[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-370383-105":59,"doc-detail-370383-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","hpv-and-cervical-cancer-biology-prevention-and-treatment-updates","HPV and Cervical Cancer - Biology, Prevention, and Treatment Updates","","Persistent infection with specific human papillomavirus (HPV) genotypes is identified as a key cause of cervical cancer, enabling major advances in both diagnosis and therapy. This review summarizes the latest knowledge on HPV-related cervical cancer, focusing on vaccination strategies, diagnostic testing, and treatment approaches. It highlights current and emerging WHO guidance, then reviews promising developments including self-administered diagnostic testing, therapeutic vaccines, and circulating cell-free DNA. Vaccination and screening remain central to prevention.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hpv-and-cervical-cancer-biology-prevention-and-treatment-updates/370383/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hpv-and-cervical-cancer-biology-prevention-and-treatment-updates/370383.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main cause of cervical cancer discussed in the review?","Question",{"text":113,"@type":114},"The review emphasizes that persistent infection with certain HPV genotypes is the cause of cervical cancer.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which areas of HPV-related cervical cancer are covered?",{"text":118,"@type":114},"The article focuses on the biology of HPV, prevention through vaccination, and updates in diagnostic testing and treatment.",{"name":120,"@type":111,"acceptedAnswer":121},"What emerging diagnostic and treatment approaches are highlighted?",{"text":122,"@type":114},"The review summarizes promising developments such as self-administered diagnostic tests, therapeutic vaccines, and use of circulating cell-free DNA in diagnosis.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},370383,1790228572,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Review  \nHPV and Cervical Cancer—Biology, Prevention, and Treatment Updates  \nEmilia Włoszek 1,*, Kamila Krupa 1, Eliza Skrok 1, Michał Piotr Budzik 2, Andrzej Deptała 2 and Anna Badowska-Kozakiewicz 2  \nReceived: 27 January 2025  \nRevised: 13 February 2025  \nAccepted: 20 February 2025  \nPublished: 22 February 2025  \nCitation: Włoszek, E.; Krupa, K.; Skrok, E.; Budzik, M.P.; Deptała, A.; Badowska-Kozakiewicz, A. HPV and Cervical Cancer—Biology, Prevention, and Treatment Updates. Curr. Oncol. 2025, 32, 122. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/curroncol32030122](10.3390/curroncol32030122)  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Students’ Scientific Organization of Cancer Cell Biology, Department of Oncology Propaedeutics, Medical University of Warsaw, 02-091 Warsaw, Poland; [kamila.krupa@student.wum.edu.pl](kamila.krupa@student.wum.edu.pl) (K.K.); [s085306@student.wum.edu.pl](s085306@student.wum.edu.pl) (E.S.)  \n2 Department of Oncology Propaedeutics, Medical University of Warsaw, 02-091 Warsaw, Poland; [michal.budzik@wum.edu.pl](michal.budzik@wum.edu.pl) (M.P.B.); [andrzej.deptala@wum.edu.pl](andrzej.deptala@wum.edu.pl) (A.D.); [abadowska@wum.edu.pl](abadowska@wum.edu.pl) (A.B.-K.)  \n* Correspondence: [emilia.wloszek@student.wum.edu.pl](emilia.wloszek@student.wum.edu.pl)  \nAbstract: One of the most significant breakthroughs in cancer research has been the identification of persistent infection with certain human papillomaviruses (HPV) genotypes as the cause of cervical cancer. Since then, a range of diagnostic and therapeutic methods has been developed based on this discovery. This article aims to describe the latest updates in the biology, prevention, and treatment of HPV-related cervical cancer. The current state of knowledge regarding vaccinations, diagnostic tests, and cervical cancer therapies is presented. The latest WHO guidelines on vaccinations are presented, as well as announcements of upcoming changes. The final part of the article summarizes promising new diagnostic and treatment methods, as well as perspectives and the latest research findings on self-administered diagnostic tests, the use of therapeutic vaccines, and circulating cell-free DNA in diagnosis. Despite the significant progress made in recent years, the strategy based on vaccination and testing remains the cornerstone in the fight against HPV-related cervical cancer.  \nKeywords: human papillomavirus; HPV; cervical cancer; vaccination; screening; systemic therapy  \n1. Introduction  \nPapillomaviruses are small, double-stranded DNA viruses that specifically infectsquamous epithelia or cells capable of squamous maturation. These viruses are strictly species-specific, meaning that human papillomaviruses (HPVs) exclusively infect humans. They exhibit remarkable tissue tropism, completing their infectious cycle only in fully differentiated squamous epithelium. Over the past 25 years, one of the most significant breakthroughs in cancer research has been the identification of persistent infection with certain HPV genotypes as the cause of cervical cancer. Comprehensive virological, molecular, clinical, and epidemiological studies have provided definitive evidence that cervical cancer results from prolonged, unresolved infection by specific HPV genotypes. Consequently, it is now understood that cervical cancer is the outcome of a viral infection. This recognition highlights vaccination as a vital strategy for the primary prevention of cancers and other diseases associated with HPV. Considering the findings of the research conducted in recent years, HPV infection may be a contributing factor in the development of many other types of canc","cbCaid2hv2Mfnyon","https://ap.wps.com/l/cbCaid2hv2Mfnyon","pdf",1632153,22,"English","# Abstract\n# Introduction\n# Epidemiology\n# Classification of HPV Viruses","[{\"question\":\"What is the main cause of cervical cancer discussed in the review?\",\"answer\":\"The review emphasizes that persistent infection with certain HPV genotypes is the cause of cervical cancer.\"},{\"question\":\"Which areas of HPV-related cervical cancer are covered?\",\"answer\":\"The article focuses on the biology of HPV, prevention through vaccination, and updates in diagnostic testing and treatment.\"},{\"question\":\"What emerging diagnostic and treatment approaches are highlighted?\",\"answer\":\"The review summarizes promising developments such as self-administered diagnostic tests, therapeutic vaccines, and use of circulating cell-free DNA in diagnosis.\"}]","HPV and Cervical Cancer - Biology, Prevention, and Treatment Updates | PDF",1790188261,55]