[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-26624-105":3,"detail-sidebar-cat-0-en-105":64,"doc-detail-26624-en":114},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":56,"head_meta":59,"extra_data":61,"updated_unix":63},105,"en","hus-625490ef3f9b414daac58227289013df","HUS","","This document provides a detailed breakdown of Hemolytic Uremic Syndrome (HUS) and atypical Hemolytic Uremic Syndrome (aHUS), differentiating between pediatric and adult presentations. In children, HUS is often associated with Shiga toxin-producing E. coli and presents with diarrhoea, generally leading to a good prognosis. Treatment involves supportive care, renal replacement therapy, plasma exchange, monoclonal antibodies like Eculizumab and Ravulizumab, and high-dose corticosteroids. For adults, aHUS is characterized by a bad prognosis and lack of diarrhoea, stemming from complement-mediated damage to the endothelium. The complement system initiates deposition of C3, attracting macrophages, neutrophils, and platelets, which collectively damage the endothelium and blood vessels, leading to shearing, formation of schistocytes, hemolytic anemia, thrombocytopenia, consumption of C3, and ultimately renal failure. The document outlines the diagnostic workup (Ix) and management (Mx) strategies for both conditions, emphasizing the critical role of complement inhibitors in aHUS.",{"@graph":14,"@context":55},[15,34],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/hus-625490ef3f9b414daac58227289013df/26624/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/hus-625490ef3f9b414daac58227289013df/26624.png","ImageObject",300,407,{"name":42,"@type":43},"Ezra","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-18","2026-05-08",true,{"@type":52,"interactionType":53,"userInteractionCount":22},"InteractionCounter",{"@type":54},"ViewAction","https://schema.org",{"og:url":57,"og:type":58,"og:title":10,"og:site_name":45,"og:description":12},"https://docshare.wps.com/document/hus-625490ef3f9b414daac58227289013df/26624","article",{"robots":60,"canonical":57},"index,follow",{"doc_id":62,"site_id":7},26624,1778199149,{"code":4,"msg":65,"data":66},"success",[67,71,75,79,84,89,93,98,103,106,110],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":68,"show_sort_weight":69,"slug":70},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":72,"show_sort_weight":73,"slug":74},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":76,"show_sort_weight":77,"slug":78},"Exam",70,"exam",{"id":80,"doc_module":4,"doc_module_name":25,"category_name":81,"show_sort_weight":82,"slug":83},5,"Comic",60,"comic",{"id":85,"doc_module":4,"doc_module_name":25,"category_name":86,"show_sort_weight":87,"slug":88},6,"Technology",50,"technology",{"id":90,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":91,"slug":92},7,40,"healthcare",{"id":94,"doc_module":4,"doc_module_name":25,"category_name":95,"show_sort_weight":96,"slug":97},8,"Research & Report",30,"research-report",{"id":99,"doc_module":4,"doc_module_name":25,"category_name":100,"show_sort_weight":101,"slug":102},9,"Religion & Spirituality",20,"religion-spirituality",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":104,"show_sort_weight":101,"slug":105},"World Cup","world-cup",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":107,"slug":109},10,"Lifestyle","lifestyle",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":80,"slug":113},19,"General","general",{"code":4,"msg":65,"data":115},{"doc_id":62,"user_id":116,"nickname":42,"user_avatar":117,"doc_module":4,"category_id":90,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":11,"file_id":118,"file_url":119,"file_type":120,"file_size":121,"view_count":22,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":22,"language":122,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":11,"faqs":11,"seo_title":123,"seo_description":12,"update_tm":63,"read_time":30},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","cbCainfNMGcR2CZu","https://ap.wps.com/l/cbCainfNMGcR2CZu","pdf",1055581,"English","HUS | PDF"]