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This descriptive cross-sectional study evaluates staging and radiologic imaging patterns of CRC at diagnosis in Ethiopian patients using consecutive cases from radiology and oncology. Among 132 patients (M:F=2.4:1; mean age 46 years), 84.5% presented at an advanced stage and 32% had distant metastasis. Imaging features and symptoms differed by tumor side, and young age related to advanced stage. 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High Magnitude Advanced Colorectal Cancer at Diagnosis in Ethiopian Patients: Imaging Pattern and Associated Factors . Ethiop J Health Sci. 2023;33(1):81. doi:[http://dx.doi.org/10.4314/ejhs.v33i1.1](http://dx.doi.org/10.4314/ejhs.v33i1.1)[ ](http://dx.doi.org/10.4314/ejhs.v33i1.1)1  \nReceived: August 25, 2022  \nAccepted: November 12, 2022  \nPublished: January 1, 2023  \nCopyright: © 2023 Assefa [G.K. et](G.K. et) al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Funding: This work was supported by Addis Ababa University, College of Health Sciences, Ethiopia  \nCompeting Interests: The authors declare that this manuscript was approved by all authors in its form and that no competing interest exists .  \nAffiliation and Correspondence: 1Department of radiology, School of Medicine, College of Health Sciences, Addis Ababa University  \n*[Email: kebedetesfaye@yahoo.com](Email: kebedetesfaye@yahoo.com)  \nABSTRACT  \nBACKGROUND: Colorectal cancer (CRC) is one of the most prevalent and incident cancers worldwide with an Increasing prevalence in a younger age in developing countries. The aim of the study was to determine the staging and imaging pattern of CRCat diagnosis.  \nMETHODS: This is a descriptive cross-sectional study including all consecutive cases of CRC found in the departments of radiology and oncology during the study period from March 2016-February 2017.  \nRESULTS: A total of 132 CRC cases were studied with M: F = 2.4:1, mean age of 46yrs and 67.4% \u003C/= 50yrs. Left-sided tumors were associated with rectal bleeding (p = 0.001) and bowel habit change (p =0.045) whereas right-side tumors were associated with weight loss ( p = 0.02) and abdominal pain ( p = 0.004). 84.5% of CRC presented at an advanced stage, and 32% had distant metastasis. Young age was associated with the advanced stage (P=0.006) whereas family history was associated with the lower stage (P=0.008). Distance metastasis was associated with Colonic lesions (P=0.003) and emergent presentation (P=0.008). Asymmetric wall thickening with luminal narrowing was significantly associated with left side tumor (95% vs 21.4%) whereas large mass with necrosis was significantly associated with right side tumor (50% vs 5%) (P= 0.004),  \nCONCLUSION: CRC is presented at a younger age and at an advanced stage. The majority of CRCs were left-sided and rectal. Increasing the index of suspicion for CRC in patients with rectal bleeding and, bowel habit change is recommended  \nKEYWORDS: Colorectal cancer, rectal cancer , stage, diagnosis INTRODUCTION  \nColon and rectal cancer (CRC) is one of the most prevalent and incident cancers worldwide, accounting for 1 in 10 of all cancer cases. Globally CRC is the second cause of cancer death and third in terms of incidence. It also causes more deaths in men than in women worldwide ( 1, 2) .  \nKnowledge of the location and extent of the primary tumor at initial diagnosis is critical for proper management of the disease asthe prognosis of CRC is directly related to the stage at presentation. In UK, approximately 70% of cases involve the colon, and the  \nremaining 30% involve the anus and rectum (3). Similarly, a report from Greece showed a proximal migration of tumors over time (4) .  \nThere are scanty reports from Ethiopia regarding CRC. One single report from Israel showed a high prevalence ofCRC ( 19% of all cancers) in Ethiopian Jewish . Few reports from the teaching hospitals in Ethiopia showed younger age and advanced s","cbCaim1YrQ4XnkAB","https://ap.wps.com/l/cbCaim1YrQ4XnkAB","pdf",248888,"English","# Abstract\n# Introduction\n# Material and Methods\n## Study area\n## Study design and period\n## Study population\n## Sample size and sampling","[{\"question\":\"What was the study aim regarding colorectal cancer at diagnosis?\",\"answer\":\"To determine CRC staging and imaging patterns at diagnosis in Ethiopian patients.\"},{\"question\":\"How many CRC cases were included and what proportion presented with advanced stage?\",\"answer\":\"A total of 132 CRC cases were studied, and 84.5% presented at an advanced stage.\"},{\"question\":\"Which symptoms were associated with tumors on the left versus the right side?\",\"answer\":\"Left-sided tumors were associated with rectal bleeding and bowel habit change, while right-side tumors were associated with weight loss and abdominal pain.\"}]","High Magnitude Advanced Colorectal Cancer at Diagnosis in Ethiopian Patients - Imaging Pattern and Associated Factors | PDF",1790269962,25]