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The case involves a 47-year-old woman presenting with irregular vaginal bleeding and diagnostic findings suggesting HPV 16 infection with atypical SCC cells. After comprehensive staging with imaging and pathology, the patient underwent laparoscopic radical hysterectomy and related procedures, followed by postoperative chemotherapy leading to complete remission. Genetic testing identified BRCA2 mutations, and PARP inhibitors were used for maintenance therapy. ",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/high-grade-serous-papillary-ovarian-carcinoma-combined-with-nonkeratinizing-squamous-cell-carcinoma-of-the-cervix-a-case-report/333237/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/high-grade-serous-papillary-ovarian-carcinoma-combined-with-nonkeratinizing-squamous-cell-carcinoma-of-the-cervix-a-case-report/333237.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What makes the reported condition clinically rare?","Question",{"text":112,"@type":113},"The report highlights synchronously combined malignancies arising from the cervix and ovary, which are described as extremely rare compared with other multiple primary malignant neoplasm patterns.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What diagnostic findings supported the suspicion of cervical and ovarian cancers?",{"text":117,"@type":113},"ThinPrep cytology suggested atypical SCC cells and HPV 16, cervical biopsy indicated grade-III cervical intraepithelial neoplasia, and colposcopy plus imaging (MRI and PET-CT) showed cervical lesions and suspected metastatic masses.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment and follow-up strategy was used after surgery?",{"text":121,"@type":113},"The patient received postoperative chemotherapy with a Taxol and Carboplatin regimen to achieve complete remission, followed by genetic testing for BRCA2 mutations and maintenance therapy with PARP inhibitors.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333237,1790649285,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":46,"preview_page_count":4},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","TYPE Case Report  \nPUBLISHED 07 March 2024  \nDOI 10.3389/fonc.2024.1298109  \nOPEN ACCESS  \nEDITED BY  \nSophia George,  \nUniversity of Miami, United States  \nREVIEWED BY  \nFederica Perelli,  \nAzienda USL Toscana Centro, Italy Dilyara Kaidarova,  \nKazakh Institute of Oncology and Radiology, Kazakhstan  \n*CORRESPONDENCE Lianli He  \n [1744122878@qq.com](1744122878@qq.com)  \n†These authors share first authorship  \nRECEIVED 21 September 2023  \nACCEPTED 29 January 2024  \nPUBLISHED 07 March 2024  \nCITATION  \nWu M, Zhang W, He L, Zhu Y, Jiang X, Zhang L, Yuan X and Li T (2024) High-grade serous papillary ovarian carcinoma combined with nonkeratinizing squamous cell carcinoma of the cervix: a case report.  \nFront. Oncol. 14:1298109 .  \ndoi: 10.3389/fonc.2024.1298109  \nCOPYRIGHT  \n© 2024 Wu, Zhang, He, Zhu, Jiang, Zhang, Yuan and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nHigh-grade serous papillary ovarian carcinoma combined with nonkeratinizing squamous cell carcinoma of the cervix: a case report  \nMaoyuan Wu 1†, Wenwen Zhang 1†, Lianli He 2*, Ye Zhu 2, Xiaoling Jiang 2, Lixia Zhang 2, Xiwei Yuan 3 and Tingchao Li 4  \n1 Department of Gynecology and Obstetrics, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, China, 2 Department of Gynecology, The Third Affiliated Hospital of Zunyi Medical University (The First People ’s Hospital of Zunyi), Zunyi, Guizhou, China, 3 Department of Imaging, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, China, 4 Department of Pathology, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, China  \nMultiple primary malignant neoplasms are a rare gynecologic malignancy; particularly, cases originating from the heterologous organs, such as the ovary and cervix. Here, we report a case of two primary malignant neoplasms in a patient who had undergone laparoscopic radical hysterectomy + bilateral salpingo-oophorectomy + pelvic lymph node dissection + para-aortic lymphadenectomy + appendectomy + omentectomy + metastasectomy under general anesthesia. The patient experienced complete remission after six courses of postoperative chemotherapy with a standard Taxol and Carboplatin regimen. Genetic testing was performed to detect BRCA2 mutations, and poly (ADP-ribose) polymerase (PARP) inhibitors were used for maintenance therapy.  \nKEYWORDS  \ncase report, multiple primary malignant neoplasms, cervical cancer, ovarian cancer, high-grade serous papillary carcinoma  \n1 Introduction  \nMultiple primary malignant neoplasms (MPMN) were first described by Billroth et al. in 1889 (1) . Many clinical cases of MPMN have been reported since. Most patients have metachronous MPMN as MPMN occurrences are rarely synchronous. MPMNs originating from the female reproductive system account for 1–2% of the cases of gynecologic malignant neoplasms. Among these cases, the most prevalent ones, accounting for approximately 50–70% of cases, have synchronous ovarian and endometrial cancers arising from homologous tissues (2, 3) . However, cases of malignant neoplasms synchronously arising from the cervix and ovary are extremely rare.  \nFrontiers in Oncology 01 [frontiersin.org](frontiersin.org)  \nHere, we report a case of high-grade serous papillary carcinoma (HGSOC) of the ovary combined with nonkeratinizing squamous cell carcinoma (SCC) of the cervix with multiple metastases from the HGSOC.  \n2 Case report  \nA 47-year-old woman was admitted to the hospital because of irreg","cbCaijWcm5wHeM4r","https://ap.wps.com/l/cbCaijWcm5wHeM4r","pdf",6911327,"English","# Introduction\n# Case report","[{\"question\":\"What makes the reported condition clinically rare?\",\"answer\":\"The report highlights synchronously combined malignancies arising from the cervix and ovary, which are described as extremely rare compared with other multiple primary malignant neoplasm patterns.\"},{\"question\":\"What diagnostic findings supported the suspicion of cervical and ovarian cancers?\",\"answer\":\"ThinPrep cytology suggested atypical SCC cells and HPV 16, cervical biopsy indicated grade-III cervical intraepithelial neoplasia, and colposcopy plus imaging (MRI and PET-CT) showed cervical lesions and suspected metastatic masses.\"},{\"question\":\"What treatment and follow-up strategy was used after surgery?\",\"answer\":\"The patient received postoperative chemotherapy with a Taxol and Carboplatin regimen to achieve complete remission, followed by genetic testing for BRCA2 mutations and maintenance therapy with PARP inhibitors.\"}]","High-grade serous papillary ovarian carcinoma combined with nonkeratinizing squamous cell carcinoma of the cervix - a case report | PDF",1790001603]