[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-400710-105":59,"doc-detail-400710-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","hiv-pre-exposure-prophylaxis-clinical-care-and-updates","HIV Pre-Exposure Prophylaxis - Clinical Care and Updates","","This document provides a comprehensive clinical overview and educational update on HIV Pre-Exposure Prophylaxis (PrEP). It details the clinical evidence supporting PrEP efficacy, emphasizing the strong correlation between medication adherence—measured by detectable drug levels—and clinical effectiveness. The material reviews current pharmacological options, including oral regimens like TDF/FTC and TAF/FTC, as well as injectable options such as Cabotegravir. Designed for healthcare professionals, it also covers HIV prevention strategies, clinical considerations for prescribing, and quality improvement measures to enhance implementation within clinical practice settings, drawing on data from major clinical trials.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/hiv-pre-exposure-prophylaxis-clinical-care-and-updates/400710/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/hiv-pre-exposure-prophylaxis-clinical-care-and-updates/400710.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-27",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the relationship between PrEP adherence and effectiveness?","Question",{"text":112,"@type":113},"The document illustrates that PrEP effectiveness is directly tied to adherence; higher percentages of participant samples with detectable drug levels correlate with significantly higher rates of HIV prevention effectiveness.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What are the primary medications currently used for PrEP?",{"text":117,"@type":113},"Current options include oral regimens such as TDF/FTC (Truvada/Generic) and TAF/FTC (Descovy), as well as the injectable medication Cabotegravir (CAB-LA/Apretude).",{"name":119,"@type":110,"acceptedAnswer":120},"What are the core objectives for clinicians learning about PrEP?",{"text":121,"@type":113},"The objectives include describing evidence for PrEP, listing clinical considerations for various delivery forms, applying lessons from trials to clinical settings, and incorporating quality improvement measures to boost implementation.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},400710,1790648956,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","HIV Pre-Exposure Prophylaxis (PrEP) Clinical Care and Updates  \nShanna Dell, MPH, RN, ACRN Senior Clinical Nurse for HIV Prevention Division of Infectious Diseases Johns Hopkins Bayview Johns Hopkins University School of Medicine  \nDisclosures  \n• None  \n   MidAtlantic AIDS Education and Training Center   \nObjectives  \n• Describe the evidence for HIV PrEP  \n• List clinical considerations for oral and injectable PrEP medications  \n• Apply lessons learned to clinical work settings  \n• Incorporate quality improvement measures to increase PrEP implementation  \nMidAtlantic AIDS Education and Training Center   \nPrEP-Evidence For Prescribing  \n   MidAtlantic AIDS Education and Training Center   \nDisparities in Newly Diagnosed HIV Infections  \nin U.S.  \nMidAtlantic AIDS Education and Training Center   \nSource: NYC Department of Health and Mental Hygiene  \n   MidAtlantic AIDS Education and Training Center   \nHIV Prevention Tools  \n• Condoms  \n• Syringe exchange  \n• Safe blood supply  \n• STI diagnosis and treatment  \n• pMTCT  \n• HIV testing, linkage to care, and U=U  \n•  PrEP  \n• PEP  \nMidAtlantic AIDS Education and Training Center   \nMedications Currently Used for PrEP  \n\n| Drug name | Abbreviation | Form, Meds (Brand Name) |\n| --- | --- | --- |\n| tenofovir alafenamide | TAF | Oral TAF/FTC (Descovy) Oral TDF/FTC (Truvada, Generic) |\n| tenofovir disoproxil fumarate | TDF |  |\n| emtricitabine | FTC |  |\n| Cabotegravir | CAB | Injectable, CAB-LA (Apretude) |\n\n   MidAtlantic AIDS Education and Training Center   \nHIV Lifecycle & Major Classes of HIV Medications  \nNRTI (oral)  \nNucleoside reverse transcriptase inhibitor  \nNNRTI  \nNon-nucleoside reverse transcriptase inhibitor  \nPI  \nProtease inhibitor  \nINSTI (injectable)  \nIntegrase inhibitor  \nMidAtlantic AIDS Education and Training Center   \nOral PrEP Works...If You Take It  \n[https://www.avac.org](https://www.avac.org)  \n  MidAtlantic AIDS Education and Training Center","cbCaissSrZtiZN9h","https://ap.wps.com/l/cbCaissSrZtiZN9h","pdf",2332239,64,"English","# Evidence for HIV PrEP\n## Clinical Considerations for Medications\n## Quality Improvement in PrEP Implementation","[{\"question\":\"What is the relationship between PrEP adherence and effectiveness?\",\"answer\":\"The document illustrates that PrEP effectiveness is directly tied to adherence; higher percentages of participant samples with detectable drug levels correlate with significantly higher rates of HIV prevention effectiveness.\"},{\"question\":\"What are the primary medications currently used for PrEP?\",\"answer\":\"Current options include oral regimens such as TDF/FTC (Truvada/Generic) and TAF/FTC (Descovy), as well as the injectable medication Cabotegravir (CAB-LA/Apretude).\"},{\"question\":\"What are the core objectives for clinicians learning about PrEP?\",\"answer\":\"The objectives include describing evidence for PrEP, listing clinical considerations for various delivery forms, applying lessons from trials to clinical settings, and incorporating quality improvement measures to boost implementation.\"}]","HIV Pre-Exposure Prophylaxis - Clinical Care and Updates | PDF",1790513385,161]