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It outlines the complications, which can include seizures, coma, stroke, and renal failure. The document elaborates on two main types: Shiga-like toxin-associated HUS (typical HUS or aHUS) and atypical HUS (aHUS). For typical HUS, it explains the mechanism involving Shiga-like toxins binding to glomerular endothelial cells, leading to endothelial activation, thrombosis, and acute renal failure in 55-70% of cases, with a 70-85% recovery rate. Diagnostic markers such as PT, PTT, D-dimer, fibrinogen, and FDP levels are mentioned, along with the limited effectiveness of stool cultures for E. coli and Shigella, and the potential for DNA synthesis inhibitors to increase toxin production. For aHUS, the document highlights a dysfunctional complement cascade leading to complement deposition on endothelial cells, endothelial activation, and thrombosis. This form carries a higher mortality, with 25% dying during the acute phase. Treatment strategies discussed include plasma exchange, steroids, antiplatelet agents, fibrinolytics, IVIG, high-dose steroids, and advanced therapies like Eculizumab and Revulizumab which inhibit complement-mediated thrombotic microangiopathy. Plasma exchange is noted as being more common in adults without diarrhea. Supportive care is emphasized, focusing on fluid and electrolyte balance, azotemia control, optimized nutrition, and brain imaging.",{"@graph":69,"@context":105},[70,84],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hus-complications-and-treatment/26625/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hus-complications-and-treatment/26625.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-18","2026-05-08",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction","https://schema.org",{"og:url":107,"og:type":108,"og:title":65,"og:site_name":95,"og:description":67},"https://docshare.wps.com/document/hus-complications-and-treatment/26625","article",{"robots":110,"canonical":107},"index,follow",{"doc_id":112,"site_id":62},26625,1778199153,{"code":4,"msg":5,"data":115},{"doc_id":112,"user_id":116,"nickname":92,"user_avatar":117,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":66,"file_id":118,"file_url":119,"file_type":120,"file_size":121,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":122,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":66,"faqs":66,"seo_title":123,"seo_description":67,"update_tm":113,"read_time":81},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","cbCaisr8YXZgF7fV","https://ap.wps.com/l/cbCaisr8YXZgF7fV","pdf",125254,"English","HUS Complications and Treatment | PDF"]