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Six electronic databases were searched and eligible studies were screened using predefined inclusion and exclusion criteria. Pooled hazard ratios and odds ratios from extracted hazard ratios, 95% confidence intervals, TNM stage, distant metastasis, lymph node status, and tumor size were analyzed, with sensitivity testing and Begg’s test for publication bias. High linc01116 expression predicts worse overall, progression-free, and disease-free survival and correlates with advanced TNM stage and poor histological grade.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/high-linc01116-expression-may-contribute-to-a-poor-prognosis-in-various-cancers-based-on-systematic-reviews-and-meta-analyses/331658/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/high-linc01116-expression-may-contribute-to-a-poor-prognosis-in-various-cancers-based-on-systematic-reviews-and-meta-analyses/331658.png","ImageObject",300,407,{"name":92,"@type":93},"Theodora","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the purpose of the meta-analysis regarding linc01116?","Question",{"text":112,"@type":113},"To examine the correlation between linc01116 expression and cancer prognosis across eligible studies, using pooled hazard ratios and odds ratios.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which outcomes were associated with high linc01116 expression?",{"text":117,"@type":113},"High linc01116 expression correlated with poor overall survival, progression-free survival, and disease-free survival, and with advanced TNM stage and poor histological grade.",{"name":119,"@type":110,"acceptedAnswer":120},"Was publication bias detected in the included studies?",{"text":121,"@type":113},"No. Begg’s test indicated no significant publication bias among the included studies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331658,1790158294,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36,"preview_page_count":4},687197207919,"https://ap-avatar.wpscdn.com/avatar/a000253d6f5f7c60be?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779446848396160552","Fan etal. BMC Cancer (2024) 24:1566  \n[https://doi.org/10.1186/s12885-024-13293-4](https://doi.org/10.1186/s12885-024-13293-4)  \nBMC Cancer  \n SYSTEMATIC REVIEW Open Access  \nHigh linc01116 expression may contribute   to a poor prognosis in various cancers based on systematic reviews and meta-analyses  \nSi-Tong Fan 1†, Dan Li2†, Qun-Xian Zhang3†, Li-Qiang Xu3, Tao Zeng3, Qiang Liu3, Qiang Guo3*, Chen-Yi Lin3* and Wei-Min Luo4*  \nAbstract  \nBackground Long non-coding RNA 01116 (linc01116) has been shown to be dysregulated in many tumors, and is closely related to the prognosis. This meta-analysis aimed to examine the correlation between linc01116 expression and cancer prognosis.  \nMethods Six electronic databases were searched, and eligible studies were screened based on the inclusion and exclusion criteria. Data including hazard ratios (HRs) and 95% confidence intervals (CIs), TNM stage, distant metastasis (DM) status, lymph node metastasis (LNM) status, and tumor size were extracted from the included studies. HRs and odds ratios (ORs) with their corresponding 95% CIs were separately pooled to assess the relationship between linc01116 expression and cancer prognosis. Sensitivity analysis and Begg’s test were performed to assess publication or other biases.  \nResults A total of 12 studies involving 809 patients were included in this meta-analysis. Analysis of pooled HRs with 95% CIs showed that high linc01116 expression was significantly correlated with poor overall survival (OS)(HR = 2 . 096; 95% CI: 1.555–2. 638), progression-free survival (PFS) (HR, 1. 9314; 95% CI: 1.020–3. 657), disease-free survival (DFS) (HR = 2 . 067; 95% CI: 1.0889–3. 9238), an advanced TNM stage (OR, 1. 803; 95% CI: 1.270–2. 562), and a poor histological grade (OR, 1. 968; 95% CI: 1.288–3. 007) . However, no significant correlation was observed between linc01116 expression and LNM (OR, 1. 198; 95% CI: 0 .831–1. 728), DM (OR, 1. 114; 95% CI: 0 .757–1. 638), tumor size (OR, 1. 336; 95% CI: 0 .989–1. 804), depth of invasion (OR, 1. 375; 95% CI: 0 .756–2. 501), age (OR, 0 . 976; 95% CI: 0 .742–1. 283), or sex (OR, 0 . 810; 95% CI: 0 .599–1. 094) . Sensitivity analysis indicated that the overall results of OS analysis were reliable and robust. In addition, Begg’s test showed that none of the included studies had significant publication bias. Conclusion linc01116 is upregulated in most cancers, and this upregulation is associated with a poor prognosis. Therefore, linc01116 serves as a promising therapeutic target and prognostic biomarker for cancer.  \nKeywords LncRNA, Linc01116, Cancer, Prognosis, Meta-analysis  \n†Si-Tong Fan, Dan Li and Qun-Xian Zhang are co-first author.  \n*Correspondence:  \nQiang Guo [guoqianglidan@163.com](guoqianglidan@163.com)[ ](guoqianglidan@163.com)Chen-Yi Lin [13986886667@163.com](13986886667@163.com)[ ](13986886667@163.com)Wei-Min Luo [weiminluo120@163.com](weiminluo120@163.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [h","cbCaig5jijQSLDv6","https://ap.wps.com/l/cbCaig5jijQSLDv6","pdf",2913413,16,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What was the purpose of the meta-analysis regarding linc01116?\",\"answer\":\"To examine the correlation between linc01116 expression and cancer prognosis across eligible studies, using pooled hazard ratios and odds ratios.\"},{\"question\":\"Which outcomes were associated with high linc01116 expression?\",\"answer\":\"High linc01116 expression correlated with poor overall survival, progression-free survival, and disease-free survival, and with advanced TNM stage and poor histological grade.\"},{\"question\":\"Was publication bias detected in the included studies?\",\"answer\":\"No. Begg’s test indicated no significant publication bias among the included studies.\"}]","High linc01116 expression may contribute to a poor prognosis in various cancers based on systematic reviews and meta-analyses | PDF",1789994479]