[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-436190-105":59,"doc-detail-436190-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","hla-dr-genotypes-in-patients-with-systemic-lupus-erythematosus-in-taiwan","HLA-DR genotypes in patients with systemic lupus erythematosus in Taiwan","","Study assesses how distinct HLA-DR genotypes influence systemic lupus erythematosus (SLE) incidence in Taiwanese patients and whether risk alleles relate to clinical manifestations and age at disease onset. A cohort of 234 SLE patients and 346 healthy controls underwent HLA-DR genotyping using the HLA FluoGene DRDQ kit. Statistical testing used chi-square and t tests. Results identify HLA-DR2 as a susceptibility marker with earlier onset and more severe manifestations, including higher frequencies of oral ulcers and renal involvement.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hla-dr-genotypes-in-patients-with-systemic-lupus-erythematosus-in-taiwan/436190/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hla-dr-genotypes-in-patients-with-systemic-lupus-erythematosus-in-taiwan/436190.png","ImageObject",300,407,{"name":92,"@type":93},"Miles","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study investigating about HLA-DR genotypes in Taiwanese patients with SLE?","Question",{"text":112,"@type":113},"The study investigated how different HLA-DR genotypes affect SLE incidence in Taiwanese patients and whether risk alleles associate with clinical manifestations and age of disease onset.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many participants were included and how was HLA-DR genotyping performed?",{"text":117,"@type":113},"The study enrolled 234 SLE patients and 346 healthy controls. HLA-DR genotyping was performed using the HLA FluoGene DRDQ kit for each subject.",{"name":119,"@type":110,"acceptedAnswer":120},"Which HLA-DR genotype showed the strongest association with SLE in this population?",{"text":121,"@type":113},"HLA-DR2 was significantly more frequent in SLE patients than in controls, with an odds ratio of 2.05 and p \u003C 0.001.",{"name":123,"@type":110,"acceptedAnswer":124},"Did HLA-DR2 relate to clinical severity and age of onset?",{"text":125,"@type":113},"Yes. HLA-DR2 patients had earlier disease onset and higher prevalence of oral ulcer, avascular necrosis of bone, and renal involvement, including lupus nephritis.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},436190,1790763919,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":148},13056703019404,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","J Chin MedAssoc  \nOriginal article  \nHLA-DR genotypes in patients with systemic lupus erythematosus in Taiwan  \nChang-Yi Yena,b, Pin-Yi Wanga,c, Kuan-Yu Chena,c, Chia-Chun Tsenga,d, Cheng-Chin Wua, Tsan-Teng Oua, Jeng-Hsien Yena,c,e,f,*  \naDivision of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; bInstitute of Medical Informatics, College of Electrical Engineering and Computer Science, National Cheng Kung University, Tainan, Taiwan, ROC; cGraduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; dSchool of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; eInstitute of Biomedical Science, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC; fDepartment of Biomedical Science and Technology, National Yang Ming Chiao Tung University, Hsinchu, Taiwan, ROC  \nAbstract  \nBackground: Different human leukocyte antigen (HLA)-DR genotypes have been known to be associated with the risk of development of systemic lupus erythematosus (SLE) in different populations, although Lu et al. have reported previously that no correlation exists between the HLA-DR genotype and disease manifestation in SLE patients in Taiwan. We investigated the effects different HLA-DR genotypes had on SLE incidence in Taiwanese patients as to whether risk alleles were associated with different clinical manifestations, and the effects risk alleles had on the age of disease onset.  \nMethods: Two hundred thirty-four SLE patients and 346 healthy controls were enrolled. HLA-DR genotyping was performed with the HLA FluoGene DRDQ kit for each subject. Chi-square tests and t tests were performed for statistical analysis.  \nResults: HLA-DR2 was significantly more frequently found in SLE patients than in controls (odds ratio [OR] = 2.05, 95% CI, 1.44- 2.92, p \u003C 0 .001) . Notably, HLA-DR6 appeared to trend toward negative correlation with SLE, whereas HLA-DR8 appeared to trend toward positive correlation. HLA-DR2 patients had an earlier onset of disease as well as a higher prevalence of oral ulcer, avascular necrosis of bone, and renal involvement (lupus nephritis) .  \nConclusion: HLA-DR2 was associated with SLE susceptibility in this Taiwanese population as well as lower age of disease onset and more severe clinical manifestations.  \nKeywords: Alleles; Genotypes; Human leukocyte antigen; Lupus nephritis; Systemic lupus erythematosus  \n1. INTRODUCTION  \nSystemic lupus erythematosus (SLE) is a complex, multifaceted autoimmune disease that can present as fever, skin rashes, fatigue, and pain or swelling of the joints; it is associated with the production of autoantibodies, and is known to be associated with both environmental and genetic factors. Some of these environmental factors include infection as well as exposure to cigarette smoke, ultraviolet light, and certain chemicals and medications,1–4 whereas genetic factors include a family history of SLE.5,6  \nOver the past several decades, numerous loci across the human genome have been identified as being associated with SLE. Genetic loci located on chromosome 1 play important  \n* Address correspondence. Dr. Jeng-Hsien Yen, Division of Rheumatology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Ziyou 1st Road, Kaohsiung 807, Taiwan, [ROC. E-mail address: jehsye@kmu.edu](ROC. E-mail address: jehsye@kmu.edu). tw (J.-H. Yen).  \nConflicts of interest: The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2023) 86: 1060-1065.  \nReceived March 28, 2023; accepted September 9, 2023. doi: 10. 1097/JCMA.0000000000001009  \nCopyright © 2023, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.","cbCailol01P7G2Nk","https://ap.wps.com/l/cbCailol01P7G2Nk","pdf",471345,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What was the study investigating about HLA-DR genotypes in Taiwanese patients with SLE?\",\"answer\":\"The study investigated how different HLA-DR genotypes affect SLE incidence in Taiwanese patients and whether risk alleles associate with clinical manifestations and age of disease onset.\"},{\"question\":\"How many participants were included and how was HLA-DR genotyping performed?\",\"answer\":\"The study enrolled 234 SLE patients and 346 healthy controls. HLA-DR genotyping was performed using the HLA FluoGene DRDQ kit for each subject.\"},{\"question\":\"Which HLA-DR genotype showed the strongest association with SLE in this population?\",\"answer\":\"HLA-DR2 was significantly more frequent in SLE patients than in controls, with an odds ratio of 2.05 and p \\u003c 0.001.\"},{\"question\":\"Did HLA-DR2 relate to clinical severity and age of onset?\",\"answer\":\"Yes. HLA-DR2 patients had earlier disease onset and higher prevalence of oral ulcer, avascular necrosis of bone, and renal involvement, including lupus nephritis.\"}]","HLA-DR genotypes in patients with systemic lupus erythematosus in Taiwan | PDF",1790677087,15]