[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-340532-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-340532-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","high-intensity-focused-ultrasound-strategies-for-treating-prostate-cancer","High-intensity focused ultrasound strategies for treating prostate cancer","","Prostate cancer (PCa) remains a major global health challenge, driving demand for effective yet tissue-sparing treatment options for localized disease. This invited narrative review summarizes the evolution of high-intensity focused ultrasound (HIFU) within focal therapy, highlighting newer transrectal and transurethral systems with improved treatment distances, MRI fusion, real-time monitoring, and precise ablation. It evaluates whole-gland, hemigland, and focal ablation strategies and concludes that nonwhole-gland HIFU can offer comparable cancer control with better short-term functional outcomes and fewer complications. Combining HIFU with TURP may improve urinary function and reduce catheterization time, while focal and hemigland ablation preserve continence and potency.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/high-intensity-focused-ultrasound-strategies-for-treating-prostate-cancer/340532/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/high-intensity-focused-ultrasound-strategies-for-treating-prostate-cancer/340532.png","ImageObject",300,407,{"name":42,"@type":43},"Evangeline","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What role does focal therapy (FT) play in early localized prostate cancer?","Question",{"text":63,"@type":64},"FT targets small tumors confined to a specific prostate region. It aims to control cancer while minimizing damage to surrounding benign tissue.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do modern HIFU systems improve treatment planning and delivery?",{"text":68,"@type":64},"Advances include longer treatment distances, MRI fusion for targeting, real-time monitoring (such as temperature monitoring), and more precise ablation to enhance effectiveness and outcomes.",{"name":70,"@type":61,"acceptedAnswer":71},"What does the review conclude when comparing nonwhole-gland HIFU with whole-gland ablation?",{"text":72,"@type":64},"Nonwhole-gland HIFU is concluded to provide similar cancer control with better short-term functional outcomes and fewer complications than whole-gland ablation.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},340532,1790534267,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":97,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},13056703019662,"https://ap-avatar.wpscdn.com/avatar/be000253a8e92610077?_k=1778726343310543188","Prostate Cancer  \nOpen Access  \nINVITED REVIEW  \nHigh-intensity focused ultrasound strategies for treating prostate cancer  \nXiaobo Wu1, Yupeng Wu2, Chi-Fai Ng1, Chi-Hang Yee1, Peter Ka-Fung Chiu1  \nProstate cancer (PCa) is a significant health concern globally, necessitating effective treatment options. Typical treatment methods for early stage, particularly localized PCa, encompass radical procedures, such as radical prostatectomy (RP) and radiotherapy (RT), and nonradical focal therapy (FT) . FT is a focused approach mainly used for treating small lesions limited to a specific zone of the prostate. Its objective is to achieve cancer control when minimizing damage to benign tissue. High-intensity focused ultrasound (HIFU) is one of the most used modalities in FT for the management of PCa. The progress in HIFU technology showcases continuous advancements, offering clinicians a variety of strategies to cater to diverse patient requirements. The advancements include the development of transrectal and transurethral HIFU machines that offer enhanced treatment distances, magnetic resonance imaging (MRI) fusion capabilities, real-time monitoring, and precise ablation. These improvements contribute to increased treatment effectiveness and better outcomes for patients. This narrative review aims to summarize the use of HIFU technology and its evolution, offering diverse options to clinicians, and explores the safety, effectiveness, and quality of different HIFU strategies, such as whole-gland ablation, hemigland ablation, and focal ablation. We conclude that nonwhole-gland HIFU offers similar cancer control with better short-term functional outcomes and fewer complications compared to whole-gland ablation. Combining HIFU with transurethral resection of the prostate (TURP) improves urinary function and reduces catheterization time. Focal ablation and hemigland ablation show promise in achieving cancer control when preserving continence and potency.  \nAsian Journal of Andrology (2024) 26 , 595–599; doi: 10.4103/aja20245; published online: 26 April 2024 Keywords: ablation; focal therapy; high-intensity focused ultrasound; prostate cancer; strategy  \nINTRODUCTION  \nProstate cancer (PCa) is a prevalent malignancy affecting men worldwide, particularly in aging populations.1–3 It is estimated that PCa is the second most diagnosed cancer and the fifth leading cause of cancer-related deaths among men globally, highlighting the significance of effective treatment options for this disease.3,4 Standard treatment approaches for early stage, mainly localized PCa, include radical treatments, such as radical prostatectomy (RP),5,6 radiotherapy (RT),6,7 and nonradical focal therapy (FT).8,9 FT is a targeted approach primarily employed for small tumors confined to a specific area of the prostate, aiming to achieve cancer control when minimizing harm to benign tissue.10  \nSignificant advancements have been made in high-intensity focused ultrasound (HIFU) machines. Sonacare Inc. (Charlotte, NC, USA) has developed the Sonablate® HIFU, a transrectal device with a treatment distance of approximately 3.5 cm. Sonacare Inc. also offers the Sonafuse™-MIM Symphony™, an optional choice that incorporates magnetic resonance imaging (MRI) fusion for enhanced precision.  \nEDAP TMS (Vaulx-en-Velin, France) provides the Ablatherm® Fusion Robotic HIFU, along with the recently introduced Focal One® . The Focal One® offers a treatment distance of 4.0 cm, showcasing advanced capabilities for precise and targeted treatment.  \nInsightec (Tirat Carmel, Israel) has developed the ExAblate™ real-time MRI-guided HIFU machine, which stands out for its  \nreal-time temperature monitoring and immediate confirmation of treatment outcomes. The clinical team can optimize treatment results by monitoring the procedure in real time using thermometry data. Additionally, a contrast image is used atthe end of treatment to confirm successful delivery.  \nThere is also another transurethral rea","cbCaii3dK30riwjT","https://ap.wps.com/l/cbCaii3dK30riwjT","pdf",222963,"English","# INTRODUCTION\n## Evolution of HIFU machines\n## Clinical outcomes and strategy comparisons\n## Mechanism of action of HIFU","[{\"question\":\"What role does focal therapy (FT) play in early localized prostate cancer?\",\"answer\":\"FT targets small tumors confined to a specific prostate region. It aims to control cancer while minimizing damage to surrounding benign tissue.\"},{\"question\":\"How do modern HIFU systems improve treatment planning and delivery?\",\"answer\":\"Advances include longer treatment distances, MRI fusion for targeting, real-time monitoring (such as temperature monitoring), and more precise ablation to enhance effectiveness and outcomes.\"},{\"question\":\"What does the review conclude when comparing nonwhole-gland HIFU with whole-gland ablation?\",\"answer\":\"Nonwhole-gland HIFU is concluded to provide similar cancer control with better short-term functional outcomes and fewer complications than whole-gland ablation.\"}]","High-intensity focused ultrasound strategies for treating prostate cancer | PDF",1790037149,13]