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A cross-sectional study includes 120 patients and 120 healthy volunteers, comparing relative circulating expression before treatment. MicroRNA-221 is higher, while microRNA-451 is lower in carcinoma patients, especially when extracapsular invasion, lymphatic metastasis, and poor prognosis are present. Multivariate logistic regression links aggressive morphological features with microRNA-221 high and microRNA-451 low.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/higher-microrna-221-and-lower-microrna-451-expression-are-associated-with-poor-prognosis-in-patients-with-thyroid-papillary-carcinoma/332479/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/higher-microrna-221-and-lower-microrna-451-expression-are-associated-with-poor-prognosis-in-patients-with-thyroid-papillary-carcinoma/332479.png","ImageObject",300,407,{"name":92,"@type":93},"Levi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What relationship does the study assess between microRNAs and prognosis?","Question",{"text":112,"@type":113},"The study analyzes how serum microRNA-221 and microRNA-451 expression relates to pathological features and prognosis in patients with thyroid papillary carcinoma.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were microRNA levels measured and compared?",{"text":117,"@type":113},"Relative expression levels of microRNA-221 and microRNA-451 were compared between the thyroid papillary carcinoma group (before treatment) and healthy controls, and also across pathological characteristics.",{"name":119,"@type":110,"acceptedAnswer":120},"Which microRNA pattern is linked with aggressive features and poor prognosis?",{"text":121,"@type":113},"Higher microRNA-221 expression and lower microRNA-451 expression are associated with extracapsular invasion, lymphatic metastasis, and poor prognosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332479,1790097545,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},7971461740909,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","DEL SISTEMA SANITARIO DE NAVARRA  \nAn Sist Sanit Navar 2023; 47(2): e1086 [https://doi.org/10.23938/ASSN.1086](https://doi.org/10.23938/ASSN.1086)  \neISSN: 2340-3527 • ISSN: 1137-6627  \n[https://recyt.fecyt.es/index.php/ASSN/](https://recyt.fecyt.es/index.php/ASSN/)  \nORIGINAL ARTICLES  \nHigher microRNA-221 and lower microRNA-451 expression are associated with poor prognosis in patients with thyroid papillary carcinoma La expresión aumentada de microRNA-221 y disminuida de microRNA-451 serelaciona con mal pronóstico en pacientes con carcinoma papilar de tiroides  \nJiawei Wu, Weimin Sun, Jingyao Shen, Liping Hu  \n\n| ABSTRACT | RESUMEN |\n| --- | --- |\n| Background. To analyze the relationship between serum mi- | Fundamento. Analizar la relación entre la expresión sérica |\n| croRNA-221 and microRNA-451 relative expression and the | relativa de microRNA-221 y microRNA-451 y las características |\n| pathological features and prognosis of patients with thyroid | patológicas y el pronóstico de pacientes con carcinoma papilar |\n| papillary carcinoma. | de tiroides. |\n| Methods. Cross-sectional study that included 120 patients with | Metodología. Estudio transversal que incluyó 120 pacientes |\n| papillary thyroid cancer treated at the hospital and 120 healthy | con carcinoma papilar de tiroides tratados en el hospital y 120 |\n| volunteers selected as the control group who underwent physical | voluntarios sanos que se sometieron a un examen físico en el |\n| examination at the same centre. The relative expression levels of | mismo centro (grupo control). Los niveles de expresión relati- |\n| microRNA-221 and microRNA-451 were compared between the | va de microRNA-221 y microRNA-451 se compararon entre el |\n| thyroid papillary carcinoma group (prior to treatment) and the control group. Additionally, microRNA-221 and microRNA-451 | grupo con carcinoma papilar de tiroides (previo al inicio del tratamiento) y el grupo control, así como entre pacientes con |\n| expression levels were analyzed in patients with papillary thy- | diferentes características patológicas. |\n| roid carcinoma across different pathological characteristics. | Resultados. Los niveles de microRNA-221 estaban más ele- |\n| Results. Serum microRNA-221 relative levels were significant- | vados (p\u003C0,001) en el grupo con carcinoma papilar de tiroi- |\n| ly higher (p\u003C0.001) in the papillary carcinoma group compared | des, mientras los niveles de microRNA-451 fueron mayores |\n| to the control group, while microRNA-451 levels were higher in | en el grupo control (p\u003C0,001). Los niveles de microRNA-221 |\n| the control group (p\u003C0.001). In the papillary carcinoma group, | eran más altos en pacientes con carcinoma papilar de tiroi- |\n| microRNA-221 expression was significantly higher inpatients with | des con invasión extracapsular (p\u003C0,001), metástasis linfáti- |\n| extracapsular invasion (p\u003C0.001), lymphatic metastasis (p=0.003), | cas (p=0,003) y mal pronóstico (p\u003C0,001). Los niveles de mi- |\n| and poor prognosis (p\u003C0.001). Conversely, microRNA-451 expres- | croRNA-451 fueron significativamente menores (p\u003C0,001) en |\n| sion was significantly lower (p\u003C0.001) in patients with extracap- | pacientes con invasión extracapsular, metástasis linfáticas |\n| sular invasion, lymphatic metastasis, and poor prognosis. In the | y mal pronóstico. Tanto la invasión extracapsular como las |\n| multivariate logistic regression analysis, morphological features | metástasis linfáticas, características sugestivas de un com- |\n| suggestive of an aggressive clinical behavior (extracapsular invasion and lymphatic metastasis) were related to high expression of | portamiento clínico agresivo, se asociaron a alta expresiónde microRNA-221 y a baja expresión de microRNA-451 en pa- |\n| microRNA-221 and low expression of microRNA-451 in patients with thyroid papillary carcinoma (p\u003C0.001). | cientes con carcinoma papilar de tiroides (regresión logísticamúltiple; p\u003C0,001). |\n| Conclusions. Serum microRNA-221 and microRNA","cbCaidSBd2yc5t8N","https://ap.wps.com/l/cbCaidSBd2yc5t8N","pdf",179168,"English","# Abstract\n# Background\n# Methods\n# Results\n# Conclusions\n# Keywords\n# Introduction\n# Materials and Methods\n# Results","[{\"question\":\"What relationship does the study assess between microRNAs and prognosis?\",\"answer\":\"The study analyzes how serum microRNA-221 and microRNA-451 expression relates to pathological features and prognosis in patients with thyroid papillary carcinoma.\"},{\"question\":\"How were microRNA levels measured and compared?\",\"answer\":\"Relative expression levels of microRNA-221 and microRNA-451 were compared between the thyroid papillary carcinoma group (before treatment) and healthy controls, and also across pathological characteristics.\"},{\"question\":\"Which microRNA pattern is linked with aggressive features and poor prognosis?\",\"answer\":\"Higher microRNA-221 expression and lower microRNA-451 expression are associated with extracapsular invasion, lymphatic metastasis, and poor prognosis.\"}]","Higher microRNA-221 and lower microRNA-451 expression are associated with poor prognosis in patients with thyroid papillary carcinoma | PDF",1789998405,18]