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Additional stains assessed c-MET, p16, c-Myc, Ki-67, p53, and STING to explore pathogenetic pathways and potential targeted-therapy candidates.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/histopathologic-classification-and-immunohistochemical-features-of-papillary-renal-neoplasm-with-potential-therapeutic-targets/340461/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/histopathologic-classification-and-immunohistochemical-features-of-papillary-renal-neoplasm-with-potential-therapeutic-targets/340461.png","ImageObject",300,407,{"name":42,"@type":43},"Seraphina","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-25","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the main objective of the study?","Question",{"text":63,"@type":64},"To evaluate immunohistochemical features of papillary renal neoplasms and identify possible therapeutic targets that could support more precise patient care.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were papillary renal neoplasms evaluated in the study?",{"text":68,"@type":64},"The study collected 140 cases from three hospitals and performed immunohistochemical studies on tissue microarray slides, including markers used for differential diagnosis and markers linked to signaling and potential targeting.",{"name":70,"@type":61,"acceptedAnswer":71},"Which immunohistochemical findings suggested potential targeted-therapy candidates?",{"text":72,"@type":64},"Subsets of cases showed c-MET, p16, c-MYC, and STING expression, and some were associated with increased Ki-67 proliferation index, supporting their possible value as targeted-therapy candidates.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},340461,1790110248,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":123,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},962075114101,"https://ap-avatar.wpscdn.com/avatar/e000253a75eb197efd?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780044092746381165","Journal of Pathology and Translational Medicine 2024; 58: 321-330  \n[https://doi.org/10.4132/jptm.2024.07.31](https://doi.org/10.4132/jptm.2024.07.31) ORIGINAL ARTICLE  \nHistopathologic classification and immunohistochemical features of papillary renal neoplasm with potential therapeutic targets  \nJeong Hwan Park1,2, Su-Jin Shin3, Hyun-Jung Kim4, Sohee Oh5, Yong Mee Cho6  \n1Department of Pathology, Seoul National University College of Medicine, Seoul;  \n2Department of Pathology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul;  \n3Department of Pathology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul;  \n4Department of Pathology, Inje University Sanggye Paik Hospital, Seoul;  \n5Medical Research Collaborating Center, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul; 6Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea  \nBackground: Papillary renal cell carcinoma (pRCC) is the second most common histological subtype of renal cell carcinoma and is considered a morphologically and molecularly heterogeneous tumor. Accurate classification and assessment of the immunohistochemical features of possible therapeutic targets are needed for precise patient care. We aimed to evaluate immunohistochemical features and possible therapeutic targets of papillary renal neoplasms Methods: We collected 140 papillary renal neoplasms from three different hospitals and conducted immunohistochemical studies on tissue microarray slides. We performed succinate dehydrogenase B, fumarate hydratase, and transcription factor E3 immunohistochemical studies for differential diagnosis and re-classified five cases (3.6%) of papillary renal neoplasms. In addition, we conducted c-MET, p16, c-Myc, Ki-67, p53, and stimulator of interferon genes (STING) immunohistochemical studies to evaluate their pathogenesis and value for therapeutic targets. Results: We found that c-MET expression was more common in pRCC (classic) (p = .021) among papillary renal neoplasms and Ki-67 proliferation index was higher in pRCC (not otherwise specified, NOS) compared to that of pRCC (classic) and papillary neoplasm with reverse polarity (marginal significance, p = .080). Small subsets of cases with p16 block positivity (4.5%) (pRCC [NOS] only) and c-Myc expression (7.1%) (pRCC [classic] only) were found. Also, there were some cases showing STING expression and those cases were associated with increased Ki-67 proliferation index (marginal significance, p = .063). Conclusions: Our findings suggested that there are subsets of pRCC with c-MET, p16, c-MYC, and STING expression and those cases could be potential candidates for targeted therapy.  \nKey Words: Renal cell carcinoma; Immunohistochemistry; Proto-oncogene proteins c-met; STING1 protein  \nReceived: January 26, 2024 Revised: July 25, 2024 Accepted: July 31, 2024  \nCorresponding Author: Yong Mee Cho, MD, PhD, Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea  \nTel: +82-2-3010-5965, Fax: +82-2-3010-7898, [E-mail: yongcho@amc.seoul.kr](E-mail: yongcho@amc.seoul.kr)  \nKidney cancer is one of the most lethal genitourinary tumors worldwide with an incidence and mortality rate of approximately 2% among all cancers [1]. Kidney cancer is the seventh and tenth most common cancer in men and women, respectively [2], and accounts for the 16th most common cause of cancer-related deaths worldwide [3]. The 5-year survival rate of patients with kidney cancer is approximately 70% for stage I–II, 30%–55% for stage III, and 5% for stage IV [4]. Kidney cancer can spread to various organs including the lungs, lymph nodes, and bones [5]. Histologically, kidney cancer is classified into approximately 20 histologic subtypes, including clear cell renal cell carcinoma  \n(ccRCC), papillary renal cell carcinoma (pRCC), and chromo","cbCaiqXyMbnkf71G","https://ap.wps.com/l/cbCaiqXyMbnkf71G","pdf",2079703,"English","# Background and Aim\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What was the main objective of the study?\",\"answer\":\"To evaluate immunohistochemical features of papillary renal neoplasms and identify possible therapeutic targets that could support more precise patient care.\"},{\"question\":\"How were papillary renal neoplasms evaluated in the study?\",\"answer\":\"The study collected 140 cases from three hospitals and performed immunohistochemical studies on tissue microarray slides, including markers used for differential diagnosis and markers linked to signaling and potential targeting.\"},{\"question\":\"Which immunohistochemical findings suggested potential targeted-therapy candidates?\",\"answer\":\"Subsets of cases showed c-MET, p16, c-MYC, and STING expression, and some were associated with increased Ki-67 proliferation index, supporting their possible value as targeted-therapy candidates.\"}]","Histopathologic classification and immunohistochemical features of papillary renal neoplasm with potential therapeutic targets | PDF",1790036690,25]