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It discusses why paediatric cancers differ from adult cancers and the need for more precise therapies with fewer long-term effects. The issue features Professor Ron Firestein’s work on the Childhood Cancer Model Atlas (CCMA), including its open-source, high-risk cell line collection and collaborative publication. 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Donate today.  \n2 HUDSON NEWS WINTER 2023  \nDirector’s message  \nProfessor Elizabeth Hartland  \nFor children with cancer, change starts here  \nChildhood cancer is rare but devastating, and new treatment options are desperately needed. In the last four decades, the US Food and Drug Authority (FDA) has approved 500 drugs for adult cancers but just 12 to treat childhood cancers.  \nChildren’s cancers are not the same as adult cancers, and the impact of treatments on the developing body can lead to long-term detrimental effects on survivors. We need better and more precise therapeutics to increase survival and reduce the side effects of treatment.  \nAs you’ll read, our Winter 2023 Hudson News has a focus on childhood cancer research under the leadership of Professor Ron Firestein, Head of our Centre for Cancer Research, and also co-leader of the Victorian Paediatric Cancer Consortium (VPCC) .  \nOur science offers hope that another childlike Luca Boggia, who you’ll read more about in this edition, will benefit from improved therapies and avoid harrowing rounds of chemotherapy or radiotherapy as a result of our research.  \nYou’ll hear more about how our Childhood Cancer Model Atlas (CCMA), the world’s largest collection of high-risk paediatric cancer cell lines, was developed at Hudson Institute, providing a unique open-source facility to paediatric oncologists and cancer researchers worldwide.  \nThe story of the CCMA was recently published in the prestigious journal Cancer Cell, explaining how it was developed through active collaborations with 34 cancer research institutes, universities and academic medical centres. We are proud to be driving this worldwide collaborative work that will change the landscape of childhood cancer research.  \nWhile cancer affects so many lives negatively, it can also spur on amazing action. You’ll hear more about one of our incredible donors who decided to give while living to osteosarcoma research in Dr Jason Cain’s lab.  \nThis edition has a major focus on childhood cancer, but we also feature a story on our team of researchers, including PhD student Elisabeth Ng and Associate Professor Jun Yang, who are pioneering better detection and treatment of a major undiagnosed cause of hypertension, affecting around 600,000 Australians.  \nYour annual flu update comes from Associate Professor Michelle Tate, a leading expert on the flu and RSV viruses. She explains how to prepare and what to look out for this flu season.  \nYou can read more about our research on our website or stay up to date with it all by subscribing to our mailing list.  \nFor those who generously donated to our Festive Health Appeal earlier in the year, I’d also like to thank you for your support.  \nAs we work towards innovative treatmentsand cures for childhood cancer, your continued support is key to ensuring that our scientists can solve important challenges like these for more children.  \nWe hope that the updates in this newsletter inspire you to give generously. With your commitment, together we can support the research that helps improve survival rates and quality of life for thousands of children.  \nWith gratitude,  \nProfessor Elizabeth Hartland  \nDirector and CEO  \nCover image: The Boggia family of (L-R) Monique, Luca (rare brain tumour survivor) and Baden in a park  \nIn this issue  \n• Hope, from the depths of despair  \n• Tackling hypertension at the source  \n• Giving while living to help cancer research  \n• What you need to know about the flu in 2023—with A/Prof Michelle Tate  \nWant to keep up to date with Hudson Institute’s latest discoveries?  \nSign up to our mailing list at [www.hudson.org.au](www.hudson.org.au)  \nSuppo","cbCaipTjZxEH0v0I","https://ap.wps.com/l/cbCaipTjZxEH0v0I","pdf",2513034,"English","# Director’s message\n## Hope, from the depths of despair\n## Tackling hypertension at the source\n## Giving while living to help cancer research\n## What you need to know about the flu in 2023","[{\"question\":\"Why does the newsletter emphasize that childhood cancers need different treatments from adult cancers?\",\"answer\":\"It explains that childhood cancers are rare but devastating and that treatments can have long-term detrimental effects on developing survivors, so more precise therapeutics are needed to improve survival and reduce side effects.\"},{\"question\":\"What is the Childhood Cancer Model Atlas (CCMA) and why is it important?\",\"answer\":\"The CCMA is described as the world’s largest collection of high-risk paediatric cancer cell lines stored in an open-source facility, developed at Hudson Institute and used by paediatric oncologists and researchers worldwide.\"},{\"question\":\"How does the issue connect research progress with donations and community support?\",\"answer\":\"It features donor stories and an appeal, emphasizing that continued support helps scientists pursue innovative treatments and cures and tackle important research challenges for more children.\"}]","Hudson News Winter 2023 - Director’s message - Hope, from the depths of despair | PDF",1791034937]