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Sixty male Sprague-Dawley rats were allocated to control, model, and three hUC-MSC dose groups. hUC-MSCs improved body weight, fecal water content, inflammatory factor expression, intestinal barrier protein levels, and gut microbiota abundance and 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Cells |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Stem Cells 2025 December 26; 17(12): 112100  \nDOI: 10.4252/wjsc.v17.i12.112100 ISSN 1948-0210 (online)  \nORIGINAL ARTICLE  \nBasic Study  \nHuman umbilical cord mesenchymal stem cells alleviated diarrheatype irritable bowel syndrome by improving intestinal function  \nHe-Ming Zhang, Yu Zhang, Guang-Jie Luo, An-Xing Zhang, Ruo-Chang Li, Hai-Bo Dong, Teng-Yun Dong, Peng-Cheng Yu, Ying An, Yan Li  \nSpecialty type: Cell and tissue engineering  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade C, Grade C, Grade C  \nNovelty: Grade C, Grade C, Grade C  \nCreativity or Innovation: Grade B, Grade C, Grade C  \nScientific Significance: Grade C, Grade C, Grade C  \nP-Reviewer: Li SJ, PhD, Assistant Professor, China; Yu TY, MD, PhD, China  \nReceived: July 18, 2025  \nRevised: August 19, 2025  \nAccepted: November 6, 2025  \nPublished online: December 26, 2025  \nProcessing time: 160 Days and 20.6 Hours  \nHe-Ming Zhang, Yu Zhang, An-Xing Zhang, Ruo-Chang Li, Ying An, Yan Li, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan Province, China  \nGuang-Jie Luo, Hai-Bo Dong, Teng-Yun Dong, Hubei Engineering Research Center for Human Stem Cell Preparation, Application and Resource Preservation, Wuhan Optics Valley Vcanbio Pharma Co. Ltd., Wuhan 430000, Hubei Province, China  \nPeng-Cheng Yu, Department of Production Technology, Yunnan Heze Southwest Bioscience  \nCo. Ltd., Kunming 650032, Yunnan Province, China Co-first authors: He-Ming Zhang and Yu Zhang.  \nCorresponding author: Yan Li, PhD, Professor, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Xishan District, Kunming 650032, Yunnan Province, [China.](China. hepatocellular@sina.com)[ hepatocellular@sina.com](China. hepatocellular@sina.com)  \nAbstract  \nBACKGROUND  \nIrritable bowel syndrome (IBS) is a complex bowel disorder marked by recurrent abdominal pain and irregular stools. The condition is persistent and significantly affects the quality of life of patients. In China, 5.6%-11.5% of the population has IBS, with diarrheal IBS (IBS-D) comprising about 31.5% of the total.  \nAIM  \nTo investigate how human umbilical cord mesenchymal stem cells (hUC-MSCs) can alleviate the symptoms with the help of an IBS-D rat model.  \nMETHODS  \nSixty specific pathogen-free-grade male Sprague-Dawley rats were acquired and divided into five groups: Control group, model group, and three hUC-MSC groups with different doses. The model group was induced using a combination of acetic acid and binding stress. We determined the body weight of the mice; analyzed their fecal characteristics, inflammatory factors, and intestinal tissue damage; and conducted intestinal flora analyses.  \n WJSC  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 26, 2025  Volume 17  Issue 12   \nZhang HM et al. hUC-MSCs treat diarrhea-type IBS  \nRESULTS  \nThe results showed that hUC-MSCs observably restored the dramatic weight loss in the rat model and also lowered the fecal water content to some extent. In addition, hUC-MSCs reduced the expression of inflammatory factors to alleviate the inflammatory response and increased the expression of intestinal barrier functional proteins to restore the colon injury by colonizing the colon tissue. In addition, hUC-MSCs were able to maintain the abundance and diversity of gut flora.  \nCONCLUSION  \nThus, hUC-MSCs can reduce the expression of inflammatory factors, improve the expression of intestinal barrier functional proteins, and maintain the abundance and diversity ","cbCairJsWikfLOmf","https://ap.wps.com/l/cbCairJsWikfLOmf","pdf",48513145,21,"English","# Background\n## Aim\n## Methods\n## Results\n## Conclusion\n## Key Words","[{\"question\":\"What condition does the study address?\",\"answer\":\"The study addresses diarrhea-type irritable bowel syndrome (IBS-D), a chronic functional digestive disorder associated with recurrent abdominal pain and irregular stools.\"},{\"question\":\"How were the hUC-MSCs evaluated?\",\"answer\":\"hUC-MSCs were evaluated in an IBS-D rat model using sixty male Sprague-Dawley rats divided into control, model, and three treatment groups with different doses.\"},{\"question\":\"What outcomes did hUC-MSCs improve in the rat model?\",\"answer\":\"hUC-MSCs restored weight loss, reduced fecal water content, lowered inflammatory factor expression, increased intestinal barrier functional protein expression, supported colon injury recovery, and maintained gut flora abundance and diversity.\"}]","Human umbilical cord mesenchymal stem cells alleviated diarrhea-type irritable bowel syndrome by improving intestinal function | PDF",1790568554,53]