[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-406479-105":59,"doc-detail-406479-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","hpv-related-diseases-in-male-patients-an-underestimated-conundrum","HPV-related diseases in male patients - an underestimated conundrum","","A review examines human papillomavirus (HPV) infection as a prevalent sexually transmitted disease in males and females, highlighting that male patients have been underrepresented in research despite substantial worldwide burden. The study analyzes literature on male HPV infection in relation to head and neck conditions, cancers, warts and condylomas, male infertility and semen findings, and mechanistic in vitro and vaccination-adjunct evidence. Findings emphasize high prevalence, clinical underestimation, and public-health implications, noting limited promotion of vaccination in young males.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hpv-related-diseases-in-male-patients-an-underestimated-conundrum/406479/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hpv-related-diseases-in-male-patients-an-underestimated-conundrum/406479.png","ImageObject",300,407,{"name":92,"@type":93},"Blue Pony","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main purpose of the review on HPV in male patients?","Question",{"text":113,"@type":114},"To focus on HPV-related diseases in male patients, addressing the gap created by the much larger focus on female HPV programs and outcomes.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which databases and study types were included in the analysis?",{"text":118,"@type":114},"PubMed literature was analyzed, including randomized trials, observational and retrospective studies, and original articles on male HPV infection related to specific cancers, warts/condylomas, male infertility and semen parameters, and anti-sperm antibodies.",{"name":120,"@type":111,"acceptedAnswer":121},"What key relationships does the review highlight between HPV and male health outcomes?",{"text":122,"@type":114},"It links HPV to head and neck HPV-attributable cancer increases, high HPV prevalence in male genital and anal regions, associations with penile cancers, and semen infection reported in general and infertility populations, particularly relating to asthenozoospermia and anti-sperm antibodies.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},406479,1790774704,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},962090760266,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Journal of Endocrinological Investigation (2024) 47:261–274  \n[https://doi.org/10.1007/s40618-023-02192-3](https://doi.org/10.1007/s40618-023-02192-3)  \nHPV‑related diseases in male patients: an underestimated conundrum  \nA. Garolla1 · A. Graziani1 · G. Grande1 · C. Ortolani2 · A. Ferlin1  \nReceived: 21 June 2023 / Accepted: 28 August 2023 / Published online: 28 September 2023 © The Author(s) 2023  \nAbstract  \nPurpose Human papillomavirus (HPV) infection is the most common sexually transmitted disease, in males and females worldwide. While the role of HPV in female diseases is well known and largely studied, males have negligibly been included in these programs, also because the proportion of women suffering and dying from HPV-related diseases is much larger than men. The aim of this review is to focus on HPV-related diseases in male patients.  \nMethods We performed a literature analysis on the electronic database PubMed. We considered randomized trials, observational and retrospective studies, original articles having as topic the relationship between HPV male infection and the following items: oral, anal penile cancers, warts, condylomas, male infertility, altered sperm parameters, anti-sperm antibodies (ASA) . We also included experimental in vitro studies focused on the effects of HPV infection on oocyte fertilization, blastocyst development, and trophoblastic cell invasiveness. In addition, studies describing the adjuvant administration of the HPV vaccination as a possible strategy to promote HPV clearance from semen in infected males were included.  \nResults Regarding head and neck HPV-related diseases, the most important non-neoplastic disease is recurrent respiratory papillomatosis (RRP) . Regarding neoplastic diseases, the proportion of head and neck cancers attributable to HPV has increased dramatically worldwide. In addition, nowadays, it is thought that half of head and neck squamous cell carcinomas (HNSCCs) cases in the United States are caused by infection with high-risk HPV. HPV is noteworthy in andrological practice too. It was described as having a high HPV prevalence, ranging between 50 and 70%, in male penile shaft, glans penis/ coronal sulcus, semen as well as in scrotal, perianal, and anal regions. Moreover, in male patients, HPV infection has been associated, among other diseases, with penile cancers. HPV semen infection has been reported in about 10% in men from the general population and about 16% in men with unexplained infertility, although these data seem widely underestimated according to clinical experience. In particular, HPV semen infection seems to be most related to asthenozoospermia and to anti-sperm antibodies (ASAs) .  \nConclusions HPV infection represents a health problem with a detrimental social and public impact. Despite this evidence, little has been done to date to widely promote vaccination among young males.  \nKeywords HPV · HPV-related diseases · Head and neck cancer · Male HPV · Male infertility · Sperm parameters  \nA. Garolla and A. Graziani are the co-first authors.  \n* A. Garolla [andrea.garolla@unipd.it](andrea.garolla@unipd.it)  \n1 Unit of Andrology and Reproductive Medicine, Department of Medicine, University of Padova, Padua, Italy  \n2 Section of Otolaryngology, Department of Neurosciences, University of Padova, Padua, Italy  \nBackground  \nHuman papillomavirus (HPV) infection is the most common sexually transmitted disease (STD) in males and females worldwide [1, 2] .  \nIt is estimated that the probability of infection with the virus is about 80% in females and 90% in males across their lifetime [3, 4]. The high prevalence of HPV infection in the general population is related to its contagiousness. Despite HPV being mainly transmitted through sexual activity, people can also be easily infected by skin-to skin contact [3] .  \nHPVs belong to the family Papillomaviridae [3] . Papillomaviruses are a family of DNA viruses that infect the  \nepithelium and mucosae and have a double","cbCaihspDOAzJj28","https://ap.wps.com/l/cbCaihspDOAzJj28","pdf",1389860,14,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusions\n# Background\n## Transmission and prevalence\n## HPV types and related diseases\n## High-risk HPV and cancer burden","[{\"question\":\"What is the main purpose of the review on HPV in male patients?\",\"answer\":\"To focus on HPV-related diseases in male patients, addressing the gap created by the much larger focus on female HPV programs and outcomes.\"},{\"question\":\"Which databases and study types were included in the analysis?\",\"answer\":\"PubMed literature was analyzed, including randomized trials, observational and retrospective studies, and original articles on male HPV infection related to specific cancers, warts/condylomas, male infertility and semen parameters, and anti-sperm antibodies.\"},{\"question\":\"What key relationships does the review highlight between HPV and male health outcomes?\",\"answer\":\"It links HPV to head and neck HPV-attributable cancer increases, high HPV prevalence in male genital and anal regions, associations with penile cancers, and semen infection reported in general and infertility populations, particularly relating to asthenozoospermia and anti-sperm antibodies.\"}]","HPV-related diseases in male patients - an underestimated conundrum | PDF",1790565932,35]