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The 9-week randomized controlled trial recruits 30 participants under 70 in Chile’s Metropolitan Region. Participants receive either an Aurora experimental kit with equipment and a structured logbook, or an Aurora control kit with basic materials. Outcomes assess quality of life via questionnaires and patient journals, with emotional effects from thematic analysis and interviews; secondary measures include functional capacity tests and biological markers such as lipids, inflammation, and tumor progression.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/home-based-patient-centered-physical-activity-program-for-quality-of-life-preservation-during-neoadjuvant-chemotherapy-in-breast-cancer-the-aurora-randomized-controlled-trial-protocol/457678/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/home-based-patient-centered-physical-activity-program-for-quality-of-life-preservation-during-neoadjuvant-chemotherapy-in-breast-cancer-the-aurora-randomized-controlled-trial-protocol/457678.png","ImageObject",300,407,{"name":92,"@type":93},"Indoniesian Boy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-07","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the AURORA trial evaluating?","Question",{"text":112,"@type":113},"The AURORA trial evaluates the effects of a home-based patient-centered physical activity program on quality of life and related primary and secondary outcomes compared with standard care during neoadjuvant chemotherapy in breast cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How are participants assigned and what do they receive?",{"text":117,"@type":113},"Participants are randomized 1:1 to either the 9-week Aurora experimental program, which includes an experimental kit with exercise equipment and a designed logbook, or the Aurora control program, which includes a control kit with a notebook and basic materials.",{"name":119,"@type":110,"acceptedAnswer":120},"What outcomes are measured in the study?",{"text":121,"@type":113},"Quality of life is assessed using questionnaires and patient perceptions, supported by thematic analysis of patient-recorded journals and in-depth group interviews. Secondary outcomes include functional capacity tests and biological markers such as lipid profiling, inflammation biomarkers, and tumor progression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},457678,1791345396,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},962090760608,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Montt‑Blanchard et al. Trials (2025) 27:12 [https://doi.org/10.1](https://doi.org/10.1) 186/s13063‑025‑09301‑y  \nTrials  \n STUDY PROTOCOL Open Access  \nHome‑based patient‑centered physical  \nactivity program for quality of life preservation during neoadjuvant chemotherapy in breast cancer: the AURORA randomized controlled trial protocol  \nDenise Montt-Blanchard1,2,3* , Karol Ramírez-Parada3,4 and Viviana Montecinos 1,3  \nAbstract  \nBackground Despite the known benefits of physical activity for women with breast cancer (BC), adherence to recommended guidelines remains low, especially during neo-adjuvant chemotherapy. The Aurora intervention presentsa multidimensional approach to improve physical activity adherence, considering the patient’s emotional and physical needs and barriers to physical activity. This protocol aims to evaluate Aurora’s effects compared to standard care in BC patients.  \nMethods In this 9-week randomized controlled trial, 30 female BC patients under 70 years of age, undergoing neo-adjuvant chemotherapy in the Metropolitan Region of Chile, will be recruited. Participants will receive a standard online education class on the benefits of physical activity for BC patients, which includes general information on the importance of exercise during treatment, recommended physical activity guidelines, and tips for safely incorporating movement into daily routines. Afterward, participants will be randomly allocated in a 1:1 ratio to either the 9-week Aurora experimental program (Aurora experimental kit: branded box containing exercise equipment, designed logbook journal, hydration bottle, exercise leaflet, and arm volume measurement tape) or the Aurora control program (Aurora control kit: branded tote bag containing a blank notebook, hydration bottle, and exercise leaflet) . The study will employ a mixed-methods approach to assess multidimensional treatment effects through baseline and post-intervention measurements. The primary outcome will be quality of life, which will be assessed using questionnaires and patient perceptions, with thematic analysis of patient-recorded journals and in-depth group interviews to evaluate emotional treatment effects. Secondary outcomes will include (1) functional capacity tests to measure adverse physical effects and (2) biological markers assessed through lipid profiling, inflammation biomarkers, and tumor progression.  \nDiscussion Our conceptual hypothesis is that the Aurora intervention program will positively impact pri  \nmary and secondary outcomes compared to the control group. Integrating the behavior change COM-B model and a patient-centered design facilitates tailoring interventions to BC patients’ multidimensional needs and barriers.  \n*Correspondence: Denise Montt-Blanchard [denisemontt@uc.cl](denisemontt@uc.cl)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2025, modified publication 2026. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses","cbCairiYDoWMjgc3","https://ap.wps.com/l/cbCairiYDoWMjgc3","pdf",1375842,16,"English","# Background\n## Physical activity benefits and adherence barriers\n# Methods\n## Trial design and participants\n## Intervention and control programs\n## Outcome measures\n# Discussion\n## Behavior change framework and expected effects\n# Trial registration","[{\"question\":\"What is the AURORA trial evaluating?\",\"answer\":\"The AURORA trial evaluates the effects of a home-based patient-centered physical activity program on quality of life and related primary and secondary outcomes compared with standard care during neoadjuvant chemotherapy in breast cancer.\"},{\"question\":\"How are participants assigned and what do they receive?\",\"answer\":\"Participants are randomized 1:1 to either the 9-week Aurora experimental program, which includes an experimental kit with exercise equipment and a designed logbook, or the Aurora control program, which includes a control kit with a notebook and basic materials.\"},{\"question\":\"What outcomes are measured in the study?\",\"answer\":\"Quality of life is assessed using questionnaires and patient perceptions, supported by thematic analysis of patient-recorded journals and in-depth group interviews. Secondary outcomes include functional capacity tests and biological markers such as lipid profiling, inflammation biomarkers, and tumor progression.\"}]","Home-based patient-centered physical activity program for quality of life preservation during neoadjuvant chemotherapy in breast cancer: the AURORA randomized controlled trial protocol | PDF",1790750122]