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A comparison outlines daily PrEP versus 2-1-1 covering eligibility, timing, effectiveness, planning, adherence tolerance, missed doses, and side effects, plus warnings for chronic Hepatitis B and cost considerations.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/how-to-take-prep-2-1-1-for-anal-sex/401296/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/how-to-take-prep-2-1-1-for-anal-sex/401296.png","ImageObject",300,407,{"name":42,"@type":43},"McQueen","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-27",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How should PrEP 2-1-1 be taken before anal sex?","Question",{"text":63,"@type":64},"Take 2 PrEP tablets at least 2 hours and not more than 24 hours before sex.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How should PrEP 2-1-1 be taken after the first 2 tablets?",{"text":68,"@type":64},"Take 1 PrEP tablet 24 hours after the first 2 tablets, then take 1 PrEP tablet every 24 hours until 2 days after your last “sex day.”",{"name":70,"@type":61,"acceptedAnswer":71},"What is the difference between daily PrEP and PrEP 2-1-1, especially for Hepatitis B?",{"text":72,"@type":64},"The handout states daily PrEP can be taken with chronic Hepatitis B, while PrEP 211 may be potentially dangerous with chronic Hepatitis B. 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Do not pick and choose when to use 2-1-1 dosing.\u003Cbr>􀁸 Take the tablets around the same time each day (+/-2 hours) . We suggest setting an alarm or reminder.\u003Cbr>􀁸 Switch to daily PrEP dosing whenever you want to if that is a better fit for you.\u003Cbr>􀁸 If you're unsure when to stop or miss a dose, continue taking PrEP daily and call your PrEP Coordinator/provider for support, or go to urgent care if necessary. |  |\n\nFEATURES OF DAILY VS. 211 DOSING \u003C\u003C\u003C  \nWHO CAN USE IT?  \nWHEN TO USE IT?  \nEFFECTIVENESS  \nTAKING PILLS  \nMISSING DOSES  \nSIDE EFFECTS  \nPLANNING  \nHEPATITIS B  \nCOSTS  \nDaily PrEP  \nAnyone  \nAutomatically use with everyone  \nNo difference based on available evidence  \nIt’s easier to take a pill every day  \nForgiving when taking 5 or more doses in the week  \nNo difference  \nNo planning needed around sex  \nCan take daily with chronic Hepatitis B  \nMay be more expensive if you pay for medications  \nPrEP 211  \nAnal sex only. Not shown to be effective for receptive vaginal/front hole sex  \nMust use with every sexual encounter. Picking and choosing isnot recommended  \nNo difference based on available evidence  \nRequires planning and reminders to take your 211 doses  \nNot forgiving  \nNo difference  \nNeed at least 2 hours’ notice to take PrEP before sex.  \nPotentially dangerous to use with chronic Hepatitis B  \nMay be cheaper if you pay for medications  \nA NOTE ON FDA APPROVAL \u003C\u003C\u003C  \n>>> PRO-TIP  \nOnce-daily Truvada® is currently the only FDA-approved strategy for PrEP. The additional PrEP 211/On-Demand dosing strategy is not specifically endorsed by the FDA, as Gilead, the pharmaceutical company, has not submitted the alternative strategy for FDA approval. However, there is substantial published evidence this dosing strategy will work, requiring less lifetime exposure to Truvada® compared to once-daily dosing.  \nPrEP 211 requires perfect adherence to be highly effective. Use alarms or timer caps to ensure you stay on track and take your pills on time.  \n2 pills: 2 to 24 hours before sex + 1 pill every day you have sex  \n1 pill: 24 hours after previous dose  \n1 pill: 24 hours after that","cbCaioRyXsKF3iwK","https://ap.wps.com/l/cbCaioRyXsKF3iwK","pdf",379259,"English","# HOW TO TAKE: PREP 2-1-1 FOR ANAL SEX\n## Before Sex\n## After Sex\n## Restarting When There Is a Gap\n# A FEW IMPORTANT POINTS\n# A NOTE ON FDA APPROVAL\n# PRO-TIP\n## PrEP 211 Dosing Summary","[{\"question\":\"How should PrEP 2-1-1 be taken before anal sex?\",\"answer\":\"Take 2 PrEP tablets at least 2 hours and not more than 24 hours before sex.\"},{\"question\":\"How should PrEP 2-1-1 be taken after the first 2 tablets?\",\"answer\":\"Take 1 PrEP tablet 24 hours after the first 2 tablets, then take 1 PrEP tablet every 24 hours until 2 days after your last “sex day.”\"},{\"question\":\"What is the difference between daily PrEP and PrEP 2-1-1, especially for Hepatitis B?\",\"answer\":\"The handout states daily PrEP can be taken with chronic Hepatitis B, while PrEP 211 may be potentially dangerous with chronic Hepatitis B. It also notes that PrEP 211 requires planning and reminders and is not forgiving for missed doses.\"}]","How to Take - PrEP 2-1-1 for Anal Sex | PDF",1790518486]