[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-147679-105":59,"doc-detail-147679-en":123},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":116,"head_meta":118,"extra_data":120,"updated_unix":122},105,"en","hybrid-catalysis-as-the-next-challenge-in-biorefineries-concept-and-examples","Hybrid catalysis as the next challenge in biorefineries - concept and examples","","Hybrid catalysis, a direct combination of biocatalysis and chemocatalysis, offers innovative pathways for biorefineries by merging the strengths of both technologies instead of using them sequentially. Sugars can thereby serve as major carbon resources for catalytic fuels and chemicals. Two conceptual hybrid-catalysis routes are proposed to overcome constraints from the enzymatic glucose isomerase equilibrium between glucose and fructose, a key limitation when targeting HMF, based on complexation/transport and hybrid isomerization with cofactor regeneration.",{"@graph":69,"@context":115},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hybrid-catalysis-as-the-next-challenge-in-biorefineries-concept-and-examples/147679/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hybrid-catalysis-as-the-next-challenge-in-biorefineries-concept-and-examples/147679.png","ImageObject",300,407,{"name":92,"@type":93},"Mali","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-08-26",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",15,{"@type":107,"mainEntity":108},"FAQPage",[109],{"name":110,"@type":111,"acceptedAnswer":112},"What are the two conceptual pathways proposed to overcome this limitation?","Question",{"text":113,"@type":114},"One pathway uses a complexation/transport strategy combining glucose isomerase with a fructose-to-HMF dehydration chemocatalyst in a multiphasic scheme. The other pathway converts glucose to sorbitol by hydrogenation and then enzymatically to fructose with in situ cofactor regeneration using an organometallic complex.","Answer","https://schema.org",{"og:url":83,"og:type":117,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":119,"canonical":83},"index,follow",{"doc_id":121,"site_id":62},147679,1787768319,{"code":4,"msg":5,"data":124},{"doc_id":121,"user_id":125,"nickname":92,"user_avatar":126,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":127,"file_id":128,"file_url":129,"file_type":130,"file_size":131,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":132,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":133,"faqs":134,"seo_title":135,"seo_description":67,"update_tm":122,"read_time":24,"preview_page_count":4},2336475104362,"https://ap-avatar.wpscdn.com/avatar/22000c4c46a41b752dd?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786595829695023868","Hybrid catalysis as the next challenge in biorefineries: concept and examples  \nFranck Dumeignil,a,* Alexandra Gimbernat,b Marie Guehl,a,c Mickaël Capron,a Nicolas Lopes Ferreira,d Renato Froidevaux,b,* Jean-Sébastien Girardon,a Pascal Dhulster,b Damien Delcroixc,*  \naUniv. Lille, CNRS, Centrale Lille, ENSCL, Univ. Artois, UMR 8181-UCCS-Unité de Catalyse et Chimie du Solide, F- 59000 Lille, France  \nbUniv. Lille, INRA, ISA, Univ. Artois, Univ. Littoral Côte d'Opale, EA 7394-ICV-Institut Charles Viollette, F-59000 Lille, France  \ncIFP Energies Nouvelles, Rond-point de l’échangeur de Solaize, BP 3, 69360 Solaize, France dIFP Energies Nouvelles, 1 et 4 Avenue de Bois-Préau, 92852 Rueil Malmaison, France  \n*Corresponding authors: +33(0)[20.43.65.61](20.43.65.61), franck.dumeignil@univ-[lille1.fr](lille1.fr), Renato.Froidevaux@univ-[lille1.fr](lille1.fr), [damien.delcroix@ifpen.fr](damien.delcroix@ifpen.fr)  \nAbstract: Hybrid catalysis, a direct combination of biocatalysis and chemocatalysis could yield innovative solutions in the field of biorefineries by straightforwardly merging the advantages of both technologies, rather than sequentially carrying them out. Further, sugars could become a major carbon resource for the catalytic production of fuels and chemicals. In this context, we propose two new conceptual pathways involving hybrid catalysis to overcome limitations resulting from the enzymatic glucose isomerase thermodynamic equilibrium between glucose and fructose, which is a key step when subsequently targeting HMF as a product. These concepts are based on a complexation/transport strategy and a hybrid isomerization, respectively.  \nKeywords: Hybrid Catalysis, Biorefineries, 5-hydroxymethylfurfural, glucose, fructose, sorbitol, cofactor.  \n1. Introduction  \nA new generation of smart catalysts must be developed for biomass upgrading in biorefineries. 1,2 In a conventional approach, biotechnologies and chemocatalysis are sequentially processed. However, recently, successful one-pot transformations have been realized, simultaneously taking advantage of both technologies, under the concept of the so-called ‘hybrid catalysis’.3,4  \nFigure 1. Hybrid catalysis process applied to the transformation of glucose to 5-HMF.  \nFor example, 5-hydroxymethylfurfural (HMF) is a platform molecule derived from glucose through fructose as a key intermediate. To overcome the thermodynamic enzymatic equilibrium between glucose and fructose, which limits efficiency, we propose two strategies based on hybrid catalysis:5 (1) Simultaneous  \nimplementation of glucose isomerase and of fructose to HMF dehydration chemocatalyst in a multiphasic way involving fructose complexation and transport6 (Figure 1) and (2) a route through sorbitol avoiding enzymatic isomerization, readily obtained by glucose hydrogenation in which sorbitol is further enzymatically converted to fructose with an in situ cofactor regeneration using an organometallic complex7 (Figure 2) .  \nFigure 2. Principle of cofactor regeneration by an organometallic complex in the enzymatic reaction of conversion of sorbitol to  \nfructose.  \n2. Results and perspectives  \nOne-pot processes that combine bio- and chemocatalysis provide attractive routes to convert biosourced substrates to valuable products. Herein are presented two concepts for efficient HMF production from glucose involving hybrid catalysis with different methodological approaches. Both combinations are relatively simple to achieve and the first results validate the proof of concepts in both cases: (1) The limitations resulting from the enzymatic glucose isomerase thermodynamic equilibrium between glucose and fructose has been actually overcome with a glucose conversion of 70%, while it is limited to 46%, without fructose transport; (2) Concerning the valorisation via sorbitol, we demonstrated the chemical compatibility between sorbitol dehydrogenase and an organometallic complex used for the cofactor regeneration and ca. 2 cofacto","cbCaicifskxB3E1j","https://ap.wps.com/l/cbCaicifskxB3E1j","pdf",193172,"English","# Introduction\n## Hybrid catalysis concept for biomass upgrading\n## Strategies to produce HMF from glucose\n# Results and perspectives\n## Proof-of-concept outcomes and limitations\n## Scope for other biomass valorization reactions","[{\"question\":\"What are the two conceptual pathways proposed to overcome this limitation?\",\"answer\":\"One pathway uses a complexation/transport strategy combining glucose isomerase with a fructose-to-HMF dehydration chemocatalyst in a multiphasic scheme. The other pathway converts glucose to sorbitol by hydrogenation and then enzymatically to fructose with in situ cofactor regeneration using an organometallic complex.\"}]","Hybrid catalysis as the next challenge in biorefineries - concept and examples | PDF"]