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The study investigated cumulative lifetime hospitalizations for major cardiovascular events (MCE) in patients aged 75 years or older with CCS and identified clinical predictors. Consecutive outpatients were followed until death. MCEs requiring admission were recorded, while death without admission served as a competing event. Nearly half experienced at least one MCE, mainly hospitalization for heart failure, with age-specific cumulative incidence and independent predictors.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hospitalizations-for-major-cardiovascular-events-in-patients-aged-75-years-or-older-with-chronic-coronary-syndrome-for-the-whole-life-span/461515/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hospitalizations-for-major-cardiovascular-events-in-patients-aged-75-years-or-older-with-chronic-coronary-syndrome-for-the-whole-life-span/461515.png","ImageObject",300,407,{"name":92,"@type":93},"Indoniesian Boy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-04","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s main objective?","Question",{"text":112,"@type":113},"To determine the cumulative incidence of lifetime hospitalizations for major cardiovascular events in patients aged 75 years or older with chronic coronary syndrome, and to identify clinical predictors.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were major cardiovascular events measured?",{"text":117,"@type":113},"Major cardiovascular events requiring admission—hospitalizations for heart failure, acute myocardial infarction, and stroke—were recorded, and cumulative incidence was calculated using death without admission as a competing event.",{"name":119,"@type":110,"acceptedAnswer":120},"Which factors independently predicted hospitalization for major cardiovascular events?",{"text":121,"@type":113},"Independent predictors included hypertension, diabetes, prior heart failure, and atrial fibrillation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},461515,1790921768,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962090760608,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Article  \nHospitalizations for Major Cardiovascular Events in Patients Aged 75 Years or Older with Chronic Coronary Syndrome for the Whole Life Span  \nLucas Barreiro Mesa 1, Martín Ruiz Ortiz 1,2,3,4, *, Josué López Baizán 1, Leticia Mateos de la Haba 1, Cristina Ogayar Luque 1, José Javier Sánchez Fernández 1, Elías Romo Peñas 1, Mónica Delgado Ortega 1,2,3, Ana Rodríguez Almodóvar 1,2,3, Fátima Esteban Martínez 1, Manuel Anguita Sánchez 1,2,3,  \nRafael González Manzanares 1,2,3, Juan Carlos Castillo Domínguez 1,2,3, José López Aguilera 1,2,3, Amador López Granados 1, Manuel Pan Álvarez-Ossorio 1,2,3 and Dolores Mesa Rubio 1,2,3  \nAcademic Editor: Michele Correale  \nReceived: 20 November 2025  \nRevised: 15 December 2025  \nAccepted: 24 December 2025  \nPublished: 27 December 2025  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Cardiology Department, Hospital Universitario Reina Sofía, University of Córdoba, 14004 Córdoba, Spain; [lucasbarme5@gmail.com](lucasbarme5@gmail.com) (L.B.M.); [josuelopezbaizan@gmail.com](josuelopezbaizan@gmail.com) (J.L.B.);  \n[leticiamateos96@gmail.com](leticiamateos96@gmail.com) (L.M.d.l.H.); [cologayar@hotmail.com](cologayar@hotmail.com) (C.O.L.); [sancfern@hotmail.com](sancfern@hotmail.com) (J.J.S.F.);  \n[eliasromo@gmail.com](eliasromo@gmail.com) (E.R.P.); [modeortega@gmail.com](modeortega@gmail.com) (M.D.O.); [anarodriguezal@yahoo.es](anarodriguezal@yahoo.es) (A.R.A.);  \n[fatimaesteban@hotmail.com](fatimaesteban@hotmail.com) (F.E.M.); [manuelanguita@secardiologia.es](manuelanguita@secardiologia.es) (M.A.S.);  \n[rafaelglezm@gmail.com](rafaelglezm@gmail.com) (R.G.M.); [jcastillod@medynet.com](jcastillod@medynet.com) (J.C.C.D.); [mircardjla@gmail.com](mircardjla@gmail.com) (J.L.A.);  \n[amadorlg@gmail.com](amadorlg@gmail.com) (A.L.G.); [manuelpanalvarez@gmail.com](manuelpanalvarez@gmail.com) (M.P.Á .-O.); [loladoctora@gmail.com](loladoctora@gmail.com) (D.M.R.)  \n2 Maimónides Biomedical Research Institute of Córdoba (IMIBIC), University of Córdoba,  \n14004 Córdoba, Spain  \n3 Cardiovascular Diseases Biomedical Research Networking Centre (CIBERCV), Carlos III Health Institute, 28029 Madrid, Spain  \n4 Faculty of Health Sciences, Isabel I International University of Castile, 09003 Burgos, Spain  \n* [Correspondence: maruor@gmail.com](Correspondence: maruor@gmail.com); Tel.: +34-957-01-03-29  \nAbstract  \nBackground/Objectives: Limited information exists on the burden of major cardiovascular morbidity in elderly patients with chronic coronary syndrome (CCS) . Our objective was to investigate the cumulative incidence of lifetime hospitalizations for major cardiovascular events (MCE) in patients aged 75 years or older with CCS and to identify clinical predictors of these events. Methods: All consecutive outpatients aged 75 years or older with CCS seen in two consultations at a tertiary hospital between 2000 and 2008 were included in a prospective study and followed until death. All MCEs requiring admission (hospitalizations for heart failure (HF), acute myocardial infarction, and stroke) were recorded, and the cumulative incidence of each event and the combination of all events was calculated, considering death without admission as a competing event. Results: A total of 414 patients were selected (mean age was 79 ± 4 years, 36% women) . After a 22-year follow-up (median 7 years, p25–75 4–11), 198 patients (48%) experienced at least one MCE, the most common being hospitalization for HF (122 patients had 209 hospitalizations) . The 10 and 20-year cumulative incidence was 41%(95% CI 36–46%) and 48%(43–53%) for any event. In multivariate analysis, independent predictors of hospitalization for MCE were hypertension (HR 1.58 [95% CI:1.15–2.18], p = 0.005), diabetes (HR 1.38 [1.03–1.85], p = 0.031), prior HF (HR 2.52 [1.59–4.01], p \u003C 0.0005), and atrial fibri","cbCaieYlGhhYAc9y","https://ap.wps.com/l/cbCaieYlGhhYAc9y","pdf",758761,15,"English","# Abstract\n# 1. Introduction","[{\"question\":\"What was the study’s main objective?\",\"answer\":\"To determine the cumulative incidence of lifetime hospitalizations for major cardiovascular events in patients aged 75 years or older with chronic coronary syndrome, and to identify clinical predictors.\"},{\"question\":\"How were major cardiovascular events measured?\",\"answer\":\"Major cardiovascular events requiring admission—hospitalizations for heart failure, acute myocardial infarction, and stroke—were recorded, and cumulative incidence was calculated using death without admission as a competing event.\"},{\"question\":\"Which factors independently predicted hospitalization for major cardiovascular events?\",\"answer\":\"Independent predictors included hypertension, diabetes, prior heart failure, and atrial fibrillation.\"}]","Hospitalizations for Major Cardiovascular Events in Patients Aged 75 Years or Older with Chronic Coronary Syndrome for the Whole Life Span | PDF",1790761771,38]