[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-442233-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-442233-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","how-physical-activity-influences-motoric-cognitive-risk-syndrome-in-older-adults-research-study","How physical activity influences motoric cognitive risk syndrome in older adults - Research study","","Motoric cognitive risk (MCR) is a pre-dementia syndrome marked by subjective cognitive complaints and slow gait speed, associated with later cognitive decline and dementia. This population-based cohort study examines how total physical activity and healthy physical activity relate to baseline MCR and incident MCR over 5 years. Mediation analysis evaluates gait speed and cognition, while Cox regression and restricted cubic splines assess longitudinal and nonlinear associations, supported by sensitivity analyses across age groups.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/how-physical-activity-influences-motoric-cognitive-risk-syndrome-in-older-adults-research-study/442233/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/how-physical-activity-influences-motoric-cognitive-risk-syndrome-in-older-adults-research-study/442233.png","ImageObject",300,407,{"name":42,"@type":43},"Aran","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",7,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the objective of the study on MCR in older adults?","Question",{"text":63,"@type":64},"To investigate the relationship between total physical activity, healthy physical activity, and motoric cognitive risk (MCR) in older adults.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was MCR association tested across baseline and follow-up?",{"text":68,"@type":64},"Logistic regression assessed baseline associations, while Cox regression evaluated the risk of incident MCR over a 5-year follow-up.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the mediation and regression analyses show?",{"text":72,"@type":64},"Mediation analysis indicated gait speed significantly mediated the association between physical activity and MCR, and logistic/Cox analyses showed higher physical activity levels were linked to lower MCR risk.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},442233,1790763883,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":55,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},137455076865,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Chen et al. BMC Geriatrics (2026) 26:11 BMC Geriatrics  \n[https://doi.org/10.1186/s12877-025-06824-6](https://doi.org/10.1186/s12877-025-06824-6)  \nRESEARCH Open Access  \nHow physical activity influences motoric cognitive risk syndrome in older adults  \nXin Chen 1,2†, Zihao Zhang3†, Yijiang Zhang4, Lijuan Deng5, Haihua Guo6, Wen-quan Zou3 and Dexin Wang 1,7*  \nAbstract  \nObjective Motoric cognitive risk (MCR) is a pre-dementia syndrome linked to higher risks of cognitive decline and dementia. This study aims to investigate the relationship between total physical activity (TPA), healthy physical activity (PA), and MCR in older adults.  \nStudy design Population-based cohort study with both cross-sectional and longitudinal analyses.  \nMethods Logistic regression was used for cross-sectional analyses to examine the associations between TPA, healthy PA, and MCR at baseline. Using mediation analysis to explore the associations of gait speed and cognition in the link between physical activity and MCR. Cox regression was applied for longitudinal analyses to evaluate the relationships between TPA, healthy PA, and incident MCR risk over a 5-year follow-up. Restricted cubic splines (RCS) were employed to investigate potential nonlinear associations between TPA and MCR risk. Sensitivity analyses were conducted across different age groups to confirm the robustness of the results.  \nResults Logistic regression analysis revealed a significant negative association between TPA, healthy PA, and MCR. Participants engaging in healthy PA had a 36. 9% lower risk of MCR (OR 0 . 631[0 . 502,0 . 793]) . Mediation analysis showed that gait speed significantly mediated the association between PA and MCR. Cox regression further demonstrated that both TPA and healthy PA were significantly related to a lower risk of MCR. RCS analysis identified a nonlinear relationship between TPA and MCR risk, with the lowest risk observed at 86.1 METs. Sensitivity analyses across different age groups confirmed the robustness of these findings.  \nConclusion Higher level s ofTPA and healthy PA are negatively associated with MCR, underscoring the importance of maintaining adequate PA in older adults.  \nKeywords Motoric cognitive risk, Physical activity, Dementia, Gait  \n†Xin Chen and Zihao Zhang contributed equally to this work.  \n*Correspondence:  \nDexin Wang  \n[wangdexing@sus.edu.cn](wangdexing@sus.edu.cn)  \n1School of Athletic Performance, Shanghai University of Sport, Shanghai 200438, China  \n2Chongming District Sports School, Shanghai 202150, China 3Institute of Neurology, The First Affiliated Hospital, Jiangxi Medical College, Jiangxi Academy of Clinical Medical Sciences, Nanchang University, Nanchang, Jiangxi Province 330006, China  \n4Department of Basic Instruction, Information Support Force Engineering University, Wuhan 430030, China  \n5Department of Nephrology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China  \n6Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China  \n7Shanghai Key Lab of Human Performance, Shanghai University of Sport, Shanghai, China  \n© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regula","cbCaifOVwsXkelFy","https://ap.wps.com/l/cbCaifOVwsXkelFy","pdf",2576592,11,"English","# Abstract\n# Introduction\n## Motoric cognitive risk syndrome and dementia risk\n## Motor-cognitive mechanisms and neurodegeneration\n## Physical activity as a protective factor","[{\"question\":\"What is the objective of the study on MCR in older adults?\",\"answer\":\"To investigate the relationship between total physical activity, healthy physical activity, and motoric cognitive risk (MCR) in older adults.\"},{\"question\":\"How was MCR association tested across baseline and follow-up?\",\"answer\":\"Logistic regression assessed baseline associations, while Cox regression evaluated the risk of incident MCR over a 5-year follow-up.\"},{\"question\":\"What did the mediation and regression analyses show?\",\"answer\":\"Mediation analysis indicated gait speed significantly mediated the association between physical activity and MCR, and logistic/Cox analyses showed higher physical activity levels were linked to lower MCR risk.\"}]","How physical activity influences motoric cognitive risk syndrome in older adults - Research study | PDF",1790699514,28]