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Screening for precancerous lesions is an effective approach to prevent HPV-related tumors. While HPV vaccination has reduced cervical cancer incidence, universal coverage remains difficult due to cost barriers, especially in low-resource, economically disadvantaged regions. This review updates HPV infection characteristics, screening methods, and strategies tailored to such settings, addressing global burden, implementation disparities, and future research directions to support scalable programs.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/human-papillomavirus-infection-and-screening-strategies/374498/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/human-papillomavirus-infection-and-screening-strategies/374498.png","ImageObject",300,407,{"name":92,"@type":93},"Alex Sinclair","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is HPV infection a major driver of cancers covered in this review?","Question",{"text":112,"@type":113},"The review states that persistent infection with high-risk HPV types, such as HPV 16 and HPV 18, can lead to malignant transformation and progression to invasive cervical cancer over years or decades.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does screening help prevent HPV-related tumors?",{"text":117,"@type":113},"Screening for precancerous lesions enables early detection and timely treatment, which the document notes can significantly reduce mortality from HPV-related cancers.",{"name":119,"@type":110,"acceptedAnswer":120},"What challenge is emphasized for HPV vaccination coverage and screening implementation?",{"text":121,"@type":113},"The document highlights cost barriers and uneven implementation, particularly in economically disadvantaged, low-resource regions, limiting universal coverage and comprehensive programs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},374498,1790241140,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},1099523882182,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","| W | J | C | O | World Journal of\u003Cbr>Clinical Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Oncol 2025 May 24; 16(5): 105055  \nDOI: 10.5306/wjco.v16.i5.105055 ISSN 2218-4333 (online)  \nREVIEW  \nHuman papillomavirus infection and screening strategies  \nSi-He Chen, Yu-Ying Song, Ni Gan, Pin-Tian Wang, Kang Yan, Si-Feng Wang, Yue-E Zu, Xiang-Wen Peng  \nSpecialty type: Oncology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade A, Grade C, Grade C  \nNovelty: Grade A, Grade B, Grade C, Grade C  \nCreativity or Innovation: Grade A, Grade A, Grade C, Grade D Scientific Significance: Grade A, Grade A, Grade C, Grade C  \nP-Reviewer: Janyakhantikul S; Li MY; Liu Y  \nReceived: January 10, 2025  \nRevised: February 26, 2025  \nAccepted: March 26, 2025  \nPublished online: May 24, 2025  \nProcessing time: 130 Days and 15.1 Hours  \nSi-He Chen, Yu-Ying Song, Ni Gan, Pin-Tian Wang, Kang Yan, Si-Feng Wang, Yue-E Zu, Xiang-Wen Peng, Central Laboratory, Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care  \nAffiliated to Hunan Normal University, Changsha 410001, Hunan Province, China Co-first authors: Si-He Chen and Yu-Ying Song.  \nCo-corresponding authors: Yue-E Zu and Xiang-Wen Peng.  \nCorresponding author: Xiang-Wen Peng, Associate Professor, Central Laboratory, Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control, Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, No. 416 East Chengnan Road, Yuhua District, Changsha 410001, Hunan Province, China.  \n[pxw1237@163.com](pxw1237@163.com)  \nAbstract  \nHuman papillomavirus (HPV) infection is a common sexually transmitted disease and a leading cause of cervical, other anogenital, and oropharyngeal cancers. Screening for precancerous lesions is an effective strategy for preventing HPVrelated tumors. Although HPV vaccination has significantly reduced the incidence of cervical cancer, achieving universal coverage remains challenging because of cost barriers, particularly in economically disadvantaged regions. This review provides an update of HPV infection characteristics, screening methods, and strategies tailored to low-resource settings. We also discuss the global burden of HPV-related diseases, regional disparities in the implementation of screening, and future research directions. By examining the current challenges and opportunities, this review aims to inform policymakers and healthcare providers in designing effective, affordable, and scalable screening programs.  \nKey Words: Human papillomavirus; Cervical cancer; Screening strategy; Vaccination  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \n WJCO  [https://www.wjgnet.com](https://www.wjgnet.com) 1 May 24, 2025  Volume 16  Issue 5   \nChen SH et al. HPV infection and screening strategies  \nCore Tip: Human papillomavirus (HPV) is the main cause of cervical cancer, and screening for precancerous lesions is an effective measure to prevent tumors caused by HPV. Although HPV vaccination can effectively prevent the occurrence of cervical cancer, universal coverage cannot be achieved due to the cost. For economically disadvantaged areas, affordable and effective HPV cervical cancer screening strategies remain a major public health concern. Therefore, it is necessary to summarize the prevention and control methods and strategies of HPV virus screening to provide references for countries to formulate public policy research.  \nCitation: Chen SH, Song YY, Gan N, Wang PT, Yan K, Wang SF, Zu YE, Peng XW. Human papillomavirus infection and screening strategies. World J Clin Oncol 2025; 16(5): 105055  \nURL: [https://www.wjgnet.com/221","cbCaikl5uSTvnVF7","https://ap.wps.com/l/cbCaikl5uSTvnVF7","pdf",521978,16,"English","# Abstract\n# Core Tip\n# Introduction\n## Cervical cancer burden\n## Role of high-risk HPV infection\n## Pathogenesis and progression\n## Importance of early detection\n## Screening and vaccination approaches\n# Citation","[{\"question\":\"Why is HPV infection a major driver of cancers covered in this review?\",\"answer\":\"The review states that persistent infection with high-risk HPV types, such as HPV 16 and HPV 18, can lead to malignant transformation and progression to invasive cervical cancer over years or decades.\"},{\"question\":\"How does screening help prevent HPV-related tumors?\",\"answer\":\"Screening for precancerous lesions enables early detection and timely treatment, which the document notes can significantly reduce mortality from HPV-related cancers.\"},{\"question\":\"What challenge is emphasized for HPV vaccination coverage and screening implementation?\",\"answer\":\"The document highlights cost barriers and uneven implementation, particularly in economically disadvantaged, low-resource regions, limiting universal coverage and comprehensive programs.\"}]","Human papillomavirus infection and screening strategies | PDF",1790201781]