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This longitudinal study examined whether the muscle-to-fat ratio relates to the 3-year decline in handgrip strength among community-dwelling adults aged 50 years and older, using two assessment waves from the Longitudinal Aging Study of Taipei. The findings indicate that a higher muscle-to-fat ratio, greater physical activity, and better glycemic control are associated with reduced risk of rapid decline.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/high-muscle-to-fat-ratio-predicts-slow-muscle-strength-decline-in-middle-aged-and-older-adults-longitudinal-aging-study-of-taipei/433651/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/high-muscle-to-fat-ratio-predicts-slow-muscle-strength-decline-in-middle-aged-and-older-adults-longitudinal-aging-study-of-taipei/433651.png","ImageObject",300,407,{"name":92,"@type":93},"Lucas Martin","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the purpose of this study?","Question",{"text":112,"@type":113},"To examine the relationship between the muscle-to-fat ratio and 3-year decrease in handgrip strength in community-dwelling adults aged 50 years and older.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the muscle-to-fat ratio measured?",{"text":117,"@type":113},"Appendicular skeletal muscle mass was measured using bioimpedance analysis, then divided by total body fat to derive the muscle-to-fat ratio.",{"name":119,"@type":110,"acceptedAnswer":120},"What factors were associated with a lower risk of rapid handgrip strength decline?",{"text":121,"@type":113},"A greater muscle-to-fat ratio, greater physical activity, and lower glycated hemoglobin (HbA1c) were associated with reduced risk of rapid decline.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},433651,1791087689,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","J Chin MedAssoc  \nOriginal article  \nHigh muscle-to-fat ratio predicts slow muscle strength decline in middle-aged and older adults:  \nLongitudinal aging study of Taipei  \nChing-Jen Changa, Ming-Hsien Linb,c, Liang-Yu Chenb,c, Sung-Hua Tsengb,c, An-Chun Hwangb,c, Chung-Yu Huangb,c, Ko-Han Yenb,c, Liang-Kung Chenb,c,d, Li-Ning Pengb,c,*  \naDepartment of Family Medicine, Feng-Yuan Hospital, Ministry of Health and Welfare, Taiwan, Taipei, Taiwan, ROC; bCenter for Geriatrics and Gerontology, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; cCenter for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; dTaipei Municipal Gan-Dau Hospital (Managed by Taipei Veterans General Hospital), Taipei, Taiwan, ROC  \nAbstract  \nBackground: Handgrip strength is a vital marker of muscle function and predictor of health outcomes in older adults. This study investigated the relationship between the muscle-to-fat ratio and 3-year decrease in handgrip strength in community-dwelling adults aged ≥50 years.  \nMethods: Data were obtained from the Longitudinal Aging Study of Taipei (LAST), a cohort study of adults aged 50 years and older. Measurements from two waves, 3 years apart, were analyzed. Demographics, laboratory data, and handgrip strength data were collected. Appendicular skeletal muscle mass was assessed using bioimpedance analysis, and the relative appendicular skeletal muscle mass index was calculated by dividing appendicular muscle mass by height squared. The muscle-to-fat ratio was derived by dividing appendicular muscle mass by total body fat. Handgrip strength decrease was divided into quartiles; slow decliners experienced the smallest decrease, whereas rapid decliners had the greatest decrease. Associations between the muscle-to-fat ratio and other risk factors were analyzed.  \nResults: Over 3 years, the Charlson Comorbidity Index, medication use, waist-to-hip ratio, and fat percentage increased, whereas skeletal muscle mass, the muscle-to-fat ratio, and handgrip strength decreased. Rapid decliners were less likely to be male (21 .6% vs 33.3%, p = 0 .008) or alcohol drinkers (53 .8% vs 66.2%, p = 0 .01) and had lower skeletal muscle mass (6 .3 ± 0.9 vs 6.6 ± 1.0, p = 0.006) and muscle-to-fat ratios (1 .0 ± 0.4 vs 1.1 ± 0.5, p = 0.004) but greater fat percentages (30 .4 ± 6.6 vs 29.0 ± 7.6, p = 0.045) . A greater muscle-to-fat ratio (odds ratio [OR] = 3 .751, p = 0 .047), greater physical activity (OR = 1.694, p = 0 .04), and lower glycated hemoglobin (HbA1c; OR = 0.61, p = 0.008) reduced the risk of rapid decline.  \nConclusion: The muscle-to-fat ratio, together with physical activity and glycemic control, predicts a decrease in handgrip strength, highlighting its potential as a biomarker of intrinsic capacity and muscle–fat interplay. Further research is needed to explore the underlying biological mechanisms involved.  \nKeywords: Glycemic level; Handgrip strength; Muscle-to-fat ratio; Physical activity; Sarcopenic obesity  \n[www.ejcma.org](www.ejcma.org) 367  \n\u003Cz10.1097/JCMA.0000000000001229>  \nChang et al. J Chin MedAssoc  \n1. INTRODUCTION  \nAging is a complex process characterized by impaired homeostasis, reduced physiological reserves, increased multimorbidity, and a decrease in physical and cognitive function, which, intertwined with heightened social vulnerability, lead to adverse health outcomes later in life for older adults.1 At the population level, these adverse health challenges significantly affect individuals, societies, and global communities and are worsened by increases in life expectancy and unhealthy life-years, especially in societies that are rapidly aging.2 By 2050, approximately 22% of the global population will be 60 years or older, up from 12% in 2015, which poses numerous challenges as health and social infrastructures worldwide struggle to adapt, particularly because the majority of this older population will reside in lowand middle-income countries with co","cbCaifoDplzOcj37","https://ap.wps.com/l/cbCaifoDplzOcj37","pdf",932383,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Keywords","[{\"question\":\"What was the purpose of this study?\",\"answer\":\"To examine the relationship between the muscle-to-fat ratio and 3-year decrease in handgrip strength in community-dwelling adults aged 50 years and older.\"},{\"question\":\"How was the muscle-to-fat ratio measured?\",\"answer\":\"Appendicular skeletal muscle mass was measured using bioimpedance analysis, then divided by total body fat to derive the muscle-to-fat ratio.\"},{\"question\":\"What factors were associated with a lower risk of rapid handgrip strength decline?\",\"answer\":\"A greater muscle-to-fat ratio, greater physical activity, and lower glycated hemoglobin (HbA1c) were associated with reduced risk of rapid decline.\"}]","High muscle-to-fat ratio predicts slow muscle strength decline in middle-aged and older adults - Longitudinal aging study of Taipei | PDF",1790664982]