[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331297-105":59,"doc-detail-331297-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","human-papillomavirus-infection-of-the-fallopian-tube-as-a-potential-risk-factor-for-epithelial-ovarian-cancer","Human papillomavirus infection of the fallopian tube as a potential risk factor for epithelial ovarian cancer","","Human papillomavirus and related herpesviruses are analyzed in relation to epithelial ovarian cancer by measuring HPV16/18, cytomegalovirus (CMV), and Epstein-Barr virus (EBV) DNA in peripheral blood, ovarian, and fallopian tube (FT) tissues from 97 epithelial ovarian cancer (EOC) patients and 60 controls. DNA is assessed using PCR, including droplet digital PCR. HPV16 DNA appears in about one-third of FT and tumor samples, with higher prevalence and quantity in FT from high-grade serous ovarian carcinoma cases. CMV and EBV are present in roughly one-seventh of EOC samples, supporting HPV16 as a potential EOC risk factor.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/human-papillomavirus-infection-of-the-fallopian-tube-as-a-potential-risk-factor-for-epithelial-ovarian-cancer/331297/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/human-papillomavirus-infection-of-the-fallopian-tube-as-a-potential-risk-factor-for-epithelial-ovarian-cancer/331297.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Which viral DNA targets are measured in this study?","Question",{"text":112,"@type":113},"The study measures HPV16 and HPV18, as well as cytomegalovirus (CMV) and Epstein-Barr virus (EBV) DNA.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was viral DNA detected in patient samples?",{"text":117,"@type":113},"DNA isolates were analyzed using PCR methods, including droplet digital PCR.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the main finding regarding HPV16 and epithelial ovarian cancer risk?",{"text":121,"@type":113},"HPV16 DNA is detected in about one-third of fallopian tube and tumor samples from EOC patients, with higher prevalence and quantity in fallopian tube tissue from high-grade serous cases, suggesting HPV16 may be a potential risk factor for EOC development.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331297,1789996425,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41,"preview_page_count":4},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nHuman papillomavirus infection of the fallopian tube as a potential risk factor for epithelial ovarian cancer  \nEdyta Paradowska1,7􀀍, DariaA. Haręża1,2,7, Katarzyna D. Kania1, Dariusz Jarych1, Miłosz Wilczyński3, Andrzej Malinowski3, Monika Kawecka1,6, Mateusz Nowak4 &  \nJacek R. Wilczyński4,5  \nHuman papillomaviruses (HPVs) and herpesviruses are detected in patients with epithelial ovarian cancer (EOC). We sought to analyze the prevalence of HPV’s 16 and 18, cytomegalovirus (CMV), and Epstein-Barr virus (EBV) DNA in peripheral blood, ovarian, and fallopian tube (FT) tissue samples collected from 97 EOC patients, including 71 cases of high-grade serous ovarian carcinoma (HGSOC), and from 60 women with other tumors or non-neoplastic gynecological diseases. DNA isolates were analyzed by PCR methods, including droplet digital PCR. The results demonstrate that (1) HPV16 DNA has been detected in one-third of the FT and tumor samples from EOCs; (2) the prevalence and quantity of HPV16 DNA were significantly higher in FT samples from HGSOCs, non-HGSOCs, and ovarian metastases than in those from non-neoplastic diseases; (3) CMV and EBV have been detected in approximately one-seventh of EOC samples. The results suggest that HPV16 might be a potential risk factor for EOC development.  \nKeywords Epithelial ovarian cancer, Fallopian tube, Papillomavirus, Herpesvirus, High-grade serous ovarian carcinoma  \nOvarian cancer (OC) affected almost 314 thousand women and was a reason for at least 207 thousand deaths in 2020 worldwide1. In 2023, approximately 19.7 thousand new cases of OC and 13.2 thousand deaths were likely to be reported in the United States2. This cancer is currently the eighth most common women’s cancer and the eighth cause of cancer death in women. The high mortality rate is caused by asymptomatic tumor growth and the lack of appropriate screening tests that allow for early diagnosis of the disease. Epithelial OC (EOC) is the most common type of OC, occurring in more than 90% of cases. EOC consists of the four most common subtypes, including serous, endometrioid, clear cell, and mucinous carcinoma3,4. They can affect the ovaries, fallopian tubes (FT), and the primary peritoneal cavity. However, the most fatal epithelial cancer is that of the serous histology. More than 90% of serous carcinomas are very aggressive high-grade serous ovarian carcinomas (HGSOCs), while 10% are low-grade serous ovarian carcinomas (LGSOCs), which generally leading to a better prognosis5. HGSOC is the most lethal gynecological cancer with a 5-year survival rate of only approximately 30% in patients diagnosed at an advanced stage6. The fallopian tube epithelium (FTE) and ovarian surface epithelium (OSE) are considered to be the HGSOC cell of origin7. In FTE, the presence of proliferative lesions known as serous tubal intraepithelial carcinoma (STIC) is observed8,9. Approximately 80% of ovarian HGSOCs are associated with the involvement ofFT fimbria, including the form of STIC10. As demonstrated using mouse models as well as FTE-and OSE-derived organoids, HGSOC can originate from both cell lineages11. The cell of origin of HGSOC plays an important role in progression, metastasis, and drug response. Ovarian tumors possess a unique tumor microenvironment (TME) whose immunosuppressive features are associated with shorter overall survival rates. HGSOC is characterized by TP53 mutations in almost all tumors (96%)12. Other common  \n1Laboratory of Virology, The Institute of Medical Biology, Polish Academy of Sciences, 106 Lodowa St., 93-232 Lodz, Poland. 2BioMedChem Doctoral School of the University of Lodz and the Institutes ofthe Polish Academy of Sciences in Lodz, Lodz, Poland. 3Department of Surgical, Endoscopic and Oncological Gynecology, Polish Mother’s Health Center Research Institute, Lodz, Poland. 4Department of Gynecology and Obstetrics, Tomaszow Health Center, Tomaszow ","cbCaihHyrY4eXA7I","https://ap.wps.com/l/cbCaihHyrY4eXA7I","pdf",1742839,12,"English","# Introduction\n## Epidemiology and clinical burden of epithelial ovarian cancer\n## Subtypes, survival, and role of fallopian tube epithelium\n## Risk factors and inflammatory/infectious contributions\n## HPV biology and relevance to malignancy","[{\"question\":\"Which viral DNA targets are measured in this study?\",\"answer\":\"The study measures HPV16 and HPV18, as well as cytomegalovirus (CMV) and Epstein-Barr virus (EBV) DNA.\"},{\"question\":\"How was viral DNA detected in patient samples?\",\"answer\":\"DNA isolates were analyzed using PCR methods, including droplet digital PCR.\"},{\"question\":\"What is the main finding regarding HPV16 and epithelial ovarian cancer risk?\",\"answer\":\"HPV16 DNA is detected in about one-third of fallopian tube and tumor samples from EOC patients, with higher prevalence and quantity in fallopian tube tissue from high-grade serous cases, suggesting HPV16 may be a potential risk factor for EOC development.\"}]","Human papillomavirus infection of the fallopian tube as a potential risk factor for epithelial ovarian cancer | PDF",1789992571]