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Hormonal therapies are recommended for severe acne, treatment-resistant disease, and patients with cyclical monthly flare-ups, especially when standard options are unsuitable. The review updates hormonal pathogenesis, outlines basic endocrinal evaluation for suspected hormonal acne, and summarizes current hormonal treatment options for women.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hormonal-treatment-of-acne-vulgaris-an-update/514694/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hormonal-treatment-of-acne-vulgaris-an-update/514694.png","ImageObject",300,407,{"name":92,"@type":93},"Chumphorn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-10-06",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"When are hormonal therapies indicated for acne vulgaris?","Question",{"text":112,"@type":113},"Hormonal therapies are indicated in severe, treatment-resistant cases and in patients with monthly flare-ups, particularly when standard therapeutic options are inappropriate.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What does the article say about evaluating patients with suspected hormonal acne?",{"text":117,"@type":113},"It emphasizes endocrinal evaluation basics to better understand the hormonal milieu and guide more optimal, faster, and appropriate treatment choices.",{"name":119,"@type":110,"acceptedAnswer":120},"What key mechanisms are described in acne pathogenesis?",{"text":121,"@type":113},"The review describes acne as a follicular unit disease involving abnormal keratinization, sebum overproduction, Propionibacterium acnes biofilms, and release of proinflammatory mediators that drive inflammation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},514694,1791452916,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},2336475401981,"https://ap-avatar.wpscdn.com/avatar/22000c94efd8d5204d?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786935347598174694","Clinical, Cosmetic and Investigational Dermatology downloaded from [https://www.dovepress.com/](https://www.dovepress.com/)  \nFor personal use only.  \nClinical, Cosmetic and Investigational Dermatology Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article REVIEW  \nHormonal treatment of acne vulgaris: an update  \nMohamed L Elsaie  \nDepartment of Dermatology and Venereology, National Research Centre, Cairo, Egypt  \nCorrespondence: Mohamed L Elsaie National Research Centre, 15 Tarablos Street Off Abbas Akkad Street, Nasr city 11371, Cairo, Egypt  \nTel +20 10 9950 1169  \nEmail [Egydoc77@yahoo.com](Egydoc77@yahoo.com)  \nThis article was published in the following Dove Press journal: Clinical, Cosmetic and Investigational Dermatology  \n2 September 2016  \nNumber of times this article has been viewed  \nAbstract: Acne vulgaris is a common skin condition associated with multiple factors. Although mostly presenting alone, it can likewise present with features of hyperandrogenism and hormonal discrepancies. Of note, hormonal therapies are indicated in severe, resistant-to-treatment cases and in those with monthly flare-ups and when standard therapeutic options are inappropriate. This article serves as an update to hormonal pathogenesis of acne, discusses the basics of endocrinal evaluation for patients with suspected hormonal acne, and provides an overview of the current hormonal treatment options in women.  \nKeywords: acne, hormones, hyperandrogenism  \nIntroduction  \nAcne vulgaris affects ~80% of adolescents and young adults aged 11–30 years. The majority of affected individuals remit before the third decade of age, leaving the rest with an unpredictable course throughout their lives.1 The principal hallmarks of acne include follicular hyperproliferation and plugging, extensive formation of sebum, activity of Propionibacterium acnes, and inflammation.2 Standardization of acne treatments is impossible with the huge amount of data and research being released constantly.3 Hormonal therapies are reserved not only for patients with biochemical markers of hyperandrogenism but also for the severe, resistant cases as well as for those patients who show an unpredictable course and high frequency of acne bouts without hyperandrogenemia.4 A decent comprehension of the hormonal milieu in the human body can pinpoint toward an optimal, faster, and more appropriate treatment of acne.  \nAcne pathogenesis  \nAcne is a follicular unit disease. It involves pathologically overproduction of serum, abnormal follicular keratinization, formation of P. acnes biofilms and colonies, and finally the release of proinflammatory mediators to the skin.5  \nWhile the formation of the microcomedones is the first symptom of acne, the exact reason for triggering such reaction remains unknown.6 Acne-prone individuals have larger sized sebaceous glands that are stimulated at the time of puberty.7 Dihydrotestosterone (DHT) was shown to be more selective to sebocytes ofthe face but not the leg. This determines the predilection of acne lesions to certain areas on the body.8 Several pathways and hormones beside androgens regulate the activity of sebocytes, for example, peroxisome proliferator-activated receptors, substance P receptors,  \n[submit your manuscript](submit your manuscript | www.dovepress.com)[ | www.dovepress.com](submit your manuscript | www.dovepress.com)[ ](submit your manuscript | www.dovepress.com)Dovepress      \n[http:](http://dx.doi.org/10.2147/CCID.S114830)[//dx.doi.org/10.2147/CCID.S114830](http://dx.doi.org/10.2147/CCID.S114830)  \nClinical, Cosmetic and Investigational Dermatology 2016:9 241–248 241  \n© 2016 Elsaie. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at [https://www.dovepress.com/terms](https://www.dovepress.com/terms).  \nphp and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ([http://creativecommons.org/l","cbCaidTWO1YvSG39","https://ap.wps.com/l/cbCaidTWO1YvSG39","pdf",328196,"English","# Introduction\n# Acne pathogenesis\n## Hormones implicated in acne pathogenesis\n### Androgens","[{\"question\":\"When are hormonal therapies indicated for acne vulgaris?\",\"answer\":\"Hormonal therapies are indicated in severe, treatment-resistant cases and in patients with monthly flare-ups, particularly when standard therapeutic options are inappropriate.\"},{\"question\":\"What does the article say about evaluating patients with suspected hormonal acne?\",\"answer\":\"It emphasizes endocrinal evaluation basics to better understand the hormonal milieu and guide more optimal, faster, and appropriate treatment choices.\"},{\"question\":\"What key mechanisms are described in acne pathogenesis?\",\"answer\":\"The review describes acne as a follicular unit disease involving abnormal keratinization, sebum overproduction, Propionibacterium acnes biofilms, and release of proinflammatory mediators that drive inflammation.\"}]","Hormonal treatment of acne vulgaris: an update | PDF",1791301367]