 783 days, 8.7% experienced recurrence, 2.7% had persistent active cancer, and 59.5% had no recurrence. No HBOT-related complications were observed during the course of HBOT. Statistical analyses revealed no significant correlations between the number of HBOT sessions and metastasis (p = 0.213) or mortality (p = 0.881) . Conclusions: HBOT appears to be a safe and effective adjunctive therapy for managing complications in patients with solid tumors. No evidence was found to suggest HBOT contributes to tumor progression, recurrence, or metastasis. Future prospective studies with larger cohorts are needed to confirm these results and further evaluate the therapeutic role of HBOT in oncology.  \nKeywords: cancer; hyperbaric oxygen therapy; metastasis; recurrence; safety; tumor progression  \n1. Introduction  \nCancer is the second leading cause of death globally, following cardiovascular ","cbCaidhfjrhPRSst","https://ap.wps.com/l/cbCaidhfjrhPRSst","pdf",713587,12,"English","# Abstract\n## Introduction\n## Methods and Analysis\n## Results\n## Conclusions","[{\"question\":\"What patient population was included in the safety evaluation of HBOT?\",\"answer\":\"The study retrospectively analyzed patients with solid tumors who underwent at least five HBOT sessions, including individuals with active or previously treated cancers.\"},{\"question\":\"How was HBOT safety assessed in relation to cancer outcomes?\",\"answer\":\"HBOT-related complications were monitored throughout treatment, and clinical outcomes including recurrence, metastasis, and mortality were recorded during follow-up.\"},{\"question\":\"What did the study find regarding tumor progression, recurrence, and metastasis?\",\"answer\":\"No HBOT-related complications were observed, and no significant evidence indicated that HBOT contributed to tumor progression, recurrence, or metastasis in the studied cohort.\"}]","Hyperbaric Oxygen Therapy for Managing Cancer Treatment Complications - A Safety Evaluation | PDF",1790191873]