[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31942":3,"doc-seo-31942":26},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":11,"language":20,"language_code":21,"table_of_contents":22,"faqs":23,"seo_title":13,"seo_description":14,"update_tm":24,"read_time":25},31942,687197207639,"Asher","https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd",8,"Research & Report","Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Inhibit PCOS-Associated Granulosa Cell Inflammation","Polycystic ovary syndrome (PCOS) is a common endocrine disorder marked by ovulatory dysfunction, hyperandrogenism, and polycystic ovaries, and is strongly linked to chronic low-grade inflammation. Granulosa cells are key regulators of follicle and oocyte health, and inflammatory cytokines in granulosa cells can impair oocyte development and reduce oocyte quality. Mesenchymal stem cells, including human umbilical cord MSCs, are recognized for immunomodulatory and anti-inflammatory properties. This study investigates how hUC-MSC-derived exosomes influence granulosa cell inflammation in PCOS patients and explores underlying molecular mechanisms.","cbCaij7I3vt9M4gH","https://ap.wps.com/l/cbCaij7I3vt9M4gH","pdf",4155381,1,"English","en","# Introduction\n## Inflammation in PCOS and granulosa cell dysfunction\n## MSCs and exosomes as therapeutic mediators\n# Materials and methods\n## Subjects\n## Main reagents","[{\"question\":\"Why is inflammation considered important in the development of PCOS?\",\"answer\":\"PCOS patients show chronic low-grade inflammation with abnormally high pro-inflammatory factors, suggesting inflammatory mechanisms contribute to PCOS pathogenesis.\"},{\"question\":\"How do granulosa cells relate to oocyte quality in PCOS?\",\"answer\":\"Granulosa cells support oocyte nutrients and growth regulators and act as sensors for follicle and oocyte health; inflammatory cytokines in granulosa cells can impair oocyte development and lower oocyte quality.\"},{\"question\":\"What is the study’s focus regarding MSCs in PCOS?\",\"answer\":\"The study examines the effect of human umbilical cord MSC-derived exosomes on inflammation in PCOS granulosa cells and analyzes the molecular mechanisms involved.\"}]",1780520566,20,{"code":4,"msg":27,"data":28},"ok",{"site_id":29,"language":21,"slug":30,"title":13,"keywords":31,"description":14,"schema_data":32,"social_meta":83,"head_meta":85,"extra_data":87,"updated_unix":24},105,"human-umbilical-cord-mesenchymal-stem-cell-derived-exosomes-inhibit-pcos-associated-granulosa-cell-inflammation","",{"@graph":33,"@context":82},[34,51,65],{"@type":35,"itemListElement":36},"BreadcrumbList",[37,41,45,48],{"item":38,"name":39,"@type":40,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":42,"name":43,"@type":40,"position":44},"https://docshare.wps.com/document/","Document",2,{"item":46,"name":12,"@type":40,"position":47},"https://docshare.wps.com/document/research-report/",3,{"item":49,"name":13,"@type":40,"position":50},"https://docshare.wps.com/document/human-umbilical-cord-mesenchymal-stem-cell-derived-exosomes-inhibit-pcos-associated-granulosa-cell-inflammation/31942/",4,{"url":49,"name":13,"@type":52,"author":53,"headline":13,"publisher":55,"fileFormat":58,"description":14,"dateModified":59,"datePublished":59,"encodingFormat":58,"isAccessibleForFree":60,"interactionStatistic":61},"DigitalDocument",{"name":9,"@type":54},"Person",{"url":38,"name":56,"@type":57},"DocShare","Organization","application/pdf","2026-06-03",true,{"@type":62,"interactionType":63,"userInteractionCount":4},"InteractionCounter",{"@type":64},"ViewAction",{"@type":66,"mainEntity":67},"FAQPage",[68,74,78],{"name":69,"@type":70,"acceptedAnswer":71},"Why is inflammation considered important in the development of PCOS?","Question",{"text":72,"@type":73},"PCOS patients show chronic low-grade inflammation with abnormally high pro-inflammatory factors, suggesting inflammatory mechanisms contribute to PCOS pathogenesis.","Answer",{"name":75,"@type":70,"acceptedAnswer":76},"How do granulosa cells relate to oocyte quality in PCOS?",{"text":77,"@type":73},"Granulosa cells support oocyte nutrients and growth regulators and act as sensors for follicle and oocyte health; inflammatory cytokines in granulosa cells can impair oocyte development and lower oocyte quality.",{"name":79,"@type":70,"acceptedAnswer":80},"What is the study’s focus regarding MSCs in PCOS?",{"text":81,"@type":73},"The study examines the effect of human umbilical cord MSC-derived exosomes on inflammation in PCOS granulosa cells and analyzes the molecular mechanisms involved.","https://schema.org",{"og:url":49,"og:type":84,"og:title":13,"og:site_name":56,"og:description":14},"article",{"robots":86,"canonical":49},"index,follow",{"doc_id":7,"site_id":29}]