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Patient screening and RNA analysis quantify hsa_circ_0079929 levels across cancerous and adjacent normal tissues, while statistical testing links expression to clinical parameters and survival outcomes. Functional studies assess proliferation, migration, and invasion, and mechanistic work identifies hsa_circ_0079929 as a miR-1184 molecular decoy.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hsa_circ_0079929-in-lung-adenocarcinoma-and-its-biological-implications-in-lung-adenocarcinoma-progression-research-open-access/331341/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hsa_circ_0079929-in-lung-adenocarcinoma-and-its-biological-implications-in-lung-adenocarcinoma-progression-research-open-access/331341.png","ImageObject",300,407,{"name":92,"@type":93},"Riley","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What is hsa_circ_0079929 and why was it studied in lung adenocarcinoma?","Question",{"text":112,"@type":113},"The study focuses on the expression level and biological implications of hsa_circ_0079929 in lung adenocarcinoma, evaluating both prognostic significance and functional effects during disease progression.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the relationship between hsa_circ_0079929 expression and patient prognosis analyzed?",{"text":117,"@type":113},"Clinical data and tissue samples were collected, hsa_circ_0079929 levels were measured by RNA analysis, and associations with outcomes were tested using Chi-square, multivariate Cox regression, and Kaplan-Meier curves.",{"name":119,"@type":110,"acceptedAnswer":120},"What cellular behaviors are affected by hsa_circ_0079929 overexpression or knockdown?",{"text":121,"@type":113},"Overexpression was associated with increased proliferation, migration, and invasion, while knockdown inhibited these malignant cellular features.",{"name":123,"@type":110,"acceptedAnswer":124},"What mechanistic role does hsa_circ_0079929 play in lung adenocarcinoma cells?",{"text":125,"@type":113},"Hsa_circ_0079929 functions as a molecular decoy for miR-1184 in lung adenocarcinoma cells.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},331341,1791068386,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149,"preview_page_count":4},1374391975076,"https://ap-avatar.wpscdn.com/avatar/14000253ca4ec9f6853?x-image-process=image/resize,m_fixed,w_180,h_180&k=1783305029341752051","Shen et al. Journal of Cardiothoracic Surgery (2024) 19:549  \n[https://doi.org/10.1186/s13019-024-03075-1](https://doi.org/10.1186/s13019-024-03075-1)  \nJournal of Cardiothoracic Surgery  \nRESEARCH Open Access  \nHsa_circ_ 0079929 in lung adenocarcinoma and its biological implications in lung adenocarcinoma progression  \nYuan Shen 1, Ruixue Han2, Xin Yu3 and Jing Mao4*  \nAbstract  \nBackground This report investigated the expression, prognostic and biological implications of hsa_circ_0079929 in lung adenocarcinoma, which was based on clinical and experimental data.  \nMethods Patients with lung adenocarcinoma were screened and their clinical data and tissues (including cancerous tissues and adjacent normal tissues) were collected. The total RNA in tissues and cell lines was analyzed to obtained hsa_circ_0079929 level. The clinical significance was examined using the Chi-square test, Multi-variate Cox proportional hazards regression, and Kaplan-Meier curve. Cell malignant features were evaluated from three aspects (proliferation, migration, and invasion), detected by CCK-8 and Transwell methods.  \nResults Hsa_circ_0079929 raised in expression level in lung adenocarcinoma. This upregulation of hsa_circ_0079929 was correlated with adverse clinical parameters and poor outcome in terms of overall survival, resulting in an independent prognostic purpose molecular for overall survival. Overexpression of hsa_circ_0079929 could contribute to cell proliferation/migration/invasion, whereas its knockdown could inhibit these malignant features. Hsa_circ_ 0079929 was a molecular decoy for miR-1184 in lung adenocarcinoma cells.  \nConclusions Hsa_circ_0079929 could promote the malignant features of lung adenocarcinoma cells and may aid the follow up and therapeutic target discovery of lung adenocarcinoma.  \nKeywords Lung adenocarcinoma, Hsa_circ_ 0079929, Prognosis, Progression  \n*Correspondence:  \nJing Mao  \n[Drmaojing299@163.com](Drmaojing299@163.com)  \n1Department of Internal Medicine, Huzhou Jiaotong Hospital, Huzhou 313000, China  \n2Department of Oncology, Yuhuan Second People’s Hospital, Yuhuan 317605, China  \n3Department of Respiratory Medicine, Traditional Chinese Medical Hospital of Zhuji, Zhuji 311800, China  \n4Department of Respiratory and Critical Care Medicine, Binhai County People’s Hospital, No. 299, Haibin Avenue, Binhai County, Yancheng 224500, China  \nBackground  \nLung adenocarcinoma remains the common fatal subtype of non-small cell lung cancer, with a share of 40–50% in all lung cancers [1, 2] . Most lung adenocarcinomas originate from the bronchial epithelium, anda few originate from the mucous glands of the large bronchi [3] . The disease progresses slowly, and initial symptoms are generally less obvious [4] . The incidence and mortality of lung adenocarcinoma are increasing year by year [5] . Percent of cases and 5-year relative survival by stage at diagnosis ranged from 57.4 to 5.2%[6, 7] . Small-molecule tyrosine kinase inhibitors and immunotherapies are already in use, bringing  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To","cbCaigNLUoFC07ee","https://ap.wps.com/l/cbCaigNLUoFC07ee","pdf",1816731,11,"English","# Background\n# Methods\n# Results\n# Conclusions\n# Keywords","[{\"question\":\"What is hsa_circ_0079929 and why was it studied in lung adenocarcinoma?\",\"answer\":\"The study focuses on the expression level and biological implications of hsa_circ_0079929 in lung adenocarcinoma, evaluating both prognostic significance and functional effects during disease progression.\"},{\"question\":\"How was the relationship between hsa_circ_0079929 expression and patient prognosis analyzed?\",\"answer\":\"Clinical data and tissue samples were collected, hsa_circ_0079929 levels were measured by RNA analysis, and associations with outcomes were tested using Chi-square, multivariate Cox regression, and Kaplan-Meier curves.\"},{\"question\":\"What cellular behaviors are affected by hsa_circ_0079929 overexpression or knockdown?\",\"answer\":\"Overexpression was associated with increased proliferation, migration, and invasion, while knockdown inhibited these malignant cellular features.\"},{\"question\":\"What mechanistic role does hsa_circ_0079929 play in lung adenocarcinoma cells?\",\"answer\":\"Hsa_circ_0079929 functions as a molecular decoy for miR-1184 in lung adenocarcinoma cells.\"}]","Hsa_circ_0079929 in lung adenocarcinoma and its biological implications in lung adenocarcinoma progression - Research open access | PDF",1789992740,28]