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The review details thermal coagulation, acoustic cavitation, and immunomodulation, summarizing evidence for actinic keratosis and basal cell carcinoma, including reported 70–97% clearance rates and favorable cosmetic outcomes, while noting ongoing work on long-term oncologic endpoints and standardized protocols.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/high-intensity-focused-ultrasound-in-dermatology-a-review-with-emphasis-on-skin-cancer-management-and-prevention/362070/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/high-intensity-focused-ultrasound-in-dermatology-a-review-with-emphasis-on-skin-cancer-management-and-prevention/362070.png","ImageObject",300,407,{"name":42,"@type":43},"Asher","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is HIFU and how does it work in dermatology?","Question",{"text":63,"@type":64},"HIFU uses concentrated sound waves to produce localized thermal coagulation and acoustic cavitation, with additional immunomodulatory effects. Dermatological platforms at ~20 MHz target the epidermis and superficial dermis for precise lesion ablation.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which skin conditions does the review focus on for HIFU treatment?",{"text":68,"@type":64},"The review emphasizes management of actinic keratosis and basal cell carcinoma (BCC). It describes current evidence and early clinical outcomes for these conditions.",{"name":70,"@type":61,"acceptedAnswer":71},"How does HIFU compare with established therapies like surgery, photodynamic therapy, or cryotherapy?",{"text":72,"@type":64},"Compared with conventional options, HIFU is described as offering reduced procedural pain, faster healing, and the ability to treat multiple lesions in a single session. 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Cancers 2025, 17, 3518. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/cancers17213518](10.3390/cancers17213518)  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Old Town Clinic, 50-136 Wroclaw, Poland  \n2 Dermatology Clinic, National Institute of Medicine of the Ministry of Interior and Administration, 02-507 Warsaw, Poland  \n3 Department of Clinical Pharmacology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland; [natalia.sauer@umw.edu.pl](natalia.sauer@umw.edu.pl)  \n* [Correspondence: barwoz91@gmail.com](Correspondence: barwoz91@gmail.com) (B.W.); [piotr.sobolewski@pimmswia.gov.pl](piotr.sobolewski@pimmswia.gov.pl) (P.S.)  \nSimple Summary  \nSkin cancers are becoming increasingly common, and many patients need treatments that are both effective and minimally invasive. High-intensity focused ultrasound (HIFU) is a new technique that uses concentrated sound waves to precisely destroy abnormal skin cells without cutting the skin. This review explains how HIFU works and summarizes the current evidence for its use in skin conditions such as actinic keratosis and basal cell carcinoma. Early studies suggest that HIFU can remove precancerous and cancerous lesions with acceptable safety and promising clinical results. Because it can target only the affected area while leaving healthy skin intact, HIFU may become an important alternative or addition to surgery and other established methods. The findings presented here may help guide future research and clinical practice in non-invasive skin cancer management.  \nAbstract  \nHigh-intensity focused ultrasound (HIFU) has recently emerged as a novel non-invasive treatment modality in dermatology, offering precise ablation of cutaneous lesions with minimal damage to surrounding tissue. Originally developed for deep-seated tumors, dermatological HIFU platforms operating at ~20 MHz enable submillimeter-scale treatment of thermal or mechanical injuries localized to the epidermis and superficial dermis, making them suitable for managing benign, premalignant, and malignant skin conditions. This review outlines the mechanistic basis of HIFU—including thermal coagulation, acoustic cavitation, and immunomodulatory effects—and presents the current evidence for its efficacy in treating actinic keratoses and basal cell carcinomas (BCCs), where early studies report clearance rates of 70–97% and excellent cosmetic outcomes. Compared to conventional therapies such as surgery, photodynamic therapy, or cryotherapy, HIFU offers reduced procedural pain, faster healing, and the ability to treat multiple lesions in a single session. Its role in field cancerization and potential utility in prophylaxis for high-risk skin areas are also explored. While promising, long-term oncologic outcomes and standardized treatment protocols remain under investigation. HIFU represents a significant advancement in non-invasive skin cancer management, aligning oncologic efficacy with patient-centered care.  \nKeywords: high-intensity focused ultrasound; skin cancer; basal cell carcinoma; actinic keratosis; non-invasive therapy; field cancerization; derma","cbCaisWzGVMr74pe","https://ap.wps.com/l/cbCaisWzGVMr74pe","pdf",3225050,33,"English","# Introduction\n## Epidemiology of non-melanoma skin cancers\n## Molecular pathogenesis of BCC and SCC\n## Limitations of surgical excision","[{\"question\":\"What is HIFU and how does it work in dermatology?\",\"answer\":\"HIFU uses concentrated sound waves to produce localized thermal coagulation and acoustic cavitation, with additional immunomodulatory effects. Dermatological platforms at ~20 MHz target the epidermis and superficial dermis for precise lesion ablation.\"},{\"question\":\"Which skin conditions does the review focus on for HIFU treatment?\",\"answer\":\"The review emphasizes management of actinic keratosis and basal cell carcinoma (BCC). It describes current evidence and early clinical outcomes for these conditions.\"},{\"question\":\"How does HIFU compare with established therapies like surgery, photodynamic therapy, or cryotherapy?\",\"answer\":\"Compared with conventional options, HIFU is described as offering reduced procedural pain, faster healing, and the ability to treat multiple lesions in a single session. The review also highlights its potential role as an alternative or addition to surgery.\"}]","High-Intensity Focused Ultrasound in Dermatology - A Review with Emphasis on Skin Cancer Management and Prevention | PDF",1790146397,83]